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Increased circulating androgen concentration

MedGen UID:
892873
•Concept ID:
C4072893
•
Finding
Synonyms: Hyperandrogenemia; Increased circulating androgen level
 
HPO: HP:0030348

Definition

An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating androgen concentration

Professional guidelines

PubMed

Hormone treatment and muscle anabolism during aging: androgens.
Dillon EL, Durham WJ, Urban RJ, Sheffield-Moore M
Clin Nutr 2010 Dec;29(6):697-700. Epub 2010 May 7 doi: 10.1016/j.clnu.2010.03.010. PMID: 20452103Free PMC Article
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Menopausal endocrinology and management.
Korenman SG
Arch Intern Med 1982 Jun;142(6):1131-6. PMID: 7046670

Recent clinical studies

Etiology

Bone health in ageing men.
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.
Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J
Environ Int 2021 Apr;149:106408. Epub 2021 Feb 3 doi: 10.1016/j.envint.2021.106408. PMID: 33548847
Why is understanding the relationship of testosterone to cardiovascular risk so important?
Yeap BB, Anawalt BD
Asian J Androl 2018 Mar-Apr;20(2):107-108. doi: 10.4103/aja.aja_71_17. PMID: 29405170Free PMC Article
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Testosterone dose-response relationships in healthy young men.
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW
Am J Physiol Endocrinol Metab 2001 Dec;281(6):E1172-81. doi: 10.1152/ajpendo.2001.281.6.E1172. PMID: 11701431

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Testosterone analysis in prostate cancer patients.
van Winden LJ, van Rossum HH
Adv Clin Chem 2022;108:73-104. Epub 2021 Aug 23 doi: 10.1016/bs.acc.2021.07.007. PMID: 35659062
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Perspectives for metabolomics in testosterone replacement therapy.
Haring R
J Endocrinol 2012 Oct;215(1):3-16. Epub 2012 Apr 30 doi: 10.1530/JOE-12-0119. PMID: 22547567
Hirsutism, its pathogenesis.
Breckwoldt M, Zahradnik HP, Wieacker P
Hum Reprod 1989 Aug;4(6):601-4. doi: 10.1093/oxfordjournals.humrep.a136950. PMID: 2674189

Therapy

Bone health in ageing men.
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Androgens, aging, and prostate health.
Welén K, Damber JE
Rev Endocr Metab Disord 2022 Dec;23(6):1221-1231. Epub 2022 Jun 24 doi: 10.1007/s11154-022-09730-z. PMID: 35748976Free PMC Article
Testosterone analysis in prostate cancer patients.
van Winden LJ, van Rossum HH
Adv Clin Chem 2022;108:73-104. Epub 2021 Aug 23 doi: 10.1016/bs.acc.2021.07.007. PMID: 35659062
Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.
van der Merwe J, Brooks NE, Myburgh KH
Clin J Sport Med 2009 Sep;19(5):399-404. doi: 10.1097/JSM.0b013e3181b8b52f. PMID: 19741313
Testosterone dose-response relationships in healthy young men.
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW
Am J Physiol Endocrinol Metab 2001 Dec;281(6):E1172-81. doi: 10.1152/ajpendo.2001.281.6.E1172. PMID: 11701431

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies.
Mustieles V, Balogh RK, Axelstad M, Montazeri P, Márquez S, Vrijheid M, Draskau MK, Taxvig C, Peinado FM, Berman T, Frederiksen H, Fernández MF, Marie Vinggaard A, Andersson AM
Environ Int 2023 Mar;173:107739. Epub 2023 Jan 6 doi: 10.1016/j.envint.2023.107739. PMID: 36805158
Hypogonadism and male obesity: Focus on unresolved questions.
Grossmann M
Clin Endocrinol (Oxf) 2018 Jul;89(1):11-21. Epub 2018 May 16 doi: 10.1111/cen.13723. PMID: 29683196
Estrogen and bone health in men and women.
Cauley JA
Steroids 2015 Jul;99(Pt A):11-5. Epub 2014 Dec 30 doi: 10.1016/j.steroids.2014.12.010. PMID: 25555470
Perspectives for metabolomics in testosterone replacement therapy.
Haring R
J Endocrinol 2012 Oct;215(1):3-16. Epub 2012 Apr 30 doi: 10.1530/JOE-12-0119. PMID: 22547567

Clinical prediction guides

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Gonadal steroids and humoral immunity.
Sakiani S, Olsen NJ, Kovacs WJ
Nat Rev Endocrinol 2013 Jan;9(1):56-62. Epub 2012 Nov 27 doi: 10.1038/nrendo.2012.206. PMID: 23183675
Effect of vitamin D supplementation on testosterone levels in men.
Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A
Horm Metab Res 2011 Mar;43(3):223-5. Epub 2010 Dec 10 doi: 10.1055/s-0030-1269854. PMID: 21154195
Testosterone physiology in resistance exercise and training: the up-stream regulatory elements.
Vingren JL, Kraemer WJ, Ratamess NA, Anderson JM, Volek JS, Maresh CM
Sports Med 2010 Dec 1;40(12):1037-53. doi: 10.2165/11536910-000000000-00000. PMID: 21058750
Adrenarche.
Parker LN
Endocrinol Metab Clin North Am 1991 Mar;20(1):71-83. PMID: 2029889

Recent systematic reviews

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Prevalence of 'obesity-associated gonadal dysfunction' in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis.
Escobar-Morreale HF, Santacruz E, Luque-Ramírez M, Botella Carretero JI
Hum Reprod Update 2017 Jul 1;23(4):390-408. doi: 10.1093/humupd/dmx012. PMID: 28486593
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials.
Ennour-Idrissi K, Maunsell E, Diorio C
Breast Cancer Res 2015 Nov 5;17(1):139. doi: 10.1186/s13058-015-0647-3. PMID: 26541144Free PMC Article
The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis.
Zimmerman Y, Eijkemans MJ, Coelingh Bennink HJ, Blankenstein MA, Fauser BC
Hum Reprod Update 2014 Jan-Feb;20(1):76-105. Epub 2013 Sep 29 doi: 10.1093/humupd/dmt038. PMID: 24082040Free PMC Article
Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis.
Kelly CJ, Stenton SR, Lashen H
Hum Reprod Update 2011 Jan-Feb;17(1):4-16. Epub 2010 Jul 15 doi: 10.1093/humupd/dmq027. PMID: 20634211

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