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Modic type II vertebral endplate changes

MedGen UID:: 906838
•Concept ID:: C4280776
•: Finding

Synonym:	Modic type 2 vertebral endplate changes

HPO:	HP:0030777

Definition

An abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVModic type II vertebral endplate changes

Abnormality of the skeletal system
- Abnormal skeletal morphology
  - Abnormal axial skeleton morphology
    - Abnormality of the vertebral column
      - Abnormal vertebral morphology
        Modic type vertebral endplate changes
        Modic type II vertebral endplate changes

Professional guidelines

PubMed

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.

Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

See all (1)

Recent clinical studies

Etiology

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.

Duan Y, Feng D, Zou K, Yang F, Chen R, Huang Y
World Neurosurg 2024 Mar 12;186:7-16. doi: 10.1016/j.wneu.2024.03.017. PMID: 38479643

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.

ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.

Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.

Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

See all (29)

Diagnosis

Role of growth plate (apophyseal ring fracture) in causing modic type changes in pediatric low back pain patients.

Manabe H, Sakai T, Omichi Y, Sugiura K, Morimoto M, Tezuka F, Yamashita K, Takata Y, Maeda T, Sairyo K
Eur Spine J 2021 Sep;30(9):2565-2569. Epub 2021 May 26 doi: 10.1007/s00586-021-06885-2. PMID: 34037865

Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.

Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576 Free PMC Article

Refined Phenotyping of Modic Changes: Imaging Biomarkers of Prolonged Severe Low Back Pain and Disability.

Määttä JH, Karppinen J, Paananen M, Bow C, Luk KDK, Cheung KMC, Samartzis D
Medicine (Baltimore) 2016 May;95(22):e3495. doi: 10.1097/MD.0000000000003495. PMID: 27258491 Free PMC Article

Type II Modic Changes May not Always Represent Fat Degeneration: A Study Using MR Fat Suppression Sequence.

Feng Z, Liu Y, Wei W, Hu S, Wang Y
Spine (Phila Pa 1976) 2016 Aug 15;41(16):E987-E994. doi: 10.1097/BRS.0000000000001526. PMID: 26909837

Modic changes in vertebral endplates: a comparison of MR imaging and multislice CT.

Kuisma M, Karppinen J, Haapea M, Lammentausta E, Niinimäki J, Tervonen O
Skeletal Radiol 2009 Feb;38(2):141-7. Epub 2008 Sep 20 doi: 10.1007/s00256-008-0590-9. PMID: 18807028

See all (12)

Therapy

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study).

Bråten LCH, Grøvle L, Espeland A, Pripp AH, Grotle M, Helllum C, Haugen AJ, Froholdt A, Rolfsen MP, Nygaard ØP, Lutro O, Kristoffersen PM, Anke A, Schistad EI, Skouen JS, Brox JI, Zwart JA, Storheim K; AIM-study group
BMC Musculoskelet Disord 2020 Jul 13;21(1):458. doi: 10.1186/s12891-020-03422-y. PMID: 32660517 Free PMC Article

Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.

Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816

Modic Changes in the Lumbar Spine are Common Aging-related Degenerative Findings that Parallel With Disk Degeneration.

Chen L, Hu X, Zhang J, Battié MC, Lin X, Wang Y
Clin Spine Surg 2018 Aug;31(7):312-317. doi: 10.1097/BSD.0000000000000662. PMID: 29847414

Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China.

Han C, Kuang MJ, Ma JX, Ma XL
Sci Rep 2017 Apr 12;7:46341. doi: 10.1038/srep46341. PMID: 28402320 Free PMC Article

See all (8)

Prognosis

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.

Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932

Distribution of Modic changes in patients with low back pain and its related factors.

Chen Y, Bao J, Yan Q, Wu C, Yang H, Zou J
Eur J Med Res 2019 Oct 9;24(1):34. doi: 10.1186/s40001-019-0393-6. PMID: 31597571 Free PMC Article

Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.

Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576 Free PMC Article

The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.

Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955

See all (10)

Clinical prediction guides

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.

ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.

Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932

Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.

Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816

Modic changes in the cervical endplate of patients suffering from cervical spondylotic myelopathy.

Qiao P, Xu TT, Zhang W, Tian R
J Orthop Surg Res 2018 Apr 18;13(1):90. doi: 10.1186/s13018-018-0805-2. PMID: 29669576 Free PMC Article

See all (20)