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Spindle cell synovial sarcoma

MedGen UID:
90795
•Concept ID:
C0334505
•
Neoplastic Process
Synonyms: Spindle Cell Synovial Sarcoma; spindle cell synovial sarcoma; Synovial sarcoma - spindle cell; Synovial Sarcoma with Spindle Cell Components; synovial sarcoma with spindle cell components; Synovial sarcoma, monophasic fibrous; synovial sarcoma, monophasic fibrous; Synovial sarcoma, spindle cell
SNOMED CT: Synovial sarcoma - spindle cell (37206003); Synovial sarcoma, monophasic fibrous (37206003); Synovial sarcoma, spindle cell (37206003)
 
Monarch Initiative: MONDO:0003466

Definition

A synovial sarcoma characterized by the presence of a spindle cell component only. [from NCI]

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Treatment of limb synovial sarcoma with metastasis at presentation.
Guo P, Zhao R, Zhou Y, Shen Y
Medicine (Baltimore) 2020 Jun 5;99(23):e20550. doi: 10.1097/MD.0000000000020550. PMID: 32502019Free PMC Article
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article

Recent clinical studies

Etiology

Primary pulmonary synovial sarcoma with calcification: A case report.
Ishida H, Fujino T, Taguchi R, Nitanda H, Sakaguchi H, Yanagihara A, Yoshimura R
Thorac Cancer 2019 Oct;10(10):2040-2044. Epub 2019 Aug 19 doi: 10.1111/1759-7714.13172. PMID: 31426131Free PMC Article

Diagnosis

Monophasic spindle cell myxoid synovial sarcoma of the hand: promising results with marginal resection.
Vijayan S, Mohammed AP, Kulkarni MS, Rao SK
BMJ Case Rep 2021 Jan 28;14(1) doi: 10.1136/bcr-2020-238366. PMID: 33509874Free PMC Article
Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case.
Sotiriou S, Kotoula V, Raptou G, Pantelaion V, Hytiroglou P
Am J Dermatopathol 2020 May;42(5):384-386. doi: 10.1097/DAD.0000000000001497. PMID: 31343425
Primary pulmonary synovial sarcoma with calcification: A case report.
Ishida H, Fujino T, Taguchi R, Nitanda H, Sakaguchi H, Yanagihara A, Yoshimura R
Thorac Cancer 2019 Oct;10(10):2040-2044. Epub 2019 Aug 19 doi: 10.1111/1759-7714.13172. PMID: 31426131Free PMC Article
Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature.
Hosono T, Hironaka M, Kobayashi A, Yamasawa H, Bando M, Ohno S, Sohara Y, Sugiyama Y
Jpn J Clin Oncol 2005 May;35(5):274-9. Epub 2005 May 6 doi: 10.1093/jjco/hyi073. PMID: 15879502
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature.
Miloro M, Quinn PD, Stewart JC
J Oral Maxillofac Surg 1994 Mar;52(3):309-13. doi: 10.1016/0278-2391(94)90308-5. PMID: 8308633

Therapy

A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma.
Krsková L, Sumerauer D, Stejskalová E, Kodet R
Diagn Mol Pathol 2007 Sep;16(3):179-83. doi: 10.1097/PDM.0b013e3180340343. PMID: 17721327

Prognosis

Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report.
Corey RM, Swett K, Ward WG
Cancer Med 2014 Oct;3(5):1404-15. Epub 2014 Jul 8 doi: 10.1002/cam4.288. PMID: 25044961Free PMC Article
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma.
Krsková L, Sumerauer D, Stejskalová E, Kodet R
Diagn Mol Pathol 2007 Sep;16(3):179-83. doi: 10.1097/PDM.0b013e3180340343. PMID: 17721327
Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature.
Hosono T, Hironaka M, Kobayashi A, Yamasawa H, Bando M, Ohno S, Sohara Y, Sugiyama Y
Jpn J Clin Oncol 2005 May;35(5):274-9. Epub 2005 May 6 doi: 10.1093/jjco/hyi073. PMID: 15879502

Clinical prediction guides

Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report.
Corey RM, Swett K, Ward WG
Cancer Med 2014 Oct;3(5):1404-15. Epub 2014 Jul 8 doi: 10.1002/cam4.288. PMID: 25044961Free PMC Article

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