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Feeling of lump in throat

MedGen UID:
9031
•Concept ID:
C0017650
•
Sign or Symptom
Synonyms: Globus Hystericus; Globus Pharyngeus; Globus Sensation; Globus Sensations; Sensation, Globus
SNOMED CT: Globus hystericus (267103008); Globus sensation (267103008); Globus pharyngeus (267103008); Feeling of lump in throat (267103008)

Definition

Persistent or intermittent non-painful sensation of a lump or foreign body in the throat occurring between meals in the absence of dysphagia, odynophagia, evidence of gastroesophageal acid reflux, or histopathogically based esophageal motility disorders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFeeling of lump in throat

Professional guidelines

PubMed

An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
The assessment and management of globus pharyngeus.
Siau R, Kinshuck A, Houghton L
Br J Hosp Med (Lond) 2021 Mar 2;82(3):1-8. Epub 2021 Mar 31 doi: 10.12968/hmed.2021.0038. PMID: 33792382
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
The development and validation of the laryngopharyngeal measure of perceived sensation.
Melancon CC, Russell GB, Ruckart K, Persia S, Peterson M, Carter Wright S Jr,, Madden LL
Laryngoscope 2020 Dec;130(12):2767-2772. Epub 2019 Oct 23 doi: 10.1002/lary.28348. PMID: 31643076
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703
Diabetes Mellitus: Management of Gastrointestinal Complications.
Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092
Nasolaryngoscopy.
Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

Diagnosis

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703
Functional disorders of swallowing.
Baumann A, Katz PO
Handb Clin Neurol 2016;139:483-488. doi: 10.1016/B978-0-12-801772-2.00039-4. PMID: 27719865
Nasolaryngoscopy.
Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

Therapy

An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
A lump in the throat: laryngopharyngeal reflux.
Hamilton NJI, Wilcock J, Hannan SA
BMJ 2020 Nov 2;371:m4091. doi: 10.1136/bmj.m4091. PMID: 33139245
Laryngeal Contact Ulcer.
Barrena BG, Miller TM, Nelson BL
Head Neck Pathol 2020 Dec;14(4):1032-1035. Epub 2020 May 7 doi: 10.1007/s12105-020-01167-7. PMID: 32383044Free PMC Article
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703
Diabetes Mellitus: Management of Gastrointestinal Complications.
Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

Prognosis

Validation of the Spanish version of DYsphagia in MUltiple Sclerosis questionnaire (DYMUS).
Renom M, Galán I, Vidal X, Aldevert M, Curto G, Feliu P, García I, Gonzalo L, Sibera X, Anglada E, Meza R, García M, Najas V, Mongay-Ochoa N, Arévalo MJ, Vidal-Jordana Á, Tintoré M, Bascuñana H, Montalban X, Terré R, Sastre-Garriga J
Mult Scler Relat Disord 2023 Jun;74:104724. Epub 2023 Apr 17 doi: 10.1016/j.msard.2023.104724. PMID: 37086636
Sensitivity, Specificity, and Predictive Values of Laryngopharyngeal Reflux Symptoms and Signs in Clinical Practice.
Lechien JR
Otolaryngol Head Neck Surg 2023 Jul;169(1):97-104. Epub 2023 Jan 29 doi: 10.1177/01945998221121822. PMID: 36040820
ESNM/ANMS Review. Diagnosis and management of globus sensation: A clinical challenge.
Zerbib F, Rommel N, Pandolfino J, Gyawali CP
Neurogastroenterol Motil 2020 Sep;32(9):e13850. Epub 2020 Apr 23 doi: 10.1111/nmo.13850. PMID: 32329203
Globus pharyngeus: a review of etiology, diagnostics, and treatment.
Järvenpää P, Arkkila P, Aaltonen LM
Eur Arch Otorhinolaryngol 2018 Aug;275(8):1945-1953. Epub 2018 Jun 25 doi: 10.1007/s00405-018-5041-1. PMID: 29943257
Diabetes Mellitus: Management of Gastrointestinal Complications.
Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

Clinical prediction guides

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
The development and validation of the laryngopharyngeal measure of perceived sensation.
Melancon CC, Russell GB, Ruckart K, Persia S, Peterson M, Carter Wright S Jr,, Madden LL
Laryngoscope 2020 Dec;130(12):2767-2772. Epub 2019 Oct 23 doi: 10.1002/lary.28348. PMID: 31643076
Gastric inlet patches: symptomatic or silent?
Cock C, Hamarneh Z
Curr Opin Otolaryngol Head Neck Surg 2019 Dec;27(6):453-462. doi: 10.1097/MOO.0000000000000581. PMID: 31567494
Clinical and psychological characteristics of patients with globus.
Bouchoucha M, Girault-Lidvan N, Hejnar M, Mary F, Airinei G, Benamouzig R
Clin Res Hepatol Gastroenterol 2019 Oct;43(5):614-622. Epub 2019 Feb 14 doi: 10.1016/j.clinre.2019.01.006. PMID: 30772327
Diabetes Mellitus: Management of Gastrointestinal Complications.
Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

Recent systematic reviews

Two-week-wait referrals in otolaryngology in a tertiary centre: cross-sectional study of benign outcomes, with a systematic review.
Mettias B, Charlton A, Ashokkumar S
J Laryngol Otol 2022 Nov;136(11):1051-1055. Epub 2021 Nov 3 doi: 10.1017/S0022215121003388. PMID: 34727998
Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans.
Roberts CA, Giesbrecht T, Fallon N, Thomas A, Mela DJ, Kirkham TC
J Nutr 2020 Jun 1;150(6):1619-1630. doi: 10.1093/jn/nxaa071. PMID: 32271923Free PMC Article
Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review.
Weijenborg PW, de Schepper HS, Smout AJ, Bredenoord AJ
Clin Gastroenterol Hepatol 2015 Feb;13(2):251-259.e1. Epub 2014 Jul 3 doi: 10.1016/j.cgh.2014.06.025. PMID: 24997325
Effects and side-effects of surgery for snoring and obstructive sleep apnea--a systematic review.
Franklin KA, Anttila H, Axelsson S, Gislason T, Maasilta P, Myhre KI, Rehnqvist N
Sleep 2009 Jan;32(1):27-36. PMID: 19189776Free PMC Article

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