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Modic type I vertebral endplate changes

MedGen UID:
898817
•Concept ID:
C4280777
•
Finding
Synonym: Modic type 1 vertebral endplate changes
 
HPO: HP:0030776

Definition

An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModic type I vertebral endplate changes

Professional guidelines

PubMed

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.
Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

Recent clinical studies

Etiology

The impact of dyslipidemia on lumbar intervertebral disc degeneration and vertebral endplate modic changes: a cross-sectional study of 1035 citizens in China.
Yuan L, Huang Z, Han W, Chang R, Sun B, Zhu M, Li C, Yan J, Liu B, Yin H, Ye W
BMC Public Health 2023 Jul 6;23(1):1302. doi: 10.1186/s12889-023-16224-3. PMID: 37415123Free PMC Article
Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.
ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347
Modic Change: An Emerging Complication in the Aging Population.
Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981
Association Between Vertebral Dimensions and Lumbar Modic Changes.
Julin M, Saukkonen J, Oura P, Junno JA, Niemelä M, Määttä J, Niinimäki J, Jämsä T, Korpelainen R, Karppinen J
Spine (Phila Pa 1976) 2021 Apr 1;46(7):E415-E425. doi: 10.1097/BRS.0000000000003797. PMID: 33692323

Diagnosis

Degenerative disease of the spine: How to relate clinical symptoms to radiological findings.
Sąsiadek M, Jacków-Nowicka J
Adv Clin Exp Med 2024 Jan;33(1):91-98. doi: 10.17219/acem/163357. PMID: 37549011
A definition and clinical grading of Modic changes.
Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328
Modic Change: An Emerging Complication in the Aging Population.
Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521
Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845Free PMC Article

Therapy

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
Are Modic changes 'Primary infective endplatitis'?-insights from multimodal imaging of non-specific low back pain patients and development of a radiological 'Endplate infection probability score'.
Rajasekaran S, Pushpa BT, Soundararajan DCR, Sri Vijay Anand KS, Murugan C, Nedunchelian M, Kanna RM, Shetty AP, Tangavel C, Muthurajan R
Eur Spine J 2022 Nov;31(11):2884-2896. Epub 2022 Aug 5 doi: 10.1007/s00586-022-07335-3. PMID: 35931790
Association Between Modic Changes and Low Back Pain in Middle Age: A Northern Finland Birth Cohort Study.
Saukkonen J, Määttä J, Oura P, Kyllönen E, Tervonen O, Niinimäki J, Auvinen J, Karppinen J
Spine (Phila Pa 1976) 2020 Oct 1;45(19):1360-1367. doi: 10.1097/BRS.0000000000003529. PMID: 32341297
Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.
Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816

Prognosis

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
Presence of preoperative Modic changes and severity of endplate damage score are independent risk factors for developing postoperative surgical site infection: a retrospective case-control study of 1124 patients.
Pradip IA, Dilip Chand Raja S, Rajasekaran S, Sri Vijayanand KS, Shetty AP, Kanna RM, Thippeswamy PB
Eur Spine J 2021 Jun;30(6):1732-1743. Epub 2020 Sep 5 doi: 10.1007/s00586-020-06581-7. PMID: 32889553
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article
The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.
Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521

Clinical prediction guides

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.
Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132Free PMC Article
Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.
ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347
Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
A definition and clinical grading of Modic changes.
Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article

Recent systematic reviews

The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Neurotomy for the Treatment of Chronic Low Back Pain in Patients with Modic Changes: A Systematic Review.
Conger A, Schuster NM, Cheng DS, Sperry BP, Joshi AB, Haring RS, Duszynski B, McCormick ZL
Pain Med 2021 May 21;22(5):1039-1054. doi: 10.1093/pm/pnab040. PMID: 33544851
The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.
Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955
Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845Free PMC Article

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