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Aggressive Osteoblastoma

MedGen UID:
90805
•Concept ID:
C0334547
•
Neoplastic Process
Synonym: Aggressive osteoblastoma
SNOMED CT: Aggressive osteoblastoma (70511009)

Definition

An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts and recurrences. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive Osteoblastoma

Professional guidelines

PubMed

Surgical treatment options for aggressive osteoblastoma in the mobile spine.
Jiang L, Liu XG, Wang C, Yang SM, Liu C, Wei F, Wu FL, Zhou H, Dang L, Liu ZJ
Eur Spine J 2015 Aug;24(8):1778-85. Epub 2015 Apr 7 doi: 10.1007/s00586-015-3869-2. PMID: 25847727
Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma.
Dorfman HD, Weiss SW
Semin Diagn Pathol 1984 Aug;1(3):215-34. PMID: 6600112

Recent clinical studies

Etiology

Tailored surgery on aggressive osteoblastoma involving the cervicothoracic junction: an oncological and spinal stability long-term follow-up.
Elia A, Vitali M, Grasso V, Bertuccio A, Barbanera A
Spinal Cord Ser Cases 2021 Nov 16;7(1):99. doi: 10.1038/s41394-021-00463-w. PMID: 34789740Free PMC Article
Aggressive Cranial Osteoblastoma of the Parietotemporo-Occipital Bone: A Case Report and Review of Literature with Special Emphasis on Recurrence/Residue.
Sharma R, Mahajan S, Gupta D
World Neurosurg 2020 Oct;142:255-267. Epub 2020 Jun 20 doi: 10.1016/j.wneu.2020.06.093. PMID: 32569763
Preoperative Embolization and Complete Tumoral Resection of a Cervical Aggressive Epithelioid Osteoblastoma.
Schur S, Camlioglu E, Jung S, Powell T, Gutman G, Golan J
World Neurosurg 2017 Oct;106:1051.e1-1051.e4. Epub 2017 Jul 12 doi: 10.1016/j.wneu.2017.06.183. PMID: 28710051
Aggressive multilocular osteoblastoma in the mandible: a rare and difficult case to diagnose.
Pontual ML, Pontual AA, Grempel RG, Campos LR, Costa Ade L, Godoy GP
Braz Dent J 2014 Sep-Oct;25(5):451-6. doi: 10.1590/0103-6440201300220. PMID: 25517784
Aggressive osteoblastoma of the calcaneus.
Miyayama H, Sakamoto K, Ide M, Ise K, Hirota K, Yasunaga T, Ishihara A
Cancer 1993 Jan 15;71(2):346-53. doi: 10.1002/1097-0142(19930115)71:2<346::aid-cncr2820710213>3.0.co;2-j. PMID: 8422627

Diagnosis

Elevated β-hCG associated with aggressive Osteoblastoma.
Morris CD, Hameed MR, Agaram NP, Hwang S
Skeletal Radiol 2017 Sep;46(9):1187-1192. Epub 2017 Apr 10 doi: 10.1007/s00256-017-2647-0. PMID: 28396962
Aggressive osteoblastoma of the temporal bone: a case report and review of the literature.
Lu ZH, Cao WH, Qian WX
Clin Imaging 2013 Mar-Apr;37(2):386-9. Epub 2012 Jul 2 doi: 10.1016/j.clinimag.2012.05.017. PMID: 23465999
Aggressive osteoblastoma of the maxilla: a case report and review of the literature.
Harrington C, Accurso BT, Kalmar JR, Iwenofu OH, Agrawal A, Allen CM, Leon ME
Head Neck Pathol 2011 Jun;5(2):165-70. Epub 2010 Dec 23 doi: 10.1007/s12105-010-0234-y. PMID: 21181315Free PMC Article
Aggressive osteoblastoma.
Roessner A, Metze K, Heymer B
Pathol Res Pract 1985 Jan;179(3):433-8. doi: 10.1016/S0344-0338(85)80155-2. PMID: 3856836
Osteosarcoma resembling osteoblastoma.
Bertoni F, Unni KK, McLeod RA, Dahlin DC
Cancer 1985 Jan 15;55(2):416-26. doi: 10.1002/1097-0142(19850115)55:2<416::aid-cncr2820550221>3.0.co;2-5. PMID: 3855268

Prognosis

Tailored surgery on aggressive osteoblastoma involving the cervicothoracic junction: an oncological and spinal stability long-term follow-up.
Elia A, Vitali M, Grasso V, Bertuccio A, Barbanera A
Spinal Cord Ser Cases 2021 Nov 16;7(1):99. doi: 10.1038/s41394-021-00463-w. PMID: 34789740Free PMC Article
Aggressive Cranial Osteoblastoma of the Parietotemporo-Occipital Bone: A Case Report and Review of Literature with Special Emphasis on Recurrence/Residue.
Sharma R, Mahajan S, Gupta D
World Neurosurg 2020 Oct;142:255-267. Epub 2020 Jun 20 doi: 10.1016/j.wneu.2020.06.093. PMID: 32569763
Malignant transformation of aggressive osteoblastoma to ostesarcoma.
Görgün Ö, Salduz A, Kebudi R, Özger H, Bilgiç B
Eklem Hastalik Cerrahisi 2016 Aug;27(2):108-12. doi: 10.5606/ehc.2016.23. PMID: 27499324
Aggressive multilocular osteoblastoma in the mandible: a rare and difficult case to diagnose.
Pontual ML, Pontual AA, Grempel RG, Campos LR, Costa Ade L, Godoy GP
Braz Dent J 2014 Sep-Oct;25(5):451-6. doi: 10.1590/0103-6440201300220. PMID: 25517784
Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma.
Dorfman HD, Weiss SW
Semin Diagn Pathol 1984 Aug;1(3):215-34. PMID: 6600112

Clinical prediction guides

Atypical "Sclerosing" Osteoblastic Neoplasm: A Tumor of Intermediate Biological Potential Between Usual Osteoblastoma and Conventional Osteosarcoma.
McHugh KE, Reith JD, Lucas DR, Emory CL, Mesko NW, Kilpatrick SE
Am J Surg Pathol 2019 May;43(5):610-617. doi: 10.1097/PAS.0000000000001236. PMID: 30807304
Aggressive Osteoblastoma in the Maxilla: Unusual Lesion in the Craniofacial Skeleton.
Salmen FS, Oliveira MR, Navarro CM, Dedivitis RA, Pereira Filho VA, Gabrielli MFR
J Craniofac Surg 2017 May;28(3):794-797. doi: 10.1097/SCS.0000000000003641. PMID: 28468168
Surgical treatment options for aggressive osteoblastoma in the mobile spine.
Jiang L, Liu XG, Wang C, Yang SM, Liu C, Wei F, Wu FL, Zhou H, Dang L, Liu ZJ
Eur Spine J 2015 Aug;24(8):1778-85. Epub 2015 Apr 7 doi: 10.1007/s00586-015-3869-2. PMID: 25847727
Composite biological reconstruction following total calcanectomy of primary calcaneal tumors.
Li J, Wang Z, Guo Z, Yang M, Chen G, Pei G
J Surg Oncol 2012 Jun 1;105(7):673-8. Epub 2011 Dec 27 doi: 10.1002/jso.23022. PMID: 22213188
Aggressive osteoblastoma of the maxilla: a case report and review of the literature.
Harrington C, Accurso BT, Kalmar JR, Iwenofu OH, Agrawal A, Allen CM, Leon ME
Head Neck Pathol 2011 Jun;5(2):165-70. Epub 2010 Dec 23 doi: 10.1007/s12105-010-0234-y. PMID: 21181315Free PMC Article

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