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Membranous lupus nephritis

MedGen UID:
884707
Concept ID:
C4054543
Disease or Syndrome
Synonyms: Class V lupus nephritis; Membranous Lupus Nephritis
 
HPO: HP:0033730

Definition

A lupus nephritis subclass with global or segmental subepithelial immune deposits or their morphological sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. May occur in combination with class III or IV, in which case both classes are diagnosed. May show advanced sclerosis [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMembranous lupus nephritis

Professional guidelines

PubMed

Mok CC
Nat Rev Rheumatol 2016 Apr;12(4):221-34. Epub 2016 Jan 5 doi: 10.1038/nrrheum.2015.174. PMID: 26729459
Alshayeb H, Wall BM, Gosmanova EO
Am J Med Sci 2012 Jan;343(1):86-90. doi: 10.1097/MAJ.0b013e31821996ca. PMID: 21685786
Beck LH Jr, Salant DJ
J Am Soc Nephrol 2009 Apr;20(4):690-1. Epub 2009 Mar 11 doi: 10.1681/ASN.2009020216. PMID: 19279123

Recent clinical studies

Etiology

Banos A, Bertsias G
Curr Rheumatol Rep 2023 Oct;25(10):183-191. Epub 2023 Jul 15 doi: 10.1007/s11926-023-01109-6. PMID: 37452914Free PMC Article
Tang KT, Tseng CH, Hsieh TY, Chen DY
Int J Rheum Dis 2018 Jun;21(6):1163-1172. doi: 10.1111/1756-185X.13321. PMID: 29879319
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Austin HA, Illei GG
Lupus 2005;14(1):65-71. doi: 10.1191/0961203305lu2062oa. PMID: 15732291
Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M; International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis
Kidney Int 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x. PMID: 14717922

Diagnosis

Almaani S, Parikh SV
Adv Chronic Kidney Dis 2019 Sep;26(5):393-403. doi: 10.1053/j.ackd.2019.08.009. PMID: 31733724
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Austin HA, Illei GG
Lupus 2005;14(1):65-71. doi: 10.1191/0961203305lu2062oa. PMID: 15732291
Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M; International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis
Kidney Int 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x. PMID: 14717922

Therapy

Zheng X, Ouyang X, Cheng C, Rong L, Chen L, Mo Y, Jiang X
Pediatr Res 2023 Dec;94(6):2040-2046. Epub 2023 Jul 24 doi: 10.1038/s41390-023-02747-3. PMID: 37488301
Banos A, Bertsias G
Curr Rheumatol Rep 2023 Oct;25(10):183-191. Epub 2023 Jul 15 doi: 10.1007/s11926-023-01109-6. PMID: 37452914Free PMC Article
Tang KT, Tseng CH, Hsieh TY, Chen DY
Int J Rheum Dis 2018 Jun;21(6):1163-1172. doi: 10.1111/1756-185X.13321. PMID: 29879319
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Austin HA, Illei GG
Lupus 2005;14(1):65-71. doi: 10.1191/0961203305lu2062oa. PMID: 15732291

Prognosis

Banos A, Bertsias G
Curr Rheumatol Rep 2023 Oct;25(10):183-191. Epub 2023 Jul 15 doi: 10.1007/s11926-023-01109-6. PMID: 37452914Free PMC Article
Almaani S, Parikh SV
Adv Chronic Kidney Dis 2019 Sep;26(5):393-403. doi: 10.1053/j.ackd.2019.08.009. PMID: 31733724
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Austin HA, Illei GG
Lupus 2005;14(1):65-71. doi: 10.1191/0961203305lu2062oa. PMID: 15732291

Clinical prediction guides

Banos A, Bertsias G
Curr Rheumatol Rep 2023 Oct;25(10):183-191. Epub 2023 Jul 15 doi: 10.1007/s11926-023-01109-6. PMID: 37452914Free PMC Article
Ye J, Croom N, Troxell ML, Kambham N, Zuckerman JE, Andeen N, Dall'Era M, Hsu R, Walavalkar V, Laszik ZG, Urisman A
Kidney360 2023 Jul 1;4(7):935-942. Epub 2023 May 31 doi: 10.34067/KID.0000000000000161. PMID: 37257088Free PMC Article
Pereira M, Muscal E, Eldin K, Hicks MJ, Sagcal-Gironella ACP, DeGuzman M, Wenderfer SE
Pediatr Nephrol 2017 Dec;32(12):2283-2291. Epub 2017 Jul 17 doi: 10.1007/s00467-017-3743-z. PMID: 28717937
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Rothfield NF
Contrib Nephrol 1977;7:128-42. doi: 10.1159/000400120. PMID: 330103

Recent systematic reviews

Tang KT, Tseng CH, Hsieh TY, Chen DY
Int J Rheum Dis 2018 Jun;21(6):1163-1172. doi: 10.1111/1756-185X.13321. PMID: 29879319
Swan JT, Riche DM, Riche KD, Majithia V
J Investig Med 2011 Feb;59(2):246-58. doi: 10.2310/JIM.0b013e318204c965. PMID: 21328792

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