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Reduced antithrombin antigen

MedGen UID:
906331
•Concept ID:
C4280702
•
Finding
HPO: HP:0040246

Definition

Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced antithrombin antigen

Professional guidelines

PubMed

Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure.
Yao Y, Li Y, Jin Q, Li X, Zhang X, Lv Q
Cardiovasc Ther 2024;2024:4405152. Epub 2024 Mar 12 doi: 10.1155/2024/4405152. PMID: 38505191Free PMC Article
HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol 2017 Nov;63:69-90. Epub 2017 Jan 23 doi: 10.1016/j.matbio.2017.01.003. PMID: 28126521Free PMC Article
Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults.
Johansson JO, Landin K, Johannsson G, Tengborn L, Bengtsson BA
Thromb Haemost 1996 Sep;76(3):422-8. PMID: 8883281

Recent clinical studies

Etiology

Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.
Natorska J, Corral J, de la Morena-Barrio ME, Bravo-Pérez C, Bagoly Z, Bereczky Z, Treliński J, Witkowski M, Klajmon A, Undas A, Ząbczyk M
Thromb Haemost 2023 Sep;123(9):880-891. Epub 2023 May 18 doi: 10.1055/s-0043-1768712. PMID: 37201530Free PMC Article
Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-κB pathway.
Yu YH, Zhang HJ, Yang F, Xu L, Liu H
J Ethnopharmacol 2023 Jun 28;310:116311. Epub 2023 Mar 7 doi: 10.1016/j.jep.2023.116311. PMID: 36894110
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326

Diagnosis

Correlation of Antithrombin Functional Status and Levels with Liver Fibrosis in Patients with Hepatitis C.
Saboor M, Khan A, Hamali HA, Mobarki AA, Madkhali AM, Dobie G, Nizamani GS
Clin Lab 2022 Feb 1;68(2) doi: 10.7754/Clin.Lab.2021.210608. PMID: 35142192
Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia.
Lu Y, Villoutreix BO, Biswas I, Ding Q, Wang X, Rezaie AR
Thromb Haemost 2022 May;122(5):679-691. Epub 2021 Sep 5 doi: 10.1055/a-1549-6407. [Epub ahead of print] PMID: 34256393Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326

Therapy

Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.
Christersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A
Heart 2019 Feb;105(3):235-242. Epub 2018 Sep 12 doi: 10.1136/heartjnl-2018-313351. PMID: 30209126Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Microvascular prothrombogenicity and transplant coronary artery disease.
Labarrere CA, Deng MC
Transpl Immunol 2002 May;9(2-4):243-9. doi: 10.1016/s0966-3274(02)00025-4. PMID: 12180838

Prognosis

Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-κB pathway.
Yu YH, Zhang HJ, Yang F, Xu L, Liu H
J Ethnopharmacol 2023 Jun 28;310:116311. Epub 2023 Mar 7 doi: 10.1016/j.jep.2023.116311. PMID: 36894110
Antithrombin p.Thr147Ala: The First Founder Mutation in People of African Origin Responsible for Inherited Antithrombin Deficiency.
Orlando C, de la Morena-Barrio B, Pareyn I, Vanhoorelbeke K, Martínez-Martínez I, Vicente V, Corral J, Jochmans K, de la Morena-Barrio ME
Thromb Haemost 2021 Feb;121(2):182-191. Epub 2020 Sep 13 doi: 10.1055/s-0040-1716531. PMID: 32920809
Antithrombin and fibrinogen levels as predictors for plasma L-asparaginase activity in children with acute lymphoblastic leukemia.
Merlen C, Bonnefoy A, Afeich C, Théorêt Y, Laverdière C, Leclerc JM, Rivard GE
Pediatr Blood Cancer 2019 Jul;66(7):e27729. Epub 2019 Apr 2 doi: 10.1002/pbc.27729. PMID: 30938058
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Changes in von Willebrand factor and ADAMTS-13 in patients following arthroplasty.
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054

Clinical prediction guides

Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-κB pathway.
Yu YH, Zhang HJ, Yang F, Xu L, Liu H
J Ethnopharmacol 2023 Jun 28;310:116311. Epub 2023 Mar 7 doi: 10.1016/j.jep.2023.116311. PMID: 36894110
Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326
Neonatal antithrombin III.
Peters M, Jansen E, ten Cate JW, Kahlé LH, Ockelford P, Breederveld C
Br J Haematol 1984 Dec;58(4):579-87. doi: 10.1111/j.1365-2141.1984.tb06104.x. PMID: 6518134

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