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Adenocarcinoma with Squamous Metaplasia

MedGen UID:
90777
•Concept ID:
C0334393
•
Neoplastic Process
Synonyms: Adenoacanthoma; Adenocarcinoma with squamous metaplasia
SNOMED CT: Adenocarcinoma with squamous metaplasia (15176003); Adenoacanthoma (15176003)

Definition

An invasive adenocarcinoma characterized by the presence of focal or extensive transformation of malignant glandular cells to squamous epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma with Squamous Metaplasia

Professional guidelines

PubMed

Barrett's oesophagus: epidemiology, diagnosis and clinical management.
Whiteman DC, Kendall BJ
Med J Aust 2016 Oct 3;205(7):317-24. doi: 10.5694/mja16.00796. PMID: 27681974
Bevacizumab for the treatment of cervical cancer.
Bizzarri N, Ghirardi V, Alessandri F, Venturini PL, Valenzano Menada M, Rundle S, Leone Roberti Maggiore U, Ferrero S
Expert Opin Biol Ther 2016;16(3):407-19. doi: 10.1517/14712598.2016.1145208. PMID: 26796332
Diagnosis and management of Barrett's esophagus.
Nelsen EM, Hawes RH, Iyer PG
Surg Clin North Am 2012 Oct;92(5):1135-54. Epub 2012 Aug 20 doi: 10.1016/j.suc.2012.07.009. PMID: 23026274Free PMC Article

Recent clinical studies

Etiology

Sonographic and pathological features of metaplastic squamous cell carcinoma of the breast: a case series.
Ye XJ, Chen XY, Ke ZB, Lin F, Wu YP, Yan L
BMC Surg 2021 Oct 23;21(1):374. doi: 10.1186/s12893-021-01375-0. PMID: 34688286Free PMC Article
Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast.
Honda M, Saji S, Horiguchi S, Suzuki E, Aruga T, Horiguchi K, Kitagawa D, Sekine S, Funata N, Toi M, Kuroi K
Surg Today 2011 Mar;41(3):328-32. Epub 2011 Mar 2 doi: 10.1007/s00595-009-4276-2. PMID: 21365411
Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum?
Audeau A, Han HW, Johnston MJ, Whitehead MW, Frizelle FA
Eur J Surg Oncol 2002 Sep;28(6):657-60. doi: 10.1053/ejso.2002.1304. PMID: 12359204
Human papillomavirus and mixed epithelial tumors of the endometrium.
O'Leary JJ, Landers RJ, Crowley M, Healy I, O'Donovan M, Healy V, Kealy WF, Hogan J, Doyle CT
Hum Pathol 1998 Apr;29(4):383-9. doi: 10.1016/s0046-8177(98)90120-4. PMID: 9563789
Female genital tract cancer.
Platz CE, Benda JA
Cancer 1995 Jan 1;75(1 Suppl):270-94. doi: 10.1002/1097-0142(19950101)75:1+<270::aid-cncr2820751312>3.0.co;2-d. PMID: 8001001

Diagnosis

Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast.
Honda M, Saji S, Horiguchi S, Suzuki E, Aruga T, Horiguchi K, Kitagawa D, Sekine S, Funata N, Toi M, Kuroi K
Surg Today 2011 Mar;41(3):328-32. Epub 2011 Mar 2 doi: 10.1007/s00595-009-4276-2. PMID: 21365411
Endometrial carcinoma associated with pregnancy: A report of three cases and review of the literature.
Vaccarello L, Apte SM, Copeland LJ, Boutselis JG, Rubin SC
Gynecol Oncol 1999 Jul;74(1):118-22. doi: 10.1006/gyno.1999.5369. PMID: 10385562
Human papillomavirus and mixed epithelial tumors of the endometrium.
O'Leary JJ, Landers RJ, Crowley M, Healy I, O'Donovan M, Healy V, Kealy WF, Hogan J, Doyle CT
Hum Pathol 1998 Apr;29(4):383-9. doi: 10.1016/s0046-8177(98)90120-4. PMID: 9563789
Mucin-producing adenoma associated with pancreas divisum and hepatic hilar carcinoma: an autopsy case.
Origuchi N, Kimura W, Muto T, Esaki Y
J Gastroenterol 1996 Jun;31(3):455-9. doi: 10.1007/BF02355040. PMID: 8726842
Female genital tract cancer.
Platz CE, Benda JA
Cancer 1995 Jan 1;75(1 Suppl):270-94. doi: 10.1002/1097-0142(19950101)75:1+<270::aid-cncr2820751312>3.0.co;2-d. PMID: 8001001

Therapy

Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: a long-term follow-up.
Nori D, Merimsky O, Batata M, Caputo T
Int J Radiat Oncol Biol Phys 1994 Nov 15;30(4):831-7. doi: 10.1016/0360-3016(94)90357-3. PMID: 7960984
Endometrial carcinoma in gonadal dysgenesis with and without estrogen therapy.
Ostör AG, Fortune DW, Evans JH, Kneale BL
Gynecol Oncol 1978 Aug;6(4):316-27. doi: 10.1016/0090-8258(78)90038-0. PMID: 689483

Prognosis

Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast.
Honda M, Saji S, Horiguchi S, Suzuki E, Aruga T, Horiguchi K, Kitagawa D, Sekine S, Funata N, Toi M, Kuroi K
Surg Today 2011 Mar;41(3):328-32. Epub 2011 Mar 2 doi: 10.1007/s00595-009-4276-2. PMID: 21365411
Primary squamous cell carcinoma of the breast in a young woman--a case report and review of literature.
Vidyasagar MS, Fernandes DJ, Ramanujam AS, Rao DS, Narayan R
Indian J Pathol Microbiol 1998 Oct;41(4):485-8. PMID: 9866914
Primary squamous cell carcinoma of the breast.
Weigel RJ, Ikeda DM, Nowels KW
South Med J 1996 May;89(5):511-5. doi: 10.1097/00007611-199605000-00013. PMID: 8638180
Female genital tract cancer.
Platz CE, Benda JA
Cancer 1995 Jan 1;75(1 Suppl):270-94. doi: 10.1002/1097-0142(19950101)75:1+<270::aid-cncr2820751312>3.0.co;2-d. PMID: 8001001
Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: a long-term follow-up.
Nori D, Merimsky O, Batata M, Caputo T
Int J Radiat Oncol Biol Phys 1994 Nov 15;30(4):831-7. doi: 10.1016/0360-3016(94)90357-3. PMID: 7960984

Clinical prediction guides

Mucin-producing adenoma associated with pancreas divisum and hepatic hilar carcinoma: an autopsy case.
Origuchi N, Kimura W, Muto T, Esaki Y
J Gastroenterol 1996 Jun;31(3):455-9. doi: 10.1007/BF02355040. PMID: 8726842
Characterization and radiosensitivity of UT-EC-2A and UT-EC-2B, two new highly radiosensitive endometrial cancer cell lines derived from a primary and metastatic tumor of the same patient.
Rantanen V, Grénman S, Kulmala J, Jaakkola M, Lakkala T, Sajantila A, Klemi P, Grénman R
Gynecol Oncol 1995 Jan;56(1):53-62. doi: 10.1006/gyno.1995.1009. PMID: 7821848
Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: a long-term follow-up.
Nori D, Merimsky O, Batata M, Caputo T
Int J Radiat Oncol Biol Phys 1994 Nov 15;30(4):831-7. doi: 10.1016/0360-3016(94)90357-3. PMID: 7960984

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