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Metastatic Malignant Neoplasm in the Orbit

MedGen UID:
91116
•Concept ID:
C0347020
•
Neoplastic Process
Synonyms: Metastasis to orbit; Metastasis to the Orbit; Metastatic malignant neoplasm of orbit; Metastatic malignant neoplasm to orbit; Metastatic Malignant Neoplasm to the Orbit; Metastatic Neoplasm to the Orbit; Metastatic Tumor to the Orbit; Secondary malignant neoplasm of orbit; Secondary malignant neoplasm of orbit proper; Secondary tumor of orbit
SNOMED CT: Secondary tumor of orbit (94453007); Metastasis to orbit (94453007); Secondary malignant neoplasm of orbit (94453007); Metastatic malignant neoplasm to orbit (94453007); Secondary malignant neoplasm of orbit proper (94453007); Metastatic malignant neoplasm of orbit (94453007)

Definition

A malignant neoplasm that has spread to the orbit from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Orbit

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Clinical Management of Uveal and Conjunctival Melanoma.
Blum ES, Yang J, Komatsubara KM, Carvajal RD
Oncology (Williston Park) 2016 Jan;30(1):29-32, 34-43, 48. PMID: 26791842
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Recent clinical studies

Etiology

Ocular involvement in metastatic and systemic malignancies is not rare.
Sthapit PR, Saiju R
Cancer Rep (Hoboken) 2021 Aug;4(4):e1347. Epub 2021 Feb 3 doi: 10.1002/cnr2.1347. PMID: 33535273Free PMC Article
Carcinoid Tumors of the Orbit and Ocular Adnexa.
Mustak H, Liu W, Murta F, Ozgur O, Couch S, Garrity J, Shinder R, Kazim M, Callahan A, Hayek B, Kim H, Yu F, Esmaeli B, Rose G, Rootman D
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):217-225. doi: 10.1097/IOP.0000000000001715. PMID: 32496392
Thyroid and Eye: Where They Meet in Clinical Practice.
El-Eshmawy MM, Shahin M
Endocr Metab Immune Disord Drug Targets 2020;20(1):39-49. doi: 10.2174/1871530319666190618120107. PMID: 31237221
Orbital melanoma.
Furdova A, Chynoransky M, Krajcova P
Bratisl Lek Listy 2011;112(8):466-8. PMID: 21863619
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Diagnosis

Orbital Ependymoma.
Tsimchi IM, Malik AI, Takashima M, Lee AG
Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):e51-e54. doi: 10.1097/IOP.0000000000002095. PMID: 35030150
Metastatic Uterine Carcinosarcoma to the Orbit.
Qureshi S, Patel NA, Patel N, Ghassibi MP, Tse DT, Dubovy SR
Ophthalmic Plast Reconstr Surg 2021 Nov-Dec 01;37(6):e198-e202. doi: 10.1097/IOP.0000000000002006. PMID: 34284421Free PMC Article
Ocular involvement in metastatic and systemic malignancies is not rare.
Sthapit PR, Saiju R
Cancer Rep (Hoboken) 2021 Aug;4(4):e1347. Epub 2021 Feb 3 doi: 10.1002/cnr2.1347. PMID: 33535273Free PMC Article
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373
Orbital tumors.
Weisman RA, Kikkawa D, Moe KS, Osguthorpe JD
Otolaryngol Clin North Am 2001 Dec;34(6):1157-74, ix-x. doi: 10.1016/s0030-6665(05)70372-8. PMID: 11728939

Therapy

Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Thyroid and Eye: Where They Meet in Clinical Practice.
El-Eshmawy MM, Shahin M
Endocr Metab Immune Disord Drug Targets 2020;20(1):39-49. doi: 10.2174/1871530319666190618120107. PMID: 31237221
Sclerosing Lesions of the Orbit: A Review.
Lokdarshi G, Pushker N, Bajaj MS
Middle East Afr J Ophthalmol 2015 Oct-Dec;22(4):447-51. doi: 10.4103/0974-9233.167807. PMID: 26692715Free PMC Article
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992
Orbital cysticercosis.
Sekhar GC, Lemke BN
Ophthalmology 1997 Oct;104(10):1599-604. doi: 10.1016/s0161-6420(97)30090-6. PMID: 9331197

Prognosis

Carcinoid Tumors of the Orbit and Ocular Adnexa.
Mustak H, Liu W, Murta F, Ozgur O, Couch S, Garrity J, Shinder R, Kazim M, Callahan A, Hayek B, Kim H, Yu F, Esmaeli B, Rose G, Rootman D
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):217-225. doi: 10.1097/IOP.0000000000001715. PMID: 32496392
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373
Uveal melanoma: epidemiologic aspects.
Singh AD, Bergman L, Seregard S
Ophthalmol Clin North Am 2005 Mar;18(1):75-84, viii. doi: 10.1016/j.ohc.2004.07.002. PMID: 15763193
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Clinical prediction guides

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions.
Ji H, Hu C, Yang X, Liu Y, Ji G, Ge S, Wang X, Wang M
Signal Transduct Target Ther 2023 Sep 27;8(1):367. doi: 10.1038/s41392-023-01576-4. PMID: 37752146Free PMC Article
Dacryops and clinical diagnostic challenges.
Alsarhani WK, Al-Sharif EM, Al-Faky YH, Alkatan HM, Maktabi AM, Alsuhaibani AH
Can J Ophthalmol 2022 Dec;57(6):388-393. Epub 2021 Jul 26 doi: 10.1016/j.jcjo.2021.06.014. PMID: 34324876
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Recent systematic reviews

Metastatic Meningioma of the Neck: A Case Report and Systematic Review.
Nguyen HCB, Mady LJ, Panara K, Andrianus S, Cooper K, Chen IH, Chalian AA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2022;84(5):361-369. Epub 2022 Feb 3 doi: 10.1159/000521076. PMID: 35114675
The role of adjuvant systemic steroids in the management of periorbital cellulitis secondary to sinusitis: a systematic review and meta-analysis.
Mahalingam S, Luke L, Pundir J, Pundir V
Eur Arch Otorhinolaryngol 2021 Jul;278(7):2193-2201. Epub 2020 Aug 24 doi: 10.1007/s00405-020-06294-z. PMID: 32833055
Ophthalmic involvement of chronic lymphocytic leukemia: A systematic review of 123 cases.
Delestre F, Blanche P, Bouayed E, Bouscary D, Mouthon L, Brezin A, Le Jeunne C, Chaigne B
Surv Ophthalmol 2021 Jan-Feb;66(1):124-131. Epub 2020 May 11 doi: 10.1016/j.survophthal.2020.05.001. PMID: 32407752
High frequency of lobular breast cancer in distant metastases to the orbit.
Raap M, Antonopoulos W, Dämmrich M, Christgen H, Steinmann D, Länger F, Lehmann U, Kreipe H, Christgen M
Cancer Med 2015 Jan;4(1):104-11. Epub 2014 Oct 30 doi: 10.1002/cam4.331. PMID: 25355547Free PMC Article
Cutaneous malignant melanoma metastatic to the eye, lids, and orbit.
Rosenberg C, Finger PT
Surv Ophthalmol 2008 May-Jun;53(3):187-202. doi: 10.1016/j.survophthal.2008.02.003. PMID: 18501266

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