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Propofol Infusion Syndrome

MedGen UID:
896523
•Concept ID:
C1328409
•
Disease or Syndrome
Synonyms: Propofol Infusion Syndromes; Propofol Related Infusion Syndrome; Propofol Syndrome; Propofol Syndromes; Propofol-Related Infusion Syndrome; Propofol-Related Infusion Syndromes

Definition

Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPropofol Infusion Syndrome

Professional guidelines

PubMed

Anaesthetic management of patients with myopathies.
Schieren M, Defosse J, Böhmer A, Wappler F, Gerbershagen MU
Eur J Anaesthesiol 2017 Oct;34(10):641-649. doi: 10.1097/EJA.0000000000000672. PMID: 28719515
Propofol versus thiopental sodium for the treatment of refractory status epilepticus.
Prabhakar H, Kalaivani M
Cochrane Database Syst Rev 2017 Feb 3;2(2):CD009202. doi: 10.1002/14651858.CD009202.pub4. PMID: 28155226Free PMC Article
The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment.
Papaioannou V, Dragoumanis C, Theodorou V, Pneumatikos I
Acta Anaesthesiol Belg 2008;59(2):79-86. PMID: 18652104

Recent clinical studies

Etiology

Suspected propofol infusion syndrome during normal targeted propofol concentration.
Ichikawa T, Okuyama K, Kamata K, Masui K, Ozaki M
J Anesth 2020 Aug;34(4):619-623. Epub 2020 Mar 28 doi: 10.1007/s00540-020-02773-z. PMID: 32222909
Propofol infusion syndrome: a structured literature review and analysis of published case reports.
Hemphill S, McMenamin L, Bellamy MC, Hopkins PM
Br J Anaesth 2019 Apr;122(4):448-459. Epub 2019 Feb 6 doi: 10.1016/j.bja.2018.12.025. PMID: 30857601Free PMC Article
Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy.
Riera AR, Uchida AH, Schapachnik E, Dubner S, Filho CF, Ferreira C
Cardiol J 2010;17(2):130-5. PMID: 20544610
Propofol infusion syndrome.
Rajda C, Dereczyk D, Kunkel P
J Trauma Nurs 2008 Jul-Sep;15(3):118-22. doi: 10.1097/01.JTN.0000337153.08464.0f. PMID: 18820559
Propofol infusion syndrome.
Kam PC, Cardone D
Anaesthesia 2007 Jul;62(7):690-701. doi: 10.1111/j.1365-2044.2007.05055.x. PMID: 17567345

Diagnosis

The incidence of propofol infusion syndrome in critically-ill patients.
Li WK, Chen XJC, Altshuler D, Islam S, Spiegler P, Emerson L, Bender M
J Crit Care 2022 Oct;71:154098. Epub 2022 Jun 17 doi: 10.1016/j.jcrc.2022.154098. PMID: 35724444
Propofol infusion syndrome: a structured literature review and analysis of published case reports.
Hemphill S, McMenamin L, Bellamy MC, Hopkins PM
Br J Anaesth 2019 Apr;122(4):448-459. Epub 2019 Feb 6 doi: 10.1016/j.bja.2018.12.025. PMID: 30857601Free PMC Article
Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder.
Finsterer J, Frank M
J Child Neurol 2016 Nov;31(13):1489-1494. Epub 2016 Aug 3 doi: 10.1177/0883073816661458. PMID: 27488955
Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.
Krajčová A, Waldauf P, Anděl M, Duška F
Crit Care 2015 Nov 12;19:398. doi: 10.1186/s13054-015-1112-5. PMID: 26558513Free PMC Article
Propofol infusion syndrome.
Rajda C, Dereczyk D, Kunkel P
J Trauma Nurs 2008 Jul-Sep;15(3):118-22. doi: 10.1097/01.JTN.0000337153.08464.0f. PMID: 18820559

Therapy

Suspected propofol infusion syndrome during normal targeted propofol concentration.
Ichikawa T, Okuyama K, Kamata K, Masui K, Ozaki M
J Anesth 2020 Aug;34(4):619-623. Epub 2020 Mar 28 doi: 10.1007/s00540-020-02773-z. PMID: 32222909
Propofol infusion syndrome: a structured literature review and analysis of published case reports.
Hemphill S, McMenamin L, Bellamy MC, Hopkins PM
Br J Anaesth 2019 Apr;122(4):448-459. Epub 2019 Feb 6 doi: 10.1016/j.bja.2018.12.025. PMID: 30857601Free PMC Article
Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy.
Riera AR, Uchida AH, Schapachnik E, Dubner S, Filho CF, Ferreira C
Cardiol J 2010;17(2):130-5. PMID: 20544610
Propofol infusion syndrome.
Rajda C, Dereczyk D, Kunkel P
J Trauma Nurs 2008 Jul-Sep;15(3):118-22. doi: 10.1097/01.JTN.0000337153.08464.0f. PMID: 18820559
Propofol infusion syndrome.
Kam PC, Cardone D
Anaesthesia 2007 Jul;62(7):690-701. doi: 10.1111/j.1365-2044.2007.05055.x. PMID: 17567345

Prognosis

The incidence of propofol infusion syndrome in critically-ill patients.
Li WK, Chen XJC, Altshuler D, Islam S, Spiegler P, Emerson L, Bender M
J Crit Care 2022 Oct;71:154098. Epub 2022 Jun 17 doi: 10.1016/j.jcrc.2022.154098. PMID: 35724444
Suspected propofol infusion syndrome during normal targeted propofol concentration.
Ichikawa T, Okuyama K, Kamata K, Masui K, Ozaki M
J Anesth 2020 Aug;34(4):619-623. Epub 2020 Mar 28 doi: 10.1007/s00540-020-02773-z. PMID: 32222909
Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.
Krajčová A, Waldauf P, Anděl M, Duška F
Crit Care 2015 Nov 12;19:398. doi: 10.1186/s13054-015-1112-5. PMID: 26558513Free PMC Article
Propofol infusion syndrome: update of clinical manifestation and pathophysiology.
Fudickar A, Bein B
Minerva Anestesiol 2009 May;75(5):339-44. PMID: 19412155
Propofol-infusion syndrome in children.
Hatch DJ
Lancet 1999 Apr 3;353(9159):1117-8. doi: 10.1016/S0140-6736(99)90018-1. PMID: 10209973

Clinical prediction guides

Modeling propofol-induced cardiotoxicity in the isolated-perfused newborn mouse heart.
Barajas MB, Wang A, Griffiths KK, Sun L, Yang G, Levy RJ
Physiol Rep 2022 Aug;10(15):e15402. doi: 10.14814/phy2.15402. PMID: 35923108Free PMC Article
The incidence of propofol infusion syndrome in critically-ill patients.
Li WK, Chen XJC, Altshuler D, Islam S, Spiegler P, Emerson L, Bender M
J Crit Care 2022 Oct;71:154098. Epub 2022 Jun 17 doi: 10.1016/j.jcrc.2022.154098. PMID: 35724444
Suspected propofol infusion syndrome during normal targeted propofol concentration.
Ichikawa T, Okuyama K, Kamata K, Masui K, Ozaki M
J Anesth 2020 Aug;34(4):619-623. Epub 2020 Mar 28 doi: 10.1007/s00540-020-02773-z. PMID: 32222909
Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome.
Sun L, Ma W, Gao W, Xing Y, Chen L, Xia Z, Zhang Z, Dai Z
Cell Death Dis 2019 Jul 17;10(8):542. doi: 10.1038/s41419-019-1761-4. PMID: 31316052Free PMC Article
Treatment strategies for refractory status epilepticus.
Holtkamp M
Curr Opin Crit Care 2011 Apr;17(2):94-100. doi: 10.1097/MCC.0b013e328342fab5. PMID: 21178612

Recent systematic reviews

Propofol use in newborns and children: is it safe? A systematic review.
Filho EM, Riechelmann MB
J Pediatr (Rio J) 2020 May-Jun;96(3):289-309. Epub 2020 Jan 8 doi: 10.1016/j.jped.2019.08.011. PMID: 31926134Free PMC Article
Propofol versus thiopental sodium for the treatment of refractory status epilepticus.
Prabhakar H, Kalaivani M
Cochrane Database Syst Rev 2017 Feb 3;2(2):CD009202. doi: 10.1002/14651858.CD009202.pub4. PMID: 28155226Free PMC Article

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