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Abnormal fundus autofluorescence imaging

MedGen UID:: 892746
•Concept ID:: C4073073
•: Finding

HPO:	HP:0030602

Definition

Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal fundus autofluorescence imaging

Phenotypic abnormality
- Abnormality of the eye
  - Abnormal eye morphology
    - Abnormal posterior eye segment morphology
      - Abnormal posterior segment imaging
        Abnormal fundus autofluorescence imaging
        Hyperautofluorescent retinal lesion
        Hyperautofluorescent macular lesion
        Hypoautofluorescent retinal lesion
        Hypoautofluorescent macular lesion
        Perifoveal hypoautofluorescence
        Irregular central macular autofluorescence
        Perifoveal ring of hyperautofluorescence
        Perifoveal ring of hyperautofluorescence surrounded by abnormal autofluorescence
        Perifoveal ring of hyperautofluorescence surrounded by normal autofluorescence

Professional guidelines

PubMed

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.

Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766

Coats disease: An overview of classification, management and outcomes.

Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484 Free PMC Article

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.

Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109 Free PMC Article

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Recent clinical studies

Etiology

Incontinentia pigmenti and the eye.

Islam YFK, Khurshid SG
Curr Opin Ophthalmol 2022 Nov 1;33(6):525-531. Epub 2022 Jul 12 doi: 10.1097/ICU.0000000000000863. PMID: 35819905

Autofluorescence of blood and its application in biomedical and clinical research.

Shrirao AB, Schloss RS, Fritz Z, Shrirao MV, Rosen R, Yarmush ML
Biotechnol Bioeng 2021 Dec;118(12):4550-4576. Epub 2021 Sep 14 doi: 10.1002/bit.27933. PMID: 34487351

ULTRA-WIDE FIELD FUNDUS AUTOFLUORESCENCE IMAGING OF EYES WITH STICKLER SYNDROME.

Fujimoto K, Nagata T, Matsushita I, Oku K, Imagawa M, Kuniyoshi K, Hayashi T, Kimoto K, Ohji M, Kusaka S, Kondo H
Retina 2021 Mar 1;41(3):638-645. doi: 10.1097/IAE.0000000000002879. PMID: 32639332 Free PMC Article

Peripapillary Sparing in Autosomal Recessive Bestrophinopathy.

Birtel J, Gliem M, Herrmann P, MacLaren RE, Bolz HJ, Charbel Issa P
Ophthalmol Retina 2020 May;4(5):523-529. Epub 2020 Mar 5 doi: 10.1016/j.oret.2019.12.008. PMID: 32147488

Pachychoroid neovasculopathy.

Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

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Diagnosis

Clinical application of ultra-widefield fundus autofluorescence.

Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254

Posterior keratoconus.

Silas MR, Hilkert SM, Reidy JJ, Farooq AV
Br J Ophthalmol 2018 Jul;102(7):863-867. Epub 2017 Nov 9 doi: 10.1136/bjophthalmol-2017-311097. PMID: 29122822

Fundus autofluorescence imaging in hereditary retinal diseases.

Pichi F, Abboud EB, Ghazi NG, Khan AO
Acta Ophthalmol 2018 Aug;96(5):e549-e561. Epub 2017 Nov 2 doi: 10.1111/aos.13602. PMID: 29098804

Pachychoroid neovasculopathy.

Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

Ophthalmic imaging.

Ilginis T, Clarke J, Patel PJ
Br Med Bull 2014 Sep;111(1):77-88. Epub 2014 Aug 18 doi: 10.1093/bmb/ldu022. PMID: 25139430

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Therapy

Surgical Management of Diabetic Macular Edema.

Prince J, Kumar D, Ghosh A, Arevalo JF, Zhang AY
Curr Diab Rep 2023 Jun;23(6):119-125. Epub 2023 Apr 12 doi: 10.1007/s11892-023-01505-3. PMID: 37043090

Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.

Komatsu H, Onoguchi G, Jerotic S, Kanahara N, Kakuto Y, Ono T, Funakoshi S, Yabana T, Nakazawa T, Tomita H
Mol Psychiatry 2022 Sep;27(9):3592-3616. Epub 2022 May 2 doi: 10.1038/s41380-022-01591-x. PMID: 35501407

Imaging endpoints for clinical trials in MacTel type 2.

Pauleikhoff D, Pauleikhoff L, Chew EY
Eye (Lond) 2022 Feb;36(2):284-293. Epub 2021 Aug 13 doi: 10.1038/s41433-021-01723-7. PMID: 34389818 Free PMC Article

Quantitative Fundus Autofluorescence in HCQ Retinopathy.

Greenstein VC, Lima de Carvalho JR Jr, Parmann R, Amaro-Quireza L, Lee W, Hood DC, Tsang SH, Sparrow JR
Invest Ophthalmol Vis Sci 2020 Sep 1;61(11):41. doi: 10.1167/iovs.61.11.41. PMID: 32976563 Free PMC Article

Novel endoscopic diagnosis for bladder cancer.

Lerner SP, Goh A
Cancer 2015 Jan 15;121(2):169-78. Epub 2014 Aug 5 doi: 10.1002/cncr.28905. PMID: 25132313

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Prognosis

Fundus Autofluorescence in Posterior and Panuveitis-An Under-Estimated Imaging Technique: A Review and Case Series.

Mauschitz MM, Zeller M, Sagar P, Biswal S, Guzman G, Terheyden JH, Meyer CH, Holz FG, Heinz C, Pleyer U, Finger RP, Wintergerst MWM
Biomolecules 2024 Apr 25;14(5) doi: 10.3390/biom14050515. PMID: 38785922

Normal and abnormal foveal development.

Thomas MG, Papageorgiou E, Kuht HJ, Gottlob I
Br J Ophthalmol 2022 May;106(5):593-599. Epub 2020 Nov 4 doi: 10.1136/bjophthalmol-2020-316348. PMID: 33148537

Quantitative Fundus Autofluorescence in ABCA4-Related Retinopathy -Functional Relevance and Genotype-Phenotype Correlation.

Müller PL, Gliem M, McGuinnes M, Birtel J, Holz FG, Charbel Issa P
Am J Ophthalmol 2021 Feb;222:340-350. Epub 2020 Sep 4 doi: 10.1016/j.ajo.2020.08.042. PMID: 32891696

ULTRA-WIDE FIELD FUNDUS AUTOFLUORESCENCE IMAGING OF EYES WITH STICKLER SYNDROME.

Macular corneal dystrophy: A review.

Aggarwal S, Peck T, Golen J, Karcioglu ZA
Surv Ophthalmol 2018 Sep-Oct;63(5):609-617. Epub 2018 Mar 28 doi: 10.1016/j.survophthal.2018.03.004. PMID: 29604391

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Clinical prediction guides

Normal and abnormal foveal development.

Thomas MG, Papageorgiou E, Kuht HJ, Gottlob I
Br J Ophthalmol 2022 May;106(5):593-599. Epub 2020 Nov 4 doi: 10.1136/bjophthalmol-2020-316348. PMID: 33148537

Quantitative Fundus Autofluorescence in ABCA4-Related Retinopathy -Functional Relevance and Genotype-Phenotype Correlation.

Müller PL, Gliem M, McGuinnes M, Birtel J, Holz FG, Charbel Issa P
Am J Ophthalmol 2021 Feb;222:340-350. Epub 2020 Sep 4 doi: 10.1016/j.ajo.2020.08.042. PMID: 32891696

ULTRA-WIDE FIELD FUNDUS AUTOFLUORESCENCE IMAGING OF EYES WITH STICKLER SYNDROME.

Classification of fundus autofluorescence abnormal patterns in diabetic macular edema.

Mota SH, Lima-Gómez V, Rodríguez-Ayala E, Fromow-Guerra JJ, Melo-Granados EAR
Gac Med Mex 2019;155(5):458-462. doi: 10.24875/GMM.M20000332. PMID: 32091016

Pachychoroid neovasculopathy.

Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

See all (1958)

Recent systematic reviews

Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.

Clinical application of ultra-widefield fundus autofluorescence.

Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254

Spectrum of pachychoroid diseases.

Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279

β-Thalassemia and ocular implications: a systematic review.

Liaska A, Petrou P, Georgakopoulos CD, Diamanti R, Papaconstantinou D, Kanakis MG, Georgalas I
BMC Ophthalmol 2016 Jul 8;16:102. doi: 10.1186/s12886-016-0285-2. PMID: 27390837 Free PMC Article

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.

Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109 Free PMC Article

See all (29)

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Abnormal fundus autofluorescence imaging

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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