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Acute Lymphoblastic Leukemia by Gene Expression Profile

MedGen UID:
890737
Concept ID:
C4055498
Neoplastic Process
Synonyms: Acute Lymphoblastic Leukemia by Gene Expression Signature; Acute Lymphoblastic Leukemia Gene Expression Subtype; ALL by Gene Expression Profile; ALL by Gene Expression Signature; ALL Gene Expression Cluster Subtype; ALL Gene Expression Subtype

Definition

Gene expression-based patient cluster groups in acute lymphoblastic leukemia. [from NCI]

Professional guidelines

PubMed

Ryan SL, Peden JF, Kingsbury Z, Schwab CJ, James T, Polonen P, Mijuskovic M, Becq J, Yim R, Cranston RE, Hedges DJ, Roberts KG, Mullighan CG, Vora A, Russell LJ, Bain R, Moorman AV, Bentley DR, Harrison CJ, Ross MT
Leukemia 2023 Mar;37(3):518-528. Epub 2023 Jan 19 doi: 10.1038/s41375-022-01806-8. PMID: 36658389Free PMC Article
Zhang H, Qureshi MA, Wahid M, Charifa A, Ehsan A, Ip A, De Dios I, Ma W, Sharma I, McCloskey J, Donato M, Siegel D, Gutierrez M, Pecora A, Goy A, Albitar M
Am J Pathol 2023 Jan;193(1):51-59. Epub 2022 Oct 13 doi: 10.1016/j.ajpath.2022.09.006. PMID: 36243045
Liu M, Liao H, Chen Y, Lin Z, Liu Y, Zhang X, Chan HC, Sun H
Leuk Res 2019 Nov;86:106225. Epub 2019 Sep 13 doi: 10.1016/j.leukres.2019.106225. PMID: 31541940

Recent clinical studies

Etiology

Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Tasian SK, Loh ML, Hunger SP
Blood 2017 Nov 9;130(19):2064-2072. Epub 2017 Oct 2 doi: 10.1182/blood-2017-06-743252. PMID: 28972016Free PMC Article
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG
N Engl J Med 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088. PMID: 25207766Free PMC Article

Diagnosis

Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183. Epub 2016 May 13 doi: 10.1016/j.ebiom.2016.04.038. PMID: 27428428Free PMC Article
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG
N Engl J Med 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088. PMID: 25207766Free PMC Article

Therapy

Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Paietta E, Roberts KG, Wang V, Gu Z, Buck GAN, Pei D, Cheng C, Levine RL, Abdel-Wahab O, Cheng Z, Wu G, Qu C, Shi L, Pounds S, Willman CL, Harvey R, Racevskis J, Barinka J, Zhang Y, Dewald GW, Ketterling RP, Alejos D, Lazarus HM, Luger SM, Foroni L, Patel B, Fielding AK, Melnick A, Marks DI, Moorman AV, Wiernik PH, Rowe JM, Tallman MS, Goldstone AH, Mullighan CG, Litzow MR
Blood 2021 Sep 16;138(11):948-958. doi: 10.1182/blood.2020010144. PMID: 33895809Free PMC Article
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C
Blood 2021 Sep 2;138(9):773-784. doi: 10.1182/blood.2020010510. PMID: 33876209Free PMC Article
Magnani CF, Gaipa G, Lussana F, Belotti D, Gritti G, Napolitano S, Matera G, Cabiati B, Buracchi C, Borleri G, Fazio G, Zaninelli S, Tettamanti S, Cesana S, Colombo V, Quaroni M, Cazzaniga G, Rovelli A, Biagi E, Galimberti S, Calabria A, Benedicenti F, Montini E, Ferrari S, Introna M, Balduzzi A, Valsecchi MG, Dastoli G, Rambaldi A, Biondi A
J Clin Invest 2020 Nov 2;130(11):6021-6033. doi: 10.1172/JCI138473. PMID: 32780725Free PMC Article
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG
N Engl J Med 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088. PMID: 25207766Free PMC Article

Prognosis

Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2022 Sep;54(9):1376-1389. Epub 2022 Sep 1 doi: 10.1038/s41588-022-01159-z. PMID: 36050548Free PMC Article
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Paietta E, Roberts KG, Wang V, Gu Z, Buck GAN, Pei D, Cheng C, Levine RL, Abdel-Wahab O, Cheng Z, Wu G, Qu C, Shi L, Pounds S, Willman CL, Harvey R, Racevskis J, Barinka J, Zhang Y, Dewald GW, Ketterling RP, Alejos D, Lazarus HM, Luger SM, Foroni L, Patel B, Fielding AK, Melnick A, Marks DI, Moorman AV, Wiernik PH, Rowe JM, Tallman MS, Goldstone AH, Mullighan CG, Litzow MR
Blood 2021 Sep 16;138(11):948-958. doi: 10.1182/blood.2020010144. PMID: 33895809Free PMC Article
Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY
Proc Natl Acad Sci U S A 2018 Dec 11;115(50):E11711-E11720. Epub 2018 Nov 28 doi: 10.1073/pnas.1814397115. PMID: 30487223Free PMC Article
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183. Epub 2016 May 13 doi: 10.1016/j.ebiom.2016.04.038. PMID: 27428428Free PMC Article

Clinical prediction guides

Chen W, Shi H, Liu Z, Yang F, Liu J, Zhang L, Wu Y, Xia Y, Ou Y, Li R, Zhang T, Zhang J, Ke X, Hu K, Yu J
Clin Cancer Res 2023 Apr 14;29(8):1484-1495. doi: 10.1158/1078-0432.CCR-22-2924. PMID: 36735547
Zhang Y, Wang S, Zhang J, Liu C, Li X, Guo W, Duan Y, Chen X, Zong S, Zheng J, Wu Y, Chen X, Cheng X, Chang Y, Wang Y, Ding F, Yang W, Chen X, Guo Y, Zhang L, Chen Y, Zou Y, Zhu X, Gu J, Cheng T
Nat Cell Biol 2022 Feb;24(2):242-252. Epub 2022 Feb 10 doi: 10.1038/s41556-021-00814-7. PMID: 35145224
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Salmoiraghi S, Rambaldi A, Spinelli O
Leuk Lymphoma 2018 Apr;59(4):778-789. Epub 2017 Jul 6 doi: 10.1080/10428194.2017.1344839. PMID: 28679301
Lee SHR, Yang JJ
Best Pract Res Clin Haematol 2017 Sep;30(3):229-236. Epub 2017 Jul 27 doi: 10.1016/j.beha.2017.07.007. PMID: 29050696

Recent systematic reviews

Lobo-Alves SC, Oliveira LA, Kretzschmar GC, Valengo AE, Rosati R
Crit Rev Oncol Hematol 2024 Apr;196:104290. Epub 2024 Feb 8 doi: 10.1016/j.critrevonc.2024.104290. PMID: 38341118
Kołodrubiec J, Kozłowska M, Irga-Jaworska N, Sędek Ł, Pastorczak A, Trelińska J, Młynarski W
Leuk Res 2022 Oct;121:106925. Epub 2022 Aug 2 doi: 10.1016/j.leukres.2022.106925. PMID: 35939887
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429

Supplemental Content

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