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Male sexual dysfunction

MedGen UID:
910882
•Concept ID:
C1112443
•
Disease or Syndrome
HPO: HP:0040307

Definition

A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity [from HPO]

Professional guidelines

PubMed

The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review.
Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, Zhu M, Wu X, Zhang Y
Front Endocrinol (Lausanne) 2022;13:1009537. Epub 2022 Oct 18 doi: 10.3389/fendo.2022.1009537. PMID: 36329891Free PMC Article
Current and emerging treatment options for premature ejaculation.
Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
Current diagnosis and management of erectile dysfunction.
McMahon CG
Med J Aust 2019 Jun;210(10):469-476. Epub 2019 May 17 doi: 10.5694/mja2.50167. PMID: 31099420

Recent clinical studies

Etiology

European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Current diagnosis and management of erectile dysfunction.
McMahon CG
Med J Aust 2019 Jun;210(10):469-476. Epub 2019 May 17 doi: 10.5694/mja2.50167. PMID: 31099420
Premature ejaculation: an update on definition and pathophysiology.
El-Hamd MA, Saleh R, Majzoub A
Asian J Androl 2019 Sep-Oct;21(5):425-432. doi: 10.4103/aja.aja_122_18. PMID: 30860082Free PMC Article
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
Erectile dysfunction.
Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, Tan R, Mulhall JP, Hellstrom WJ
Nat Rev Dis Primers 2016 Feb 4;2:16003. doi: 10.1038/nrdp.2016.3. PMID: 27188339Free PMC Article

Diagnosis

Current and emerging treatment options for premature ejaculation.
Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Current diagnosis and management of erectile dysfunction.
McMahon CG
Med J Aust 2019 Jun;210(10):469-476. Epub 2019 May 17 doi: 10.5694/mja2.50167. PMID: 31099420
Premature ejaculation: an update on definition and pathophysiology.
El-Hamd MA, Saleh R, Majzoub A
Asian J Androl 2019 Sep-Oct;21(5):425-432. doi: 10.4103/aja.aja_122_18. PMID: 30860082Free PMC Article
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136

Therapy

The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review.
Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, Zhu M, Wu X, Zhang Y
Front Endocrinol (Lausanne) 2022;13:1009537. Epub 2022 Oct 18 doi: 10.3389/fendo.2022.1009537. PMID: 36329891Free PMC Article
Current and emerging treatment options for premature ejaculation.
Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
Current diagnosis and management of erectile dysfunction.
McMahon CG
Med J Aust 2019 Jun;210(10):469-476. Epub 2019 May 17 doi: 10.5694/mja2.50167. PMID: 31099420
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
Erectile dysfunction.
Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, Tan R, Mulhall JP, Hellstrom WJ
Nat Rev Dis Primers 2016 Feb 4;2:16003. doi: 10.1038/nrdp.2016.3. PMID: 27188339Free PMC Article

Prognosis

Substance abuse and male sexual dysfunction: what lies beneath?
Mostafa T, Alghobary M
Sex Med Rev 2023 Sep 27;11(4):395-411. doi: 10.1093/sxmrev/qead011. PMID: 37085960
The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review.
Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, Zhu M, Wu X, Zhang Y
Front Endocrinol (Lausanne) 2022;13:1009537. Epub 2022 Oct 18 doi: 10.3389/fendo.2022.1009537. PMID: 36329891Free PMC Article
Metabolically healthy and unhealthy obesity in erectile dysfunction and male infertility.
Rastrelli G, Lotti F, Reisman Y, Sforza A, Maggi M, Corona G
Expert Rev Endocrinol Metab 2019 Sep;14(5):321-334. Epub 2019 Aug 29 doi: 10.1080/17446651.2019.1657827. PMID: 31464531
Psychosocial aspects of ejaculatory dysfunction and male reproduction.
Wincze JP
Fertil Steril 2015 Nov;104(5):1089-94. Epub 2015 Aug 19 doi: 10.1016/j.fertnstert.2015.07.1155. PMID: 26297900
Male sexual dysfunction and HIV--a clinical perspective.
Santi D, Brigante G, Zona S, Guaraldi G, Rochira V
Nat Rev Urol 2014 Feb;11(2):99-109. Epub 2014 Jan 7 doi: 10.1038/nrurol.2013.314. PMID: 24394405

Clinical prediction guides

Substance abuse and male sexual dysfunction: what lies beneath?
Mostafa T, Alghobary M
Sex Med Rev 2023 Sep 27;11(4):395-411. doi: 10.1093/sxmrev/qead011. PMID: 37085960
The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review.
Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, Zhu M, Wu X, Zhang Y
Front Endocrinol (Lausanne) 2022;13:1009537. Epub 2022 Oct 18 doi: 10.3389/fendo.2022.1009537. PMID: 36329891Free PMC Article
Metabolically healthy and unhealthy obesity in erectile dysfunction and male infertility.
Rastrelli G, Lotti F, Reisman Y, Sforza A, Maggi M, Corona G
Expert Rev Endocrinol Metab 2019 Sep;14(5):321-334. Epub 2019 Aug 29 doi: 10.1080/17446651.2019.1657827. PMID: 31464531
Male sexual dysfunction and ankylosing spondylitis: a systematic review and metaanalysis.
Fan D, Liu L, Ding N, Liu S, Hu Y, Cai G, Xia G, Xin L, Wang L, Xu S, Xu J, Zou Y, Pan F
J Rheumatol 2015 Feb;42(2):252-7. Epub 2014 Dec 1 doi: 10.3899/jrheum.140416. PMID: 25448789
Male sexual dysfunction and HIV--a clinical perspective.
Santi D, Brigante G, Zona S, Guaraldi G, Rochira V
Nat Rev Urol 2014 Feb;11(2):99-109. Epub 2014 Jan 7 doi: 10.1038/nrurol.2013.314. PMID: 24394405

Recent systematic reviews

European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Male Sexual Health and Reproduction in Cutaneous Immune-Mediated Diseases: A Systematic Review.
Perez-Garcia LF, Dolhain R, Te Winkel B, Carrizales JP, Bramer WM, Vorstenbosch S, van Puijenbroek E, Hazes M, van Doorn MBA
Sex Med Rev 2021 Jul;9(3):423-433. Epub 2020 Sep 1 doi: 10.1016/j.sxmr.2020.07.004. PMID: 32883623
Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?
Soebadi MA, Milenkovic U, Weyne E, Castiglione F, Albersen M
Sex Med Rev 2017 Apr;5(2):222-235. Epub 2016 Dec 29 doi: 10.1016/j.sxmr.2016.11.002. PMID: 28041853
Antihypertensive Drugs and Male Sexual Dysfunction: A Review of Adult Hypertension Guideline Recommendations.
Al Khaja KA, Sequeira RP, Alkhaja AK, Damanhori AH
J Cardiovasc Pharmacol Ther 2016 May;21(3):233-44. Epub 2015 Oct 7 doi: 10.1177/1074248415598321. PMID: 26450998
Male sexual dysfunction and ankylosing spondylitis: a systematic review and metaanalysis.
Fan D, Liu L, Ding N, Liu S, Hu Y, Cai G, Xia G, Xin L, Wang L, Xu S, Xu J, Zou Y, Pan F
J Rheumatol 2015 Feb;42(2):252-7. Epub 2014 Dec 1 doi: 10.3899/jrheum.140416. PMID: 25448789

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Table of contents

    Clinical resources

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