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Reduced plasminogen activator inhibitor 1 antigen

MedGen UID:
897922
•Concept ID:
C4280699
•
Finding
HPO: HP:0040249

Definition

Reduced level of plasminogen activator inhibitor 1 antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasminogen activator inhibitor 1 antigen

Professional guidelines

PubMed

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults.
Johansson JO, Landin K, Johannsson G, Tengborn L, Bengtsson BA
Thromb Haemost 1996 Sep;76(3):422-8. PMID: 8883281
Insulin treatment improves microalbuminuria and other cardiovascular risk factors in patients with type 2 diabetes mellitus.
Lindström T, Olsson AG, von Schenck H, Wallentin L, Arnqvist HJ
J Intern Med 1994 Mar;235(3):253-61. doi: 10.1111/j.1365-2796.1994.tb01069.x. PMID: 8120522

Recent clinical studies

Etiology

SGLT-2 inhibition by empagliflozin has no effect on experimental arterial thrombosis in a murine model of low-grade inflammation.
Liberale L, Kraler S, Puspitasari YM, Bonetti NR, Akhmedov A, Ministrini S, Montecucco F, Marx N, Lehrke M, Hartmann NK, Beer JH, Wenzl FA, Paneni F, Lüscher TF, Camici GG
Cardiovasc Res 2023 May 2;119(3):843-856. doi: 10.1093/cvr/cvac126. PMID: 35993135
Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma.
Dan J, Belyea D, Gertner G, Leshem I, Lusky M, Miskin R
Arch Ophthalmol 2005 Feb;123(2):220-4. doi: 10.1001/archopht.123.2.220. PMID: 15710819
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668

Diagnosis

Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome.
Wang L, Rockwood J, Zak D, Devaraj S, Jialal I
Metab Syndr Relat Disord 2008 Jun;6(2):149-52. doi: 10.1089/met.2008.0012. PMID: 18484901Free PMC Article
Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ
Circulation 2007 Sep 11;116(11 Suppl):I1-7. doi: 10.1161/CIRCULATIONAHA.106.677906. PMID: 17846288
Neisseria meningitidis lipopolysaccharides in human pathology.
Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P
J Endotoxin Res 2001;7(6):401-20. PMID: 11753210

Therapy

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
SGLT-2 inhibition by empagliflozin has no effect on experimental arterial thrombosis in a murine model of low-grade inflammation.
Liberale L, Kraler S, Puspitasari YM, Bonetti NR, Akhmedov A, Ministrini S, Montecucco F, Marx N, Lehrke M, Hartmann NK, Beer JH, Wenzl FA, Paneni F, Lüscher TF, Camici GG
Cardiovasc Res 2023 May 2;119(3):843-856. doi: 10.1093/cvr/cvac126. PMID: 35993135
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668

Prognosis

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ
Circulation 2007 Sep 11;116(11 Suppl):I1-7. doi: 10.1161/CIRCULATIONAHA.106.677906. PMID: 17846288
Niacin affects cell adhesion molecules and plasminogen activator inhibitor-1 in HepG2 cells.
Tavintharan S, Sivakumar M, Lim SC, Sum CF
Clin Chim Acta 2007 Feb;376(1-2):41-4. Epub 2006 Jul 14 doi: 10.1016/j.cca.2006.07.009. PMID: 16916501
Dyslipidemias and fibrinolysis.
Puccetti L, Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Auteri A
Ital Heart J 2002 Oct;3(10):579-86. PMID: 12478815

Clinical prediction guides

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
CD40L/CD40 Regulates Adipokines and Cytokines by H3K4me3 Modification in Epicardial Adipocytes.
Yuan M, Wu B, Zhang L, Wang H, Yang Y
J Cardiovasc Pharmacol 2021 Aug 1;78(2):228-234. doi: 10.1097/FJC.0000000000001060. PMID: 34029270
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.
Bhandary YP, Shetty SK, Marudamuthu AS, Midde KK, Ji HL, Shams H, Subramaniam R, Fu J, Idell S, Shetty S
PLoS One 2015;10(5):e0123187. Epub 2015 May 1 doi: 10.1371/journal.pone.0123187. PMID: 25932922Free PMC Article
A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes.
Zhang J, Gu C, Lawrence DA, Cheung AK, Huang Y
Exp Physiol 2014 May 1;99(5):802-15. Epub 2014 Jan 17 doi: 10.1113/expphysiol.2013.077610. PMID: 24443353Free PMC Article

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