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Decreased circulating androgen concentration

MedGen UID:
892773
•Concept ID:
C4072894
•
Finding
Synonym: Decreased circulating androgen level
 
HPO: HP:0030349

Definition

A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone. [from HPO]

Professional guidelines

PubMed

The role of testosterone in menopausal hormone treatment. What is the evidence?
Johansen N, Lindén Hirschberg A, Moen MH
Acta Obstet Gynecol Scand 2020 Aug;99(8):966-969. Epub 2020 Mar 2 doi: 10.1111/aogs.13819. PMID: 32027015
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials.
Yeap BB, Page ST, Grossmann M
Lancet Diabetes Endocrinol 2018 Aug;6(8):659-672. Epub 2018 Jul 17 doi: 10.1016/S2213-8587(17)30416-3. PMID: 30017800
Hormone treatment and muscle anabolism during aging: androgens.
Dillon EL, Durham WJ, Urban RJ, Sheffield-Moore M
Clin Nutr 2010 Dec;29(6):697-700. Epub 2010 May 7 doi: 10.1016/j.clnu.2010.03.010. PMID: 20452103Free PMC Article

Recent clinical studies

Etiology

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Bone health in ageing men.
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Would male hormonal contraceptives affect cardiovascular risk?
Zitzmann M
Asian J Androl 2018 Mar-Apr;20(2):145-148. doi: 10.4103/aja.aja_2_18. PMID: 29384141Free PMC Article
Science of intracrinology in postmenopausal women.
Labrie F, Bélanger A, Pelletier G, Martel C, Archer DF, Utian WH
Menopause 2017 Jun;24(6):702-712. doi: 10.1097/GME.0000000000000808. PMID: 28098598
Circulating androgens in women: exercise-induced changes.
Enea C, Boisseau N, Fargeas-Gluck MA, Diaz V, Dugué B
Sports Med 2011 Jan 1;41(1):1-15. doi: 10.2165/11536920-000000000-00000. PMID: 21142281

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Hypogonadismus obézních muž&#367.
Stárka L, Dušková M, Hill M
Vnitr Lek 2020 Winter;66(8):24-27. PMID: 33740856
Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome.
Franik G, Plinta R, Madej P, Owczarek A, Bozentowicz-Wikarek M, Chudek J, Skrzypulec-Plinta V, Olszanecka-Glinianowicz M
Ginekol Pol 2020;91(5):251-255. doi: 10.5603/GP.2020.0056. PMID: 32495930
Perspectives for metabolomics in testosterone replacement therapy.
Haring R
J Endocrinol 2012 Oct;215(1):3-16. Epub 2012 Apr 30 doi: 10.1530/JOE-12-0119. PMID: 22547567
Hirsutism, its pathogenesis.
Breckwoldt M, Zahradnik HP, Wieacker P
Hum Reprod 1989 Aug;4(6):601-4. doi: 10.1093/oxfordjournals.humrep.a136950. PMID: 2674189

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Bone health in ageing men.
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Would male hormonal contraceptives affect cardiovascular risk?
Zitzmann M
Asian J Androl 2018 Mar-Apr;20(2):145-148. doi: 10.4103/aja.aja_2_18. PMID: 29384141Free PMC Article
Exogenous Androgens and Male Reproduction.
Drobnis EZ, Nangia AK
Adv Exp Med Biol 2017;1034:25-28. doi: 10.1007/978-3-319-69535-8_4. PMID: 29256124
Science of intracrinology in postmenopausal women.
Labrie F, Bélanger A, Pelletier G, Martel C, Archer DF, Utian WH
Menopause 2017 Jun;24(6):702-712. doi: 10.1097/GME.0000000000000808. PMID: 28098598

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome.
Franik G, Plinta R, Madej P, Owczarek A, Bozentowicz-Wikarek M, Chudek J, Skrzypulec-Plinta V, Olszanecka-Glinianowicz M
Ginekol Pol 2020;91(5):251-255. doi: 10.5603/GP.2020.0056. PMID: 32495930
Do hormone manipulations reduce fitness? A meta-analytic test of the Optimal Endocrine Phenotype Hypothesis.
Bonier F, Cox RM
Mol Cell Endocrinol 2020 Jan 15;500:110640. Epub 2019 Nov 9 doi: 10.1016/j.mce.2019.110640. PMID: 31715223
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials.
Yeap BB, Page ST, Grossmann M
Lancet Diabetes Endocrinol 2018 Aug;6(8):659-672. Epub 2018 Jul 17 doi: 10.1016/S2213-8587(17)30416-3. PMID: 30017800
Perspectives for metabolomics in testosterone replacement therapy.
Haring R
J Endocrinol 2012 Oct;215(1):3-16. Epub 2012 Apr 30 doi: 10.1530/JOE-12-0119. PMID: 22547567

Clinical prediction guides

Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.
Bergamini M, Dalla Volta A, Palumbo C, Zamboni S, Triggiani L, Zamparini M, Laganà M, Rinaudo L, Di Meo N, Caramella I, Bresciani R, Valcamonico F, Borghetti P, Guerini A, Farina D, Antonelli A, Simeone C, Mazziotti G, Berruti A
Elife 2024 Apr 24;13 doi: 10.7554/eLife.92655. PMID: 38656229Free PMC Article
Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome.
Franik G, Plinta R, Madej P, Owczarek A, Bozentowicz-Wikarek M, Chudek J, Skrzypulec-Plinta V, Olszanecka-Glinianowicz M
Ginekol Pol 2020;91(5):251-255. doi: 10.5603/GP.2020.0056. PMID: 32495930
Circulating androgens in women: exercise-induced changes.
Enea C, Boisseau N, Fargeas-Gluck MA, Diaz V, Dugué B
Sports Med 2011 Jan 1;41(1):1-15. doi: 10.2165/11536920-000000000-00000. PMID: 21142281
Testosterone and atherosclerosis.
Eckardstein Av, Wu FC
Growth Horm IGF Res 2003 Aug;13 Suppl A:S72-84. doi: 10.1016/s1096-6374(03)00059-5. PMID: 12914731
Adrenarche.
Parker LN
Endocrinol Metab Clin North Am 1991 Mar;20(1):71-83. PMID: 2029889

Recent systematic reviews

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Prevalence of 'obesity-associated gonadal dysfunction' in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis.
Escobar-Morreale HF, Santacruz E, Luque-Ramírez M, Botella Carretero JI
Hum Reprod Update 2017 Jul 1;23(4):390-408. doi: 10.1093/humupd/dmx012. PMID: 28486593
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials.
Ennour-Idrissi K, Maunsell E, Diorio C
Breast Cancer Res 2015 Nov 5;17(1):139. doi: 10.1186/s13058-015-0647-3. PMID: 26541144Free PMC Article
The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis.
Zimmerman Y, Eijkemans MJ, Coelingh Bennink HJ, Blankenstein MA, Fauser BC
Hum Reprod Update 2014 Jan-Feb;20(1):76-105. Epub 2013 Sep 29 doi: 10.1093/humupd/dmt038. PMID: 24082040Free PMC Article
Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis.
Kelly CJ, Stenton SR, Lashen H
Hum Reprod Update 2011 Jan-Feb;17(1):4-16. Epub 2010 Jul 15 doi: 10.1093/humupd/dmq027. PMID: 20634211

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