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Invasive fungal infection

MedGen UID:
899732
•Concept ID:
C1262313
•
Disease or Syndrome
Synonyms: Disseminated Fungal Infection; Disseminated Fungal Infections; Fungal Infection, Disseminated; Fungal Infection, Invasive; Infection, Disseminated Fungal; Infection, Invasive Fungal; Invasive Fungal Infection; Invasive Fungal Infections; Invasive Mycoses; Mycoses, Invasive
SNOMED CT: Invasive fungal infection (12391000132109); Invasive mycosis (12391000132109); Invasive fungal disease (12391000132109)
 
HPO: HP:0020101

Definition

Fungal infection characterized by invasion of host tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive fungal infection

Professional guidelines

PubMed

Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).
Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Löhnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA
Ann Hematol 2018 Feb;97(2):197-207. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3196-2. PMID: 29218389Free PMC Article
Contemporary Strategies in the Prevention and Management of Fungal Infections.
Koehler P, Cornely OA
Infect Dis Clin North Am 2016 Mar;30(1):265-75. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.003. PMID: 26739606

Recent clinical studies

Etiology

Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study.
Puerta-Alcalde P, Monzó-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amargós J, Machado M, Martin-Davila P, Franch-Sarto M, Sánchez-Romero I, Badiola J, Gómez L, Ruiz-Camps I, Yáñez L, Vázquez L, Chumbita M, Marco F, Soriano A, González P, Fernández-Cruz A, Batlle M, Fortún J, Guinea J, Gudiol C, García J, Ruiz Pérez de Pipaón M, Alastruey-Izquierdo A, Garcia-Vidal C
J Infect 2023 Jul;87(1):46-53. Epub 2023 May 16 doi: 10.1016/j.jinf.2023.05.005. PMID: 37201859
Voriconazole-induced periostitis.
Fernández Ávila DC, Diehl M, Degrave AM, Buttazzoni M, Pereira T, Aguirre MA, Basquiera AL, Scolnik M
Reumatismo 2021 Apr 19;73(1):44-47. doi: 10.4081/reumatismo.2021.1368. PMID: 33874646
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.
Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M
Clin Infect Dis 2020 Feb 14;70(5):723-730. doi: 10.1093/cid/ciz282. PMID: 30958538Free PMC Article
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article

Diagnosis

Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study.
Puerta-Alcalde P, Monzó-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amargós J, Machado M, Martin-Davila P, Franch-Sarto M, Sánchez-Romero I, Badiola J, Gómez L, Ruiz-Camps I, Yáñez L, Vázquez L, Chumbita M, Marco F, Soriano A, González P, Fernández-Cruz A, Batlle M, Fortún J, Guinea J, Gudiol C, García J, Ruiz Pérez de Pipaón M, Alastruey-Izquierdo A, Garcia-Vidal C
J Infect 2023 Jul;87(1):46-53. Epub 2023 May 16 doi: 10.1016/j.jinf.2023.05.005. PMID: 37201859
Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Invasive Candidiasis.
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article

Therapy

Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients.
John J, Loo A, Mazur S, Walsh TJ
Expert Opin Drug Metab Toxicol 2019 Nov;15(11):881-895. Epub 2019 Oct 30 doi: 10.1080/17425255.2019.1671971. PMID: 31550939
Defining breakthrough invasive fungal infection-Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology.
Cornely OA, Hoenigl M, Lass-Flörl C, Chen SC, Kontoyiannis DP, Morrissey CO, Thompson GR 3rd; Mycoses Study Group Education and Research Consortium (MSG-ERC) and the European Confederation of Medical Mycology (ECMM)
Mycoses 2019 Sep;62(9):716-729. Epub 2019 Jul 19 doi: 10.1111/myc.12960. PMID: 31254420Free PMC Article
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Triazole antifungals: a review.
Peyton LR, Gallagher S, Hashemzadeh M
Drugs Today (Barc) 2015 Dec;51(12):705-18. doi: 10.1358/dot.2015.51.12.2421058. PMID: 26798851

Prognosis

Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients.
John J, Loo A, Mazur S, Walsh TJ
Expert Opin Drug Metab Toxicol 2019 Nov;15(11):881-895. Epub 2019 Oct 30 doi: 10.1080/17425255.2019.1671971. PMID: 31550939
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Invasive Aspergillosis in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article

Clinical prediction guides

Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.
Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M
Clin Infect Dis 2020 Feb 14;70(5):723-730. doi: 10.1093/cid/ciz282. PMID: 30958538Free PMC Article
Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients.
John J, Loo A, Mazur S, Walsh TJ
Expert Opin Drug Metab Toxicol 2019 Nov;15(11):881-895. Epub 2019 Oct 30 doi: 10.1080/17425255.2019.1671971. PMID: 31550939
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Cryptococcus: from environmental saprophyte to global pathogen.
May RC, Stone NR, Wiesner DL, Bicanic T, Nielsen K
Nat Rev Microbiol 2016 Feb;14(2):106-17. Epub 2015 Dec 21 doi: 10.1038/nrmicro.2015.6. PMID: 26685750Free PMC Article
Mucormycosis in India: unique features.
Chakrabarti A, Singh R
Mycoses 2014 Dec;57 Suppl 3:85-90. Epub 2014 Sep 3 doi: 10.1111/myc.12243. PMID: 25187095

Recent systematic reviews

Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer.
Uneno Y, Imura H, Makuuchi Y, Tochitani K, Watanabe N
Cochrane Database Syst Rev 2022 Nov 28;11(11):CD013604. doi: 10.1002/14651858.CD013604.pub2. PMID: 36440894Free PMC Article
Risk of infection in patients with hematological malignancies receiving CAR T-cell therapy: systematic review and meta-analysis.
Telli Dizman G, Aguado JM, Fernández-Ruiz M
Expert Rev Anti Infect Ther 2022 Nov;20(11):1455-1476. Epub 2022 Sep 28 doi: 10.1080/14787210.2022.2128762. PMID: 36148506
Invasive fungal infections in acute and chronic liver impairment: A systematic review.
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Post-COVID fungal infections of maxillofacial region: a systematic review.
Jain A, Taneja S
Oral Maxillofac Surg 2022 Sep;26(3):357-363. Epub 2021 Oct 7 doi: 10.1007/s10006-021-01010-5. PMID: 34622312Free PMC Article
Efficacy and safety of amphotericin B lipid-based formulations-A systematic review and meta-analysis.
Steimbach LM, Tonin FS, Virtuoso S, Borba HH, Sanches AC, Wiens A, Fernandez-Llimós F, Pontarolo R
Mycoses 2017 Mar;60(3):146-154. Epub 2016 Nov 22 doi: 10.1111/myc.12585. PMID: 27878878

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