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Adrenal Cortical Glomerulosa Cell Adenoma

MedGen UID:: 90765
•Concept ID:: C0334335
•: Neoplastic Process

Synonyms:	Adrenal Cortex Glomerulosa Cell Adenoma; Adrenal cortical adenoma - glomerulosa cell; Adrenal cortical adenoma, glomerulosa cell; Adrenal Gland Glomerulosa Cell Adenoma; Glomerulosa Cell Adrenal Cortex Adenoma; Glomerulosa Cell Adrenal Cortical Adenoma; Glomerulosa Cell Adrenocortical Adenoma
SNOMED CT:	Adrenal cortical adenoma - glomerulosa cell (19329008); Adrenal cortical adenoma, glomerulosa cell (19329008)

Definition

An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdrenal Cortical Glomerulosa Cell Adenoma

Benign neoplasm
- Benign Peritoneal and Retroperitoneal Neoplasm
  - Benign Retroperitoneal Neoplasm
    - Benign neoplasm of adrenal gland
      - Benign Adrenal Cortical Neoplasm
        Adrenocortical adenoma
        Adrenal Cortical Glomerulosa Cell Adenoma

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.

Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608 Free PMC Article

Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.

Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H
J Steroid Biochem Mol Biol 2022 Jul;221:106116. Epub 2022 May 6 doi: 10.1016/j.jsbmb.2022.106116. PMID: 35533918

Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.

Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ
J Clin Endocrinol Metab 2012 May;97(5):E819-29. Epub 2012 Mar 22 doi: 10.1210/jc.2011-2965. PMID: 22442279

See all (4)

Recent clinical studies

Etiology

Disordered CYP11B2 Expression in Primary Aldosteronism.

Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA
Horm Metab Res 2017 Dec;49(12):957-962. Epub 2017 Dec 4 doi: 10.1055/s-0043-122238. PMID: 29202495

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.

Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K
Mol Cell Endocrinol 2017 Feb 5;441:124-133. Epub 2016 Oct 14 doi: 10.1016/j.mce.2016.10.014. PMID: 27751767 Free PMC Article

KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling.

Boulkroun S, Golib Dzib JF, Samson-Couterie B, Rosa FL, Rickard AJ, Meatchi T, Amar L, Benecke A, Zennaro MC
Mol Cell Endocrinol 2013 May 22;371(1-2):221-7. Epub 2013 Jan 30 doi: 10.1016/j.mce.2013.01.018. PMID: 23376008

Primary aldosteronism.

Gordon RD
J Endocrinol Invest 1995 Jul-Aug;18(7):495-511. doi: 10.1007/BF03349761. PMID: 9221268

Mineralocorticoid production of adrenal cortical adenomas.

Gláz E, Rácz K, Varga I, Kiss R, Tóth M, Fütö L
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):57-64. doi: 10.1016/0960-0760(93)90122-d. PMID: 8481352

See all (16)

Diagnosis

The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications.

Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP
Endocr Rev 2018 Dec 1;39(6):1029-1056. doi: 10.1210/er.2018-00060. PMID: 30007283 Free PMC Article

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.

Progress in primary aldosteronism: present challenges and perspectives.

Gomez-Sanchez CE, Rossi GP, Fallo F, Mannelli M
Horm Metab Res 2010 Jun;42(6):374-81. Epub 2010 Jan 20 doi: 10.1055/s-0029-1243619. PMID: 20091458 Free PMC Article

Neuroendocrine differentiation and nerves in human adrenal cortex and cortical lesions.

Li Q, Johansson H, Kjellman M, Grimelius L
APMIS 1998 Aug;106(8):807-17. doi: 10.1111/j.1699-0463.1998.tb00227.x. PMID: 9744767

Primary aldosteronism.

Gordon RD
J Endocrinol Invest 1995 Jul-Aug;18(7):495-511. doi: 10.1007/BF03349761. PMID: 9221268

See all (25)

Therapy

Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.

Ikoma A, Saito T, Murata M, Toyoshima H, Nakamura Y, Kawakami M, Sasano H, Ishikawa SE
Intern Med 2010;49(11):1017-21. Epub 2010 Jun 1 doi: 10.2169/internalmedicine.49.2808. PMID: 20519819

Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies.

Lefebvre H, Cartier D, Duparc C, Lihrmann I, Contesse V, Delarue C, Godin M, Fischmeister R, Vaudry H, Kuhn JM
J Clin Endocrinol Metab 2002 Mar;87(3):1211-6. doi: 10.1210/jcem.87.3.8327. PMID: 11889190

Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism.

Lefebvre H, Dhib M, Godin M, Contesse V, Delarue C, Rieu M, Wolf LM, Vaudry H, Kuhn JM
Neuroendocrinology 1997 Sep;66(3):229-33. doi: 10.1159/000127242. PMID: 9380281

Factors affecting the frequency of occurrence of spironolactone bodies in aldosteronomas and non-tumorous cortex.

Cohn D, Jackson RV, Gordon RD
Pathology 1983 Jul;15(3):273-7. doi: 10.3109/00313028309083505. PMID: 6316236

Spironolactone bodies in an adrenal adenoma.

Shrago SS, Waisman J, Cooper PH
Arch Pathol 1975 Aug;99(8):416-20. PMID: 167703

See all (6)

Prognosis

Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.

Histopathological diagnosis and prognostic factors in adrenocortical carcinoma.

Aiba M, Fujibayashi M
Endocr Pathol 2005 Spring;16(1):13-22. doi: 10.1385/ep:16:1:013. PMID: 16000842

Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene.

Honda M, Tsukada T, Horiuchi T, Tanaka R, Yamaguchi K, Obara T, Miyakawa H, Yamaji T, Ishibashi M
Intern Med 2004 Apr;43(4):310-4. doi: 10.2169/internalmedicine.43.310. PMID: 15168774

See all (3)

Clinical prediction guides

Colocalization of Wnt/β-Catenin and ACTH Signaling Pathways and Paracrine Regulation in Aldosterone-producing Adenoma.

De Sousa K, Abdellatif AB, Giscos-Douriez I, Meatchi T, Amar L, Fernandes-Rosa FL, Boulkroun S, Zennaro MC
J Clin Endocrinol Metab 2022 Jan 18;107(2):419-434. doi: 10.1210/clinem/dgab707. PMID: 34570225

Paracrine Regulation of Aldosterone Secretion in Physiological and Pathophysiological Conditions.

Lefebvre H, Duparc C, Naccache A, Lopez AG, Castanet M, Louiset E
Vitam Horm 2019;109:303-339. Epub 2018 Dec 1 doi: 10.1016/bs.vh.2018.10.001. PMID: 30678861

Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism.

Boulkroun S, Samson-Couterie B, Dzib JF, Lefebvre H, Louiset E, Amar L, Plouin PF, Lalli E, Jeunemaitre X, Benecke A, Meatchi T, Zennaro MC
Hypertension 2010 Nov;56(5):885-92. Epub 2010 Oct 11 doi: 10.1161/HYPERTENSIONAHA.110.158543. PMID: 20937967

Cell proliferation and apoptosis in normal and pathologic human adrenal.

Sasano H, Imatani A, Shizawa S, Suzuki T, Nagura H
Mod Pathol 1995 Jan;8(1):11-7. PMID: 7731935

Mineralocorticoid production of adrenal cortical adenomas.

Gláz E, Rácz K, Varga I, Kiss R, Tóth M, Fütö L
J Steroid Biochem Mol Biol 1993 Apr;45(1-3):57-64. doi: 10.1016/0960-0760(93)90122-d. PMID: 8481352

See all (36)

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