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Anaplastic oligodendroglioma

MedGen UID:
90812
•Concept ID:
C0334590
•
Neoplastic Process
Synonyms: Anaplastic Oligodendroglioma; Anaplastic Oligodendrogliomas; Oligodendroglioma, Anaplastic; Oligodendrogliomas, Anaplastic
SNOMED CT: Anaplastic oligodendroglioma (3102004); Oligodendroglioma, anaplastic (3102004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016696
Orphanet: ORPHA251630

Definition

A rare glial tumor characterized by a grade III oligodendroglial tumour with focal or diffuse anaplastic features. It typically occurs in the supratentorial white matter. Histologically, the cells are enlarged and epithelioid with pleomorphic and increased size nuclei, a vesicular chromatin pattern and prominent nucleoli. Most patients present with seizures. [from ORDO]

Professional guidelines

PubMed

Anaplastic Glioma: Treatment Approaches in the Era of Molecular Diagnostics.
Ruff MW, Uhm J
Curr Treat Options Oncol 2018 Oct 25;19(12):61. doi: 10.1007/s11864-018-0579-0. PMID: 30361986
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Treatment updates regarding anaplastic oligodendroglioma and anaplastic oligoastrocytoma.
Khan KA, Abbasi AN, Ali N
J Coll Physicians Surg Pak 2014 Dec;24(12):935-9. PMID: 25523732

Recent clinical studies

Etiology

CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas.
Appay R, Dehais C, Maurage CA, Alentorn A, Carpentier C, Colin C, Ducray F, Escande F, Idbaih A, Kamoun A, Marie Y, Mokhtari K, Tabouret E, Trabelsi N, Uro-Coste E, Delattre JY, Figarella-Branger D; POLA Network
Neuro Oncol 2019 Dec 17;21(12):1519-1528. doi: 10.1093/neuonc/noz124. PMID: 31832685Free PMC Article
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M
Nature 2017 Sep 28;549(7673):533-537. Epub 2017 Sep 20 doi: 10.1038/nature24014. PMID: 28959975Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY, Bernsen HJ, Frenay M, Tijssen CC, Grisold W, Sipos L, Enting RH, French PJ, Dinjens WN, Vecht CJ, Allgeier A, Lacombe D, Gorlia T, Hoang-Xuan K
J Clin Oncol 2013 Jan 20;31(3):344-50. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2229. PMID: 23071237
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Diagnosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
Grade II and III Oligodendroglioma and Astrocytoma.
van den Bent MJ, Chang SM
Neurol Clin 2018 Aug;36(3):467-484. Epub 2018 Jun 15 doi: 10.1016/j.ncl.2018.04.005. PMID: 30072066
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY, Bernsen HJ, Frenay M, Tijssen CC, Grisold W, Sipos L, Enting RH, French PJ, Dinjens WN, Vecht CJ, Allgeier A, Lacombe D, Gorlia T, Hoang-Xuan K
J Clin Oncol 2013 Jan 20;31(3):344-50. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2229. PMID: 23071237

Therapy

Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY, Bernsen HJ, Frenay M, Tijssen CC, Grisold W, Sipos L, Enting RH, French PJ, Dinjens WN, Vecht CJ, Allgeier A, Lacombe D, Gorlia T, Hoang-Xuan K
J Clin Oncol 2013 Jan 20;31(3):344-50. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2229. PMID: 23071237
Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802.
Shaw EG, Wang M, Coons SW, Brachman DG, Buckner JC, Stelzer KJ, Barger GR, Brown PD, Gilbert MR, Mehta MP
J Clin Oncol 2012 Sep 1;30(25):3065-70. Epub 2012 Jul 30 doi: 10.1200/JCO.2011.35.8598. PMID: 22851558Free PMC Article
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas.
Appay R, Dehais C, Maurage CA, Alentorn A, Carpentier C, Colin C, Ducray F, Escande F, Idbaih A, Kamoun A, Marie Y, Mokhtari K, Tabouret E, Trabelsi N, Uro-Coste E, Delattre JY, Figarella-Branger D; POLA Network
Neuro Oncol 2019 Dec 17;21(12):1519-1528. doi: 10.1093/neuonc/noz124. PMID: 31832685Free PMC Article
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY, Bernsen HJ, Frenay M, Tijssen CC, Grisold W, Sipos L, Enting RH, French PJ, Dinjens WN, Vecht CJ, Allgeier A, Lacombe D, Gorlia T, Hoang-Xuan K
J Clin Oncol 2013 Jan 20;31(3):344-50. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2229. PMID: 23071237

Clinical prediction guides

Diffuse Infiltrating Oligodendroglioma and Astrocytoma.
van den Bent MJ, Smits M, Kros JM, Chang SM
J Clin Oncol 2017 Jul 20;35(21):2394-2401. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.6737. PMID: 28640702
Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article
Anaplastic oligodendroglioma and oligoastrocytoma.
van den Bent MJ
Neurol Clin 2007 Nov;25(4):1089-109, ix-x. doi: 10.1016/j.ncl.2007.07.013. PMID: 17964027

Recent systematic reviews

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Chemotherapy plus radiotherapy versus radiotherapy alone in patients with anaplastic glioma: a systematic review and meta-analysis.
Zhang L, Wu X, Xu T, Luo C, Qian J, Lu Y
J Cancer Res Clin Oncol 2013 May;139(5):719-26. Epub 2013 Feb 10 doi: 10.1007/s00432-013-1387-3. PMID: 23397358
Adjuvant chemotherapy for adults with malignant glioma: a systematic review.
Perry J, Laperriere N, Zuraw L, Chambers A, Spithoff K, Cairncross JG; Neuro-oncology Disease Site Group; Cancer Care Ontario Program in Evidence-Based Care
Can J Neurol Sci 2007 Nov;34(4):402-10. doi: 10.1017/s0317167100007265. PMID: 18062446

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