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Modic type III vertebral endplate changes

MedGen UID:
904146
•Concept ID:
C4280775
•
Finding
Synonym: Modic type 3 vertebral endplate changes
 
HPO: HP:0030778

Definition

An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1 and T2-weighted sequences. Modic type III signals are thought to correspond to subchondral sclerosis seen on plain radiographs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModic type III vertebral endplate changes

Professional guidelines

PubMed

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.
Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

Recent clinical studies

Etiology

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.
Duan Y, Feng D, Zou K, Yang F, Chen R, Huang Y
World Neurosurg 2024 Mar 12;186:7-16. doi: 10.1016/j.wneu.2024.03.017. PMID: 38479643
Association between Modic changes and intervertebral vacuum phenomenon severity in patients undergoing percutaneous cement discoplasty.
Camino-Willhuber G, Kido G, Vildoza S, Martinez E, Tani S, Petracchi M, Gruenberg M, Sola C, Bendersky M
Acta Radiol 2023 Nov;64(11):2915-2921. Epub 2023 Aug 6 doi: 10.1177/02841851231191459. PMID: 37545178
Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.
Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article

Diagnosis

Role of growth plate (apophyseal ring fracture) in causing modic type changes in pediatric low back pain patients.
Manabe H, Sakai T, Omichi Y, Sugiura K, Morimoto M, Tezuka F, Yamashita K, Takata Y, Maeda T, Sairyo K
Eur Spine J 2021 Sep;30(9):2565-2569. Epub 2021 May 26 doi: 10.1007/s00586-021-06885-2. PMID: 34037865
Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).
Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ
Int J Mol Sci 2020 May 27;21(11) doi: 10.3390/ijms21113791. PMID: 32471173Free PMC Article
The influence of spinal-pelvic parameters on the prevalence of endplate Modic changes in degenerative thoracolumbar/lumbar kyphosis patients.
Xia W, Liu C, Duan S, Xu S, Wang K, Zhu Z, Liu H
PLoS One 2018;13(5):e0197470. Epub 2018 May 15 doi: 10.1371/journal.pone.0197470. PMID: 29763470Free PMC Article
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article
Modic changes in vertebral endplates: a comparison of MR imaging and multislice CT.
Kuisma M, Karppinen J, Haapea M, Lammentausta E, Niinimäki J, Tervonen O
Skeletal Radiol 2009 Feb;38(2):141-7. Epub 2008 Sep 20 doi: 10.1007/s00256-008-0590-9. PMID: 18807028

Therapy

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Frequency and characteristics of bacterial and viral low-grade infections of the intervertebral discs: a prospective, observational study.
Senker W, Aspalter S, Radl C, Pichler J, Doppler S, Weis S, Webersinke C, Wagner H, Hermann P, Aichholzer M, Aufschnaiter-Hießböck K, Thomae W, Stroh N, Hauser T, Gruber A
J Orthop Traumatol 2022 Mar 18;23(1):15. doi: 10.1186/s10195-022-00633-y. PMID: 35303173Free PMC Article
Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study.
Bråten LCH, Schistad EI, Espeland A, Kristoffersen PM, Haugen AJ, Marchand GH, Vetti N, Pripp AH, Kadar TI, Skouen JS, Grotle M, Grøvle L, Zwart JA, Brox JI, Storheim K; AIM-study group
BMC Musculoskelet Disord 2020 Jun 10;21(1):368. doi: 10.1186/s12891-020-03381-4. PMID: 32522268Free PMC Article
Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.
Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816
Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China.
Han C, Kuang MJ, Ma JX, Ma XL
Sci Rep 2017 Apr 12;7:46341. doi: 10.1038/srep46341. PMID: 28402320Free PMC Article

Prognosis

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
Distribution of Modic changes in patients with low back pain and its related factors.
Chen Y, Bao J, Yan Q, Wu C, Yang H, Zou J
Eur J Med Res 2019 Oct 9;24(1):34. doi: 10.1186/s40001-019-0393-6. PMID: 31597571Free PMC Article
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article
Hybrid Bone Single Photon Emission Computed Tomography Imaging in Evaluation of Chronic Low Back Pain: Correlation with Modic Changes and Degenerative Disc Disease.
Russo VM, Dhawan RT, Dharmarajah N, Baudracco I, Lazzarino AI, Casey AT
World Neurosurg 2017 Aug;104:816-823. Epub 2017 Apr 2 doi: 10.1016/j.wneu.2017.03.107. PMID: 28377243

Clinical prediction guides

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.
Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481
Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.
Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932
Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.
Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816
Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.
Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576Free PMC Article
Modic type III lesions and Schmorl's nodes are the same pathological changes?
Zhao JG, Zhang P, Zhang SF, Qi F, Huang WJ, Xia YZ, Li HM, Jing CW
Med Hypotheses 2010 Mar;74(3):524-6. Epub 2009 Oct 28 doi: 10.1016/j.mehy.2009.09.049. PMID: 19864075

Recent systematic reviews

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.
Duan Y, Feng D, Zou K, Yang F, Chen R, Huang Y
World Neurosurg 2024 Mar 12;186:7-16. doi: 10.1016/j.wneu.2024.03.017. PMID: 38479643

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