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Reduced plasminogen activator inhibitor 1 antigen

MedGen UID:
897922
•Concept ID:
C4280699
•
Finding
HPO: HP:0040249

Definition

Reduced level of plasminogen activator inhibitor 1 antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasminogen activator inhibitor 1 antigen

Professional guidelines

PubMed

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Insulin treatment improves microalbuminuria and other cardiovascular risk factors in patients with type 2 diabetes mellitus.
Lindström T, Olsson AG, von Schenck H, Wallentin L, Arnqvist HJ
J Intern Med 1994 Mar;235(3):253-61. doi: 10.1111/j.1365-2796.1994.tb01069.x. PMID: 8120522
Plasma t-PA and PAl-1 antigen concentrations in non-insulin dependent diabetic patients: effects of treatment modality on fibrinolysis.
Cho YW, Yang DH, Oh DY, Baick SH, Kim SK, Kim SJ, Hong SY
Korean J Intern Med 1992 Jul;7(2):81-6. doi: 10.3904/kjim.1992.7.2.81. PMID: 1306076Free PMC Article

Recent clinical studies

Etiology

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma.
Dan J, Belyea D, Gertner G, Leshem I, Lusky M, Miskin R
Arch Ophthalmol 2005 Feb;123(2):220-4. doi: 10.1001/archopht.123.2.220. PMID: 15710819
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668

Diagnosis

Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome.
Wang L, Rockwood J, Zak D, Devaraj S, Jialal I
Metab Syndr Relat Disord 2008 Jun;6(2):149-52. doi: 10.1089/met.2008.0012. PMID: 18484901Free PMC Article
Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ
Circulation 2007 Sep 11;116(11 Suppl):I1-7. doi: 10.1161/CIRCULATIONAHA.106.677906. PMID: 17846288
Neisseria meningitidis lipopolysaccharides in human pathology.
Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P
J Endotoxin Res 2001;7(6):401-20. PMID: 11753210

Therapy

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668
Neisseria meningitidis lipopolysaccharides in human pathology.
Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P
J Endotoxin Res 2001;7(6):401-20. PMID: 11753210

Prognosis

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ
Circulation 2007 Sep 11;116(11 Suppl):I1-7. doi: 10.1161/CIRCULATIONAHA.106.677906. PMID: 17846288
Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors.
Xiang G, Schuster MD, Seki T, Kocher AA, Eshghi S, Boyle A, Itescu S
J Exp Med 2004 Dec 20;200(12):1657-66. Epub 2004 Dec 13 doi: 10.1084/jem.20040221. PMID: 15596522Free PMC Article
Dyslipidemias and fibrinolysis.
Puccetti L, Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Auteri A
Ital Heart J 2002 Oct;3(10):579-86. PMID: 12478815

Clinical prediction guides

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
CD40L/CD40 Regulates Adipokines and Cytokines by H3K4me3 Modification in Epicardial Adipocytes.
Yuan M, Wu B, Zhang L, Wang H, Yang Y
J Cardiovasc Pharmacol 2021 Aug 1;78(2):228-234. doi: 10.1097/FJC.0000000000001060. PMID: 34029270
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.
Bhandary YP, Shetty SK, Marudamuthu AS, Midde KK, Ji HL, Shams H, Subramaniam R, Fu J, Idell S, Shetty S
PLoS One 2015;10(5):e0123187. Epub 2015 May 1 doi: 10.1371/journal.pone.0123187. PMID: 25932922Free PMC Article
Interferon γ and plasminogen activator inhibitor 1 regulate adhesion formation after partial hepatectomy.
Ohashi K, Yoshimoto T, Kosaka H, Hirano T, Iimuro Y, Nakanishi K, Fujimoto J
Br J Surg 2014 Mar;101(4):398-407. doi: 10.1002/bjs.9405. PMID: 24536011

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