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Acantholytic squamous cell skin carcinoma

MedGen UID:
91065
Concept ID:
C0345979
Neoplastic Process
Synonyms: Acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of Skin; acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of the Skin; acantholytic squamous cell carcinoma of the skin; acantholytic squamous cell skin carcinoma; Skin Acantholytic Squamous Cell Carcinoma; Skin Adenoid Squamous Cell Carcinoma; Skin Pseudoglandular Squamous Cell Carcinoma
SNOMED CT: Acantholytic squamous cell carcinoma of skin (254654004)
 
Monarch Initiative: MONDO:0004316

Definition

A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis. [from NCI]

Professional guidelines

Recent clinical studies

Etiology

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Sajin M, Hodorogea Prisăcaru A, Luchian MC, Pătraşcu OM, Dumitru A, Costache D, Dumitrescu D, Vrînceanu D, Voinea LM, Simionescu O, Costache M
Rom J Morphol Embryol 2014;55(2):279-83. PMID: 24969975
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916

Diagnosis

Shetty D, Suresh A, Acharya S, Desai A, Anehosur V, Kumar N
Stomatologija 2022;24(1):26-32. PMID: 36321707
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Ogawa T, Kiuru M, Konia TH, Fung MA
J Am Acad Dermatol 2017 Feb;76(2):327-333. Epub 2016 Nov 23 doi: 10.1016/j.jaad.2016.09.024. PMID: 27889291Free PMC Article
Satter EK
Am J Dermatopathol 2007 Oct;29(5):486-9. doi: 10.1097/DAD.0b013e318156d756. PMID: 17890923

Therapy

Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Zhu GA, Sundram U, Chang AL
JAMA Dermatol 2014 Sep;150(9):970-3. doi: 10.1001/jamadermatol.2014.583. PMID: 24740281
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916
Leshin B, White WL, Koufman JA
Arch Dermatol 1990 Jul;126(7):931-4. PMID: 2360842

Prognosis

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Garcia C, Crowson AN
Dermatol Surg 2011 Mar;37(3):353-6. doi: 10.1111/j.1524-4725.2011.01886.x. PMID: 21410819
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Apr;33(4):261-79. doi: 10.1111/j.0303-6987.2006.00516.x. PMID: 16630176

Clinical prediction guides

Kanitakis J
Am J Dermatopathol 2023 Sep 1;45(9):639-641. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002499. PMID: 37506275
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Furukawa F, Fujii K, Horiguchi Y, Matsuyoshi N, Fujita M, Toda K, Imamura S, Wakita H, Shirahama S, Takigawa M
Microsc Res Tech 1997 Aug 15;38(4):343-52. doi: 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K. PMID: 9297684
Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M, Horiguchi Y, Imamura S
J Dermatol 1994 Nov;21(11):802-13. doi: 10.1111/j.1346-8138.1994.tb03294.x. PMID: 7852640

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