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Adenocarcinoma in Multiple Adenomatous Polyps

MedGen UID:
90757
•Concept ID:
C0334295
•
Neoplastic Process
Synonym: Adenocarcinoma in multiple adenomatous polyps
SNOMED CT: Adenocarcinoma in multiple adenomatous polyps (47299001)

Definition

Adenocarcinomas developing in gastrointestinal tract adenomas in patients with multiple adenomatous polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in Multiple Adenomatous Polyps

Professional guidelines

PubMed

Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experience.
Jaganmohan S, Lynch PM, Raju RP, Ross WA, Lee JE, Raju GS, Bhutani MS, Fleming JB, Lee JH
Dig Dis Sci 2012 Mar;57(3):732-7. Epub 2011 Sep 30 doi: 10.1007/s10620-011-1917-2. PMID: 21960285
Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients.
Ito Y, Miyauchi A, Ishikawa H, Hirokawa M, Kudo T, Tomoda C, Miya A
Endocr J 2011;58(8):685-9. Epub 2011 Jun 14 doi: 10.1507/endocrj.ej11-0022. PMID: 21670544
Nonampullary duodenal polyps: characteristics and endoscopic management.
Abbass R, Rigaux J, Al-Kawas FH
Gastrointest Endosc 2010 Apr;71(4):754-9. doi: 10.1016/j.gie.2009.11.043. PMID: 20363416

Recent clinical studies

Etiology

Histomorphological analysis of gastric polyps.
Amarapurkar AD, Kale KM, Naik LP, Shukla AP
Indian J Pathol Microbiol 2021 Jun;64(Supplement):S69-S72. doi: 10.4103/IJPM.IJPM_118_20. PMID: 34135141
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Familial polyposis.
DeCosse JJ, Adams MB, Condon RE
Cancer 1977 Jan;39(1):267-73. doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x. PMID: 832240
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Diagnosis

Attenuated Familial Adenomatous Polyposis.
Eizuka M, Toya Y, Kosaka T, Oizumi T, Morishita T, Kasugai S, Yanai S, Sugai T, Matsumoto T
Intern Med 2023 Sep 15;62(18):2651-2654. Epub 2023 Feb 1 doi: 10.2169/internalmedicine.1101-22. PMID: 36725040Free PMC Article
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Familial polyposis.
DeCosse JJ, Adams MB, Condon RE
Cancer 1977 Jan;39(1):267-73. doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x. PMID: 832240
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Therapy

Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Adenocarcinoma after ileoanal anastomosis for familial adenomatous polyposis: review of risk factors and current surveillance apropos of a case.
Campos FG, Habr-Gama A, Kiss DR, da Silva EV, Rawet V, Imperiale AR, Perez R, da Silva JH, Sousa AH Jr, Gama-Rodrigues J
J Gastrointest Surg 2005 May-Jun;9(5):695-702. doi: 10.1016/j.gassur.2004.10.017. PMID: 15862266
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

Prognosis

The prognostic and clinicopathological roles of microsatellite instability, PD-L1 expression and tumor-infiltrating leukocytes in familial adenomatous polyposis.
Ma SM, Dong J, Liang L, Liu XT, Meng XY, Zhang HS, Yang J
Eur J Surg Oncol 2022 Jan;48(1):211-217. Epub 2021 Aug 29 doi: 10.1016/j.ejso.2021.08.032. PMID: 34483031
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article

Clinical prediction guides

From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy.
Russo E, Gloria LD, Nannini G, Meoni G, Niccolai E, Ringressi MN, Baldi S, Fani R, Tenori L, Taddei A, Ramazzotti M, Amedei A
Neoplasia 2023 Jun;40:100901. Epub 2023 Apr 12 doi: 10.1016/j.neo.2023.100901. PMID: 37058886Free PMC Article
Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas.
Lo CH, Wu DC, Jao SW, Wu CC, Lin CY, Chuang CH, Lin YB, Chen CH, Chen YT, Chen JH, Hsiao KH, Chen YJ, Chen YT, Wang JY, Li LH
J Biomed Sci 2022 Oct 27;29(1):88. doi: 10.1186/s12929-022-00869-0. PMID: 36303164Free PMC Article
Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study.
Iwamuro M, Kusumoto C, Nakagawa M, Matsueda K, Kobayashi S, Yoshioka M, Inaba T, Toyokawa T, Sakaguchi C, Tanaka S, Tanaka T, Okada H
BMC Gastroenterol 2022 Jun 12;22(1):294. doi: 10.1186/s12876-022-02368-w. PMID: 35692036Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

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