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Polychromasia

MedGen UID:
90731
•Concept ID:
C0333942
•
Finding
Synonyms: Polychromasia on peripheral blood smear; Polychromatophilia; Polychromatophilic stain reaction; Polychromatosis; Polychromophilia
SNOMED CT: Polychromatophilic stain reaction (52300009); Polychromatophilia (52300009); Polychromophilia (52300009); Polychromatosis (52300009); Polychromasia (52300009)
 
HPO: HP:0034609

Definition

Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolychromasia

Recent clinical studies

Etiology

Neonatal Reference Intervals for the Complete Blood Count Parameters MicroR and HYPO-He: Sensitivity Beyond the Red Cell Indices for Identifying Microcytic and Hypochromic Disorders.
Bahr TM, Christensen TR, Henry E, Wilkes J, Ohls RK, Bennett ST, Ward DM, Pysher TJ, Christensen RD
J Pediatr 2021 Dec;239:95-100.e2. Epub 2021 Aug 10 doi: 10.1016/j.jpeds.2021.08.002. PMID: 34389321Free PMC Article
E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures.
Nobre RJ, Herráez-Hernández E, Fei JW, Langbein L, Kaden S, Gröne HJ, de Villiers EM
J Virol 2009 Apr;83(7):2907-16. Epub 2009 Jan 19 doi: 10.1128/JVI.02490-08. PMID: 19153227Free PMC Article
New approach to human high-risk papillomavirus (HR-HPV) genotyping.
Weismanová E, Weismann P, Vizváryová M, Lehotská V, Krizanová O, Repiská V, Kausitz J
Neoplasma 2002;49(4):217-24. PMID: 12382018
Abnormal features of peripheral blood films from Gambian children with malaria.
Facer CA, Jenkins GC
Ann Trop Paediatr 1989 Jun;9(2):107-10. doi: 10.1080/02724936.1989.11748608. PMID: 2473697
Relationship of reticulocyte age to polychromasia, shift cells, and shift reticulocytes.
Crouch JY, Kaplow LS
Arch Pathol Lab Med 1985 Apr;109(4):325-9. PMID: 2580503

Diagnosis

Unstable hemoglobin Montreal II uncovered in an adult with unexplained hemolysis exacerbated by a presumed viral infection: a case report.
Medri C, Méndez A, Hammerer-Lercher A, Rovó A, Angelillo-Scherrer A
J Med Case Rep 2022 Apr 10;16(1):145. doi: 10.1186/s13256-022-03374-y. PMID: 35397565Free PMC Article
Inception and Development of the Papanicolaou Stain Method.
Chantziantoniou N, Donnelly AD, Mukherjee M, Boon ME, Austin RM
Acta Cytol 2017;61(4-5):266-280. Epub 2017 Apr 7 doi: 10.1159/000457827. PMID: 28384641
Hemolytic anemia due to warm autoantibodies.
Packman CH
Blood Rev 2008 Jan;22(1):17-31. Epub 2007 Sep 27 doi: 10.1016/j.blre.2007.08.001. PMID: 17904259
Hemoglobin S/O(Arab): thirteen new cases and review of the literature.
Zimmerman SA, O'Branski EE, Rosse WF, Ware RE
Am J Hematol 1999 Apr;60(4):279-84. doi: 10.1002/(sici)1096-8652(199904)60:4<279::aid-ajh5>3.0.co;2-2. PMID: 10203101
Beta-thalassemia/haemoglobin E disease in Vietnam.
Nguyen CK, Le TT, Duong BT, Dinh PH, Ta TH, Tran HH
J Trop Pediatr 1990 Feb;36(1):43-5. doi: 10.1093/tropej/36.1.43. PMID: 2313782

Therapy

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin.
Ong V, Hough G, Schlosser M, Bartizal K, Balkovec JM, James KD, Krishnan BR
Antimicrob Agents Chemother 2016 Nov;60(11):6872-6879. Epub 2016 Oct 21 doi: 10.1128/AAC.00701-16. PMID: 27620474Free PMC Article
Intravenous immunoglobulin-induced hemolytic anemia in a patient with juvenile dermatomyositis.
Clemenz MR, McGowan Iv JW, Shuler MJ, Lynn AW
J Drugs Dermatol 2013 Jan;12(1):111-3. PMID: 23377338
Diagnostic cytological features of polyacrylamide gel injection augmentation mammoplasty.
Lau PP, Chan AC, Tsui MH
Pathology 2009;41(5):443-7. doi: 10.1080/00313020903041168. PMID: 19900083
Oxcarbazepine-induced hemolytic anemia in a geriatric patient.
Chaudhry MM, Abrar M, Mutahir K, Mendoza C
Am J Ther 2008 Mar-Apr;15(2):187-9. doi: 10.1097/MJT.0b013e31815afb6f. PMID: 18356642
Hemolytic anemia due to warm autoantibodies.
Packman CH
Blood Rev 2008 Jan;22(1):17-31. Epub 2007 Sep 27 doi: 10.1016/j.blre.2007.08.001. PMID: 17904259

Prognosis

Unique case of thrombotic thrombocytopenic purpura and diabetes insipidus.
Qureshi M, Pathak N, Pinsker RW, Gintautas J, Santucci T Jr
Proc West Pharmacol Soc 2005;48:145-7. PMID: 16416683
Pattern of some haematological indices in newly diagnosed pulmonary tuberculosis cases in Iwo, Nigeria: diagnostic and therapeutic implications.
Dosumu EA
Niger J Med 2001 Jan-Mar;10(1):18-20. PMID: 11705048
Gaucher disease type I: analysis of two cases with thalassemic facies and pulmonary arteriovenous fistulas.
Gürakan F, Koçak N, Yüce A, Ozen H
Turk J Pediatr 2001 Jul-Sep;43(3):237-42. PMID: 11592516
Microangiopathic hemolytic anemia as an initial presentation of metastatic cancer of unknown primary origin.
Lin YC, Chang HK, Sun CF, Shih LY
South Med J 1995 Jun;88(6):683-7. doi: 10.1097/00007611-199506000-00021. PMID: 7777893

Clinical prediction guides

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin.
Ong V, Hough G, Schlosser M, Bartizal K, Balkovec JM, James KD, Krishnan BR
Antimicrob Agents Chemother 2016 Nov;60(11):6872-6879. Epub 2016 Oct 21 doi: 10.1128/AAC.00701-16. PMID: 27620474Free PMC Article
Triosephosphate isomerase deficiency with elevated sweat chloride test: report of a case.
Yenicesu I, Kalayci O, Semizel E, Kavak U, Gümrük F, Ferec C, Beutler E
Turk J Pediatr 2000 Oct-Dec;42(4):319-21. PMID: 11196750
A diversity of blood smear examination system of Thai public hospital.
Vattanaviboon P, Manochiopinij S, Sirisali K, Tankeyul B
Southeast Asian J Trop Med Public Health 1999;30 Suppl 3:57-61. PMID: 10926261
Beta-thalassemia/haemoglobin E disease in Vietnam.
Nguyen CK, Le TT, Duong BT, Dinh PH, Ta TH, Tran HH
J Trop Pediatr 1990 Feb;36(1):43-5. doi: 10.1093/tropej/36.1.43. PMID: 2313782
Beta 0-thalassemia due to a nonsense mutation at beta 90 (GAG----TAG) in human hemoglobin gene.
Nomura Y, Nanjo K, Miyamura K, Harano T, Harano K, Ueda S
Jpn J Med 1990 Jan-Feb;29(1):2-6. doi: 10.2169/internalmedicine1962.29.2. PMID: 2214342

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