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Animal protein allergy

MedGen UID:
904400
•Concept ID:
C4082933
•
Pathologic Function
Synonyms: Allergy to animal; Allergy to animal protein; Allergy to animal proteins; Animal allergy; Animal Allergy; IgE-mediated animal protein allergy; Immunoglobulin E-mediated animal protein allergy
SNOMED CT: Allergy to animal protein (717234006); Allergy to animal (717234006); Animal allergy (717234006)
 
HPO: HP:0410320

Definition

Hypersensitivity in form of an adverse immune reaction against animal proteins. [from HPO]

Professional guidelines

PubMed

Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.
Commins SP
Expert Rev Clin Immunol 2020 Jul;16(7):667-677. Epub 2020 Jul 8 doi: 10.1080/1744666X.2020.1782745. PMID: 32571129Free PMC Article
Diagnosis and Management of Patients with the α-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM
J Allergy Clin Immunol Pract 2020 Jan;8(1):15-23.e1. Epub 2019 Sep 28 doi: 10.1016/j.jaip.2019.09.017. PMID: 31568928Free PMC Article

Recent clinical studies

Etiology

Clinical Relevance of Cross-Reactivity in Food Allergy.
Cox AL, Eigenmann PA, Sicherer SH
J Allergy Clin Immunol Pract 2021 Jan;9(1):82-99. doi: 10.1016/j.jaip.2020.09.030. PMID: 33429724
Diagnosis and Management of Patients with the α-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM
J Allergy Clin Immunol Pract 2020 Jan;8(1):15-23.e1. Epub 2019 Sep 28 doi: 10.1016/j.jaip.2019.09.017. PMID: 31568928Free PMC Article
EAACI Molecular Allergology User's Guide.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, EIgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M
Pediatr Allergy Immunol 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833
Food allergies: the basics.
Valenta R, Hochwallner H, Linhart B, Pahr S
Gastroenterology 2015 May;148(6):1120-31.e4. Epub 2015 Feb 11 doi: 10.1053/j.gastro.2015.02.006. PMID: 25680669Free PMC Article
Review article: the diagnosis and management of food allergy and food intolerances.
Turnbull JL, Adams HN, Gorard DA
Aliment Pharmacol Ther 2015 Jan;41(1):3-25. Epub 2014 Oct 14 doi: 10.1111/apt.12984. PMID: 25316115

Diagnosis

Food allergy and hypersensitivity reactions in children and adults-A review.
Tedner SG, Asarnoj A, Thulin H, Westman M, Konradsen JR, Nilsson C
J Intern Med 2022 Mar;291(3):283-302. Epub 2021 Dec 22 doi: 10.1111/joim.13422. PMID: 34875122
Clinical Relevance of Cross-Reactivity in Food Allergy.
Cox AL, Eigenmann PA, Sicherer SH
J Allergy Clin Immunol Pract 2021 Jan;9(1):82-99. doi: 10.1016/j.jaip.2020.09.030. PMID: 33429724
Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Egg Allergy: Diagnosis and Immunotherapy.
Dona DW, Suphioglu C
Int J Mol Sci 2020 Jul 16;21(14) doi: 10.3390/ijms21145010. PMID: 32708567Free PMC Article
Food allergy: immune mechanisms, diagnosis and immunotherapy.
Yu W, Freeland DMH, Nadeau KC
Nat Rev Immunol 2016 Dec;16(12):751-765. Epub 2016 Oct 31 doi: 10.1038/nri.2016.111. PMID: 27795547Free PMC Article

Therapy

Cow's Milk Protein Allergy as a Model of Food Allergies.
Giannetti A, Toschi Vespasiani G, Ricci G, Miniaci A, di Palmo E, Pession A
Nutrients 2021 Apr 30;13(5) doi: 10.3390/nu13051525. PMID: 33946553Free PMC Article
Home Environmental Interventions for House Dust Mite.
Wilson JM, Platts-Mills TAE
J Allergy Clin Immunol Pract 2018 Jan-Feb;6(1):1-7. doi: 10.1016/j.jaip.2017.10.003. PMID: 29310755Free PMC Article
Food allergy: immune mechanisms, diagnosis and immunotherapy.
Yu W, Freeland DMH, Nadeau KC
Nat Rev Immunol 2016 Dec;16(12):751-765. Epub 2016 Oct 31 doi: 10.1038/nri.2016.111. PMID: 27795547Free PMC Article
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Food allergies: the basics.
Valenta R, Hochwallner H, Linhart B, Pahr S
Gastroenterology 2015 May;148(6):1120-31.e4. Epub 2015 Feb 11 doi: 10.1053/j.gastro.2015.02.006. PMID: 25680669Free PMC Article

Prognosis

Diagnosis and Management of Patients with the α-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM
J Allergy Clin Immunol Pract 2020 Jan;8(1):15-23.e1. Epub 2019 Sep 28 doi: 10.1016/j.jaip.2019.09.017. PMID: 31568928Free PMC Article
Immune pathomechanism and classification of drug hypersensitivity.
Pichler WJ
Allergy 2019 Aug;74(8):1457-1471. Epub 2019 Apr 29 doi: 10.1111/all.13765. PMID: 30843233
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Food allergies: the basics.
Valenta R, Hochwallner H, Linhart B, Pahr S
Gastroenterology 2015 May;148(6):1120-31.e4. Epub 2015 Feb 11 doi: 10.1053/j.gastro.2015.02.006. PMID: 25680669Free PMC Article
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351

Clinical prediction guides

Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis.
Zuberbier T, Wood RA, Bindslev-Jensen C, Fiocchi A, Chinthrajah RS, Worm M, Deschildre A, Fernandez-Rivas M, Santos AF, Jaumont X, Tassinari P
J Allergy Clin Immunol Pract 2023 Apr;11(4):1134-1146. Epub 2022 Dec 15 doi: 10.1016/j.jaip.2022.11.036. PMID: 36529441
Diagnosis and Management of Patients with the α-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM
J Allergy Clin Immunol Pract 2020 Jan;8(1):15-23.e1. Epub 2019 Sep 28 doi: 10.1016/j.jaip.2019.09.017. PMID: 31568928Free PMC Article
Immune pathomechanism and classification of drug hypersensitivity.
Pichler WJ
Allergy 2019 Aug;74(8):1457-1471. Epub 2019 Apr 29 doi: 10.1111/all.13765. PMID: 30843233
Food allergies: the basics.
Valenta R, Hochwallner H, Linhart B, Pahr S
Gastroenterology 2015 May;148(6):1120-31.e4. Epub 2015 Feb 11 doi: 10.1053/j.gastro.2015.02.006. PMID: 25680669Free PMC Article
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351

Recent systematic reviews

Systematic review and meta-analyses on the accuracy of diagnostic tests for IgE-mediated food allergy.
Riggioni C, Ricci C, Moya B, Wong D, van Goor E, Bartha I, Buyuktiryaki B, Giovannini M, Jayasinghe S, Jaumdally H, Marques-Mejias A, Piletta-Zanin A, Berbenyuk A, Andreeva M, Levina D, Iakovleva E, Roberts G, Chu D, Peters R, du Toit G, Skypala I, Santos AF
Allergy 2024 Feb;79(2):324-352. Epub 2023 Nov 27 doi: 10.1111/all.15939. PMID: 38009299
Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis.
Zuberbier T, Wood RA, Bindslev-Jensen C, Fiocchi A, Chinthrajah RS, Worm M, Deschildre A, Fernandez-Rivas M, Santos AF, Jaumont X, Tassinari P
J Allergy Clin Immunol Pract 2023 Apr;11(4):1134-1146. Epub 2022 Dec 15 doi: 10.1016/j.jaip.2022.11.036. PMID: 36529441
Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis.
de Silva D, Rodríguez Del Río P, de Jong NW, Khaleva E, Singh C, Nowak-Wegrzyn A, Muraro A, Begin P, Pajno G, Fiocchi A, Sanchez A, Jones C, Nilsson C, Bindslev-Jensen C, Wong G, Sampson H, Beyer K, Marchisotto MJ, Fernandez Rivas M, Meyer R, Lau S, Nurmatov U, Roberts G; GA2LEN Food Allergy Guidelines Group
Allergy 2022 Jun;77(6):1852-1862. Epub 2022 Jan 19 doi: 10.1111/all.15211. PMID: 35001400Free PMC Article
Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials.
de Silva D, Halken S, Singh C, Muraro A, Angier E, Arasi S, Arshad H, Beyer K, Boyle R, du Toit G, Eigenmann P, Grimshaw K, Hoest A, Jones C, Khaleva E, Lack G, Szajewska H, Venter C, Verhasselt V, Roberts G; European Academy of Allergy, Clinical Immunology Food Allergy, Anaphylaxis Guidelines Group
Pediatr Allergy Immunol 2020 Oct;31(7):813-826. Epub 2020 Jun 18 doi: 10.1111/pai.13273. PMID: 32396244
Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis.
Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos AF, van Ree R, Timmermans F, Sheikh A
Allergy 2017 Aug;72(8):1133-1147. Epub 2017 May 11 doi: 10.1111/all.13124. PMID: 28058751

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