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Increased lymphocyte apoptosis

MedGen UID:
908143
•Concept ID:
C4280724
•
Finding
HPO: HP:0030887

Definition

A elevation in the rate of apoptosis in lymphocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased lymphocyte apoptosis

Professional guidelines

PubMed

Rituximab for the treatment of multiple sclerosis: a review.
Chisari CG, Sgarlata E, Arena S, Toscano S, Luca M, Patti F
J Neurol 2022 Jan;269(1):159-183. Epub 2021 Jan 8 doi: 10.1007/s00415-020-10362-z. PMID: 33416999Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Oliveira JB, Bleesing JJ, Dianzani U, Fleisher TA, Jaffe ES, Lenardo MJ, Rieux-Laucat F, Siegel RM, Su HC, Teachey DT, Rao VK
Blood 2010 Oct 7;116(14):e35-40. Epub 2010 Jun 10 doi: 10.1182/blood-2010-04-280347. PMID: 20538792Free PMC Article

Recent clinical studies

Etiology

Peripheral innate and adaptive immune cells during COVID-19: Functional neutrophils, pro-inflammatory monocytes, and half-dead lymphocytes.
Ekşioğlu-Demiralp E, Alan S, Sili U, Bakan D, Ocak İ, Yürekli R, Alpay N, Görçin S, Yıldız A
Cytometry B Clin Cytom 2022 Mar;102(2):153-167. Epub 2021 Nov 30 doi: 10.1002/cyto.b.22042. PMID: 34846101Free PMC Article
Cecal ligation puncture procedure.
Toscano MG, Ganea D, Gamero AM
J Vis Exp 2011 May 7;(51) doi: 10.3791/2860. PMID: 21587163Free PMC Article
Genetics of SCID.
Cossu F
Ital J Pediatr 2010 Nov 15;36:76. doi: 10.1186/1824-7288-36-76. PMID: 21078154Free PMC Article
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2.
Fernández-Fresnedo G, Ramos MA, González-Pardo MC, de Francisco AL, López-Hoyos M, Arias M
Nephrol Dial Transplant 2000 Apr;15(4):502-10. doi: 10.1093/ndt/15.4.502. PMID: 10727545
Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosis.
Davis IC, Girard M, Fultz PN
J Virol 1998 Jun;72(6):4623-32. doi: 10.1128/JVI.72.6.4623-4632.1998. PMID: 9573225Free PMC Article

Diagnosis

IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis.
Morrow KN, Coopersmith CM, Ford ML
Front Immunol 2019;10:1982. Epub 2019 Aug 22 doi: 10.3389/fimmu.2019.01982. PMID: 31507598Free PMC Article
Genetics of SCID.
Cossu F
Ital J Pediatr 2010 Nov 15;36:76. doi: 10.1186/1824-7288-36-76. PMID: 21078154Free PMC Article
Heightened levels of circulating 20S proteasome in critically ill patients.
Roth GA, Moser B, Krenn C, Roth-Walter F, Hetz H, Richter S, Brunner M, Jensen-Jarolim E, Wolner E, Hoetzenecker K, Boltz-Nitulescu G, Ankersmit HJ
Eur J Clin Invest 2005 Jun;35(6):399-403. doi: 10.1111/j.1365-2362.2005.01508.x. PMID: 15948901

Therapy

Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8-methoxypsoralen concentration and by replacing plasma with saline.
Hähnel V, Brosig AM, Ehrenschwender M, Burkhardt R, Offner R, Ahrens N
Transfusion 2021 Oct;61(10):2991-2999. Epub 2021 Aug 24 doi: 10.1111/trf.16634. PMID: 34427336
Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus.
Shah D, Sah S, Wanchu A, Wu MX, Bhatnagar A
Immunobiology 2013 Apr;218(4):620-7. Epub 2012 Aug 4 doi: 10.1016/j.imbio.2012.07.030. PMID: 22940256
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Oberholzer C, Oberholzer A, Bahjat FR, Minter RM, Tannahill CL, Abouhamze A, LaFace D, Hutchins B, Clare-Salzler MJ, Moldawer LL
Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11503-8. Epub 2001 Sep 11 doi: 10.1073/pnas.181338198. PMID: 11553765Free PMC Article

Prognosis

Evaluation of lymphocyte apoptosis in patients with oral cancer.
Bin-Alee F, Arayataweegool A, Buranapraditkun S, Mahattanasakul P, Tangjaturonrasme N, Mutirangura A, Kitkumthorn N
J Appl Oral Sci 2020 Sep 7;28:e20200124. doi: 10.1590/1678-7757-2020-0124. PMID: 32901694Free PMC Article
Cecal ligation puncture procedure.
Toscano MG, Ganea D, Gamero AM
J Vis Exp 2011 May 7;(51) doi: 10.3791/2860. PMID: 21587163Free PMC Article

Clinical prediction guides

Peripheral innate and adaptive immune cells during COVID-19: Functional neutrophils, pro-inflammatory monocytes, and half-dead lymphocytes.
Ekşioğlu-Demiralp E, Alan S, Sili U, Bakan D, Ocak İ, Yürekli R, Alpay N, Görçin S, Yıldız A
Cytometry B Clin Cytom 2022 Mar;102(2):153-167. Epub 2021 Nov 30 doi: 10.1002/cyto.b.22042. PMID: 34846101Free PMC Article
Lymphocyte apoptosis and macrophage function: correlation with disease activity in systemic lupus erythematosus.
Jin O, Sun LY, Zhou KX, Zhang XS, Feng XB, Mok MY, Lau CS
Clin Rheumatol 2005 Apr;24(2):107-10. Epub 2004 Jul 28 doi: 10.1007/s10067-004-0972-x. PMID: 15818511
A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans.
Gupta S
Mech Ageing Dev 2004 Feb;125(2):99-101. doi: 10.1016/j.mad.2003.11.001. PMID: 15037009
Specific changes in the posttranslational regulation of nucleolin in lymphocytes from patients infected with human immunodeficiency virus.
Galati D, Paiardini M, Cervasi B, Albrecht H, Bocchino M, Costantini A, Montroni M, Magnani M, Piedimonte G, Silvestri G
J Infect Dis 2003 Nov 15;188(10):1483-91. Epub 2003 Oct 22 doi: 10.1086/379249. PMID: 14624373
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2.
Fernández-Fresnedo G, Ramos MA, González-Pardo MC, de Francisco AL, López-Hoyos M, Arias M
Nephrol Dial Transplant 2000 Apr;15(4):502-10. doi: 10.1093/ndt/15.4.502. PMID: 10727545

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