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Bone Marrow and Extramedullary Involvement

MedGen UID:: 885081
•Concept ID:: C4055373
•: Finding

Definition

A finding indicating the involvement of the bone marrow and other anatomic sites, which may include the peripheral blood, lymph nodes, and/or extranodal sites, by a hematopoietic neoplasm. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone Marrow and Extramedullary Involvement

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Hematopoietic system finding
      - Bone Marrow and Extramedullary Involvement
        Bone Marrow and Blood Involvement
        Extensive Bone Marrow and Blood Involvement
        Bone Marrow Involvement
        Extramedullary Involvement
        Lymphomatous nodal involvement
        Axillary Lymph Node Involvement
        Matted Lymph Nodes
        Peripheral Blood Involvement

Professional guidelines

PubMed

Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse.

Wan X, Yang X, Yang F, Wang T, Ding L, Song L, Miao Y, Wang X, Ma Y, Luo C, Tang J, Gu L, Chen J, Tang Y, Lu J, Li B
Cancer Res Treat 2022 Jul;54(3):917-925. Epub 2021 Sep 17 doi: 10.4143/crt.2021.399. PMID: 34583462 Free PMC Article

See all (1)

Recent clinical studies

Etiology

Imaging Osteomyelitis: An Update.

Aydingoz U
Rofo 2023 Apr;195(4):297-308. Epub 2023 Feb 1 doi: 10.1055/a-1949-7641. PMID: 36724804

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

Extramedullary disease in multiple myeloma: a systematic literature review.

Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675 Free PMC Article

Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.

Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Solitary Plasmacytoma: a Review of Diagnosis and Management.

Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667

See all (188)

Diagnosis

Imaging Osteomyelitis: An Update.

Aydingoz U
Rofo 2023 Apr;195(4):297-308. Epub 2023 Feb 1 doi: 10.1055/a-1949-7641. PMID: 36724804

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

Extramedullary disease in multiple myeloma: a systematic literature review.

Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.

Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Solitary Plasmacytoma: a Review of Diagnosis and Management.

Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667

See all (386)

Therapy

Blinatumomab Conundrum in Low-Risk Relapsed B-Cell ALL.

Maese LD, Pulsipher MA
J Clin Oncol 2023 Sep 1;41(25):4087-4092. Epub 2023 Jun 13 doi: 10.1200/JCO.23.00594. PMID: 37311171

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

Extramedullary Disease in Multiple Myeloma.

Jagosky MH, Usmani SZ
Curr Hematol Malig Rep 2020 Apr;15(2):62-71. doi: 10.1007/s11899-020-00568-3. PMID: 32198576

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.

Park JH, Rivière I, Gonen M, Wang X, Sénéchal B, Curran KJ, Sauter C, Wang Y, Santomasso B, Mead E, Roshal M, Maslak P, Davila M, Brentjens RJ, Sadelain M
N Engl J Med 2018 Feb 1;378(5):449-459. doi: 10.1056/NEJMoa1709919. PMID: 29385376 Free PMC Article

Extramedullary Waldenström macroglobulinemia.

Banwait R, Aljawai Y, Cappuccio J, McDiarmid S, Morgan EA, Leblebjian H, Roccaro AM, Laubach J, Castillo JJ, Paba-Prada C, Treon S, Redd R, Weller E, Ghobrial IM
Am J Hematol 2015 Feb;90(2):100-4. Epub 2014 Nov 19 doi: 10.1002/ajh.23880. PMID: 25349134

See all (154)

Prognosis

Myeloid sarcoma: more and less than a distinct entity.

Loscocco GG, Vannucchi AM
Ann Hematol 2023 Aug;102(8):1973-1984. Epub 2023 Jun 7 doi: 10.1007/s00277-023-05288-1. PMID: 37286874 Free PMC Article

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

Extramedullary disease in multiple myeloma: a systematic literature review.

Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.

Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Solitary Plasmacytoma: a Review of Diagnosis and Management.

Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667

See all (268)

Clinical prediction guides

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma.

Vlachová M, Gregorová J, Vychytilová-Faltejsková P, Gabło NA, Radová L, Pospíšilová L, Almáši M, Štork M, Knechtová Z, Minařík J, Popková T, Jelínek T, Hájek R, Pour L, Říhová L, Ševčíková S
Int J Mol Sci 2022 Nov 25;23(23) doi: 10.3390/ijms232314765. PMID: 36499093 Free PMC Article

Myeloid/lymphoid neoplasms with FLT3 rearrangement.

Tang G, Tam W, Short NJ, Bose P, Wu D, Hurwitz SN, Bagg A, Rogers HJ, Hsi ED, Quesada AE, Wang W, Miranda RN, Bueso-Ramos CE, Medeiros LJ, Nardi V, Hasserjian RP, Arber DA, Orazi A, Foucar K, Wang SA
Mod Pathol 2021 Sep;34(9):1673-1685. Epub 2021 May 14 doi: 10.1038/s41379-021-00817-7. PMID: 33990705

Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.

Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.

See all (120)

Recent systematic reviews

Systematic review and meta-analysis evaluating clinical outcomes in adult acute myeloid leukemia patients with central nervous system involvement.

Goulart H, Sastow D, Moshier E, Martin L, Mascarenhas J, Tremblay D
Leuk Res 2024 Feb;137:107452. Epub 2024 Feb 6 doi: 10.1016/j.leukres.2024.107452. PMID: 38335816

Extramedullary disease in multiple myeloma: a systematic literature review.

Diffuse parenchymal pulmonary amyloidosis associated with multiple myeloma: a case report and systematic review of the literature.

Liu Y, Jin Z, Zhang H, Zhang Y, Shi M, Meng F, Sun Q, Cai H
BMC Cancer 2018 Aug 8;18(1):802. doi: 10.1186/s12885-018-4565-5. PMID: 30089469 Free PMC Article

¹⁸F-FDG PET/CT: a review of diagnostic and prognostic features in multiple myeloma and related disorders.

Dammacco F, Rubini G, Ferrari C, Vacca A, Racanelli V
Clin Exp Med 2015 Feb;15(1):1-18. Epub 2014 Sep 14 doi: 10.1007/s10238-014-0308-3. PMID: 25218739

Extramedullary hemopoiesis.

Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS
Semin Ultrasound CT MR 2014 Jun;35(3):255-62. Epub 2013 Dec 19 doi: 10.1053/j.sult.2013.12.001. PMID: 24929265

See all (5)

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Bone Marrow and Extramedullary Involvement

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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