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Clear cell squamous cell skin carcinoma

MedGen UID:
91064
•Concept ID:
C0345978
•
Neoplastic Process
Synonyms: Clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of Skin; clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of the Skin; clear cell squamous cell carcinoma of the skin; Clear Cell Squamous Cell Skin Carcinoma; clear cell squamous cell skin carcinoma; SCC - Clear cell squamous cell carcinoma of skin; Skin Clear Cell Squamous Cell Carcinoma
SNOMED CT: SCC - Clear cell squamous cell carcinoma of skin (254652000); Clear cell squamous cell carcinoma of skin (254652000)
 
Monarch Initiative: MONDO:0004523

Definition

A squamous cell carcinoma of the skin with a prominent clear cell component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell squamous cell skin carcinoma

Professional guidelines

PubMed

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Treatment considerations in actinic keratosis.
Goldenberg G
J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16. doi: 10.1111/jdv.14152. PMID: 28263018
Management of squamous cell and basal cell carcinomas of the head and neck with perineural invasion.
Gupta A, Veness M, De'Ambrosis B, Selva D, Huilgol SC
Australas J Dermatol 2016 Feb;57(1):3-13. Epub 2015 Mar 11 doi: 10.1111/ajd.12314. PMID: 25759949

Recent clinical studies

Etiology

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Clear Cell Proliferations of the Skin: A Histopathologic Review.
Zaballos P, Lara-Valencia P, Van Den Bossche K, Sánchez-Martínez E, Roca-Gines J, Vila BG, Requena L
Am J Dermatopathol 2021 Sep 1;43(9):607-636. doi: 10.1097/DAD.0000000000001881. PMID: 34411018
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma.
Santana AL, Felsen D, Carucci JA
Dermatol Clin 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003. PMID: 27890239Free PMC Article
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559

Diagnosis

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Clear Cell Proliferations of the Skin: A Histopathologic Review.
Zaballos P, Lara-Valencia P, Van Den Bossche K, Sánchez-Martínez E, Roca-Gines J, Vila BG, Requena L
Am J Dermatopathol 2021 Sep 1;43(9):607-636. doi: 10.1097/DAD.0000000000001881. PMID: 34411018
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Immunotherapy for skin cancer.
Paulson KG, Lahman MC, Chapuis AG, Brownell I
Int Immunol 2019 Jul 13;31(7):465-475. doi: 10.1093/intimm/dxz012. PMID: 30753483Free PMC Article
Onycholemmal carcinoma.
Rashid RM, Cutlan JE
Dermatol Online J 2010 Mar 15;16(3):12. PMID: 20233569

Therapy

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Current Basal and Squamous Cell Skin Cancer Management.
Mendez BM, Thornton JF
Plast Reconstr Surg 2018 Sep;142(3):373e-387e. doi: 10.1097/PRS.0000000000004696. PMID: 30148788
Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma.
Santana AL, Felsen D, Carucci JA
Dermatol Clin 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003. PMID: 27890239Free PMC Article
Chemotherapy of squamous cell carcinoma of the skin.
DeConti RC
Semin Oncol 2012 Apr;39(2):145-9. doi: 10.1053/j.seminoncol.2012.01.002. PMID: 22484186

Prognosis

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy.
Navarrete-Dechent C, Veness MJ, Droppelmann N, Uribe P
G Ital Dermatol Venereol 2018 Jun;153(3):403-418. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05936-9. PMID: 29485258
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Clinical prediction guides

The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Treatment considerations in actinic keratosis.
Goldenberg G
J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16. doi: 10.1111/jdv.14152. PMID: 28263018
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

Efficacy and prognostic factors of adjuvant radiotherapy for cutaneous squamous cell carcinoma: A systematic review and meta-analysis.
Zhang J, Wang Y, Wijaya WA, Liang Z, Chen J
J Eur Acad Dermatol Venereol 2021 Sep;35(9):1777-1787. Epub 2021 May 27 doi: 10.1111/jdv.17330. PMID: 33930213
A Systematic Review of Primary, Adjuvant, and Salvage Radiation Therapy for Cutaneous Squamous Cell Carcinoma.
Krausz AE, Ji-Xu A, Smile T, Koyfman S, Schmults CD, Ruiz ES
Dermatol Surg 2021 May 1;47(5):587-592. doi: 10.1097/DSS.0000000000002965. PMID: 33577212
Sun protection for preventing basal cell and squamous cell skin cancers.
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Keratoacanthoma clinical behavior: a systematic review.
Savage JA, Maize JC Sr
Am J Dermatopathol 2014 May;36(5):422-9. doi: 10.1097/DAD.0000000000000031. PMID: 24366198
Interventions for non-metastatic squamous cell carcinoma of the skin.
Lansbury L, Leonardi-Bee J, Perkins W, Goodacre T, Tweed JA, Bath-Hextall FJ
Cochrane Database Syst Rev 2010 Apr 14;2010(4):CD007869. doi: 10.1002/14651858.CD007869.pub2. PMID: 20393962Free PMC Article

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