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Benign Paranasal Sinus Neoplasm

MedGen UID:
91122
•Concept ID:
C0347222
•
Neoplastic Process
Synonyms: Benign Accessory Sinus Neoplasm; Benign Accessory Sinus Tumor; Benign Nasal Sinus Neoplasm; Benign Nasal Sinus Tumor; Benign neoplasm of accessory sinus; Benign Neoplasm of Accessory Sinus; Benign neoplasm of nasal sinus; Benign Neoplasm of Nasal Sinus; Benign Neoplasm of Paranasal Sinus; Benign Neoplasm of the Accessory Sinus; Benign Neoplasm of the Nasal Sinus; Benign Neoplasm of the Paranasal Sinus; Benign Paranasal Sinus Tumor; Benign Tumor of Accessory Sinus; Benign Tumor of Nasal Sinus; Benign tumor of nasal sinuses; Benign Tumor of Paranasal Sinus; Benign Tumor of the Accessory Sinus; Benign Tumor of the Nasal Sinus; Benign Tumor of the Paranasal Sinus
SNOMED CT: Benign neoplasm of accessory sinus (91961008); Benign neoplasm of nasal sinus (91961008); Benign tumor of nasal sinuses (91961008)

Definition

A neoplasm that arises from the paranasal sinuses and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Schneiderian papilloma and salivary gland-type adenoma. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Diagnosis, Treatment and Follow-Up of Sinonasal Leiomyomas: A Systematic Review.
Runge A, Randhawa A, Mayo-Patiño M, Santer M, Hartl R, Dejaco D, Eloy JA
Am J Rhinol Allergy 2023 Sep;37(5):586-592. Epub 2023 Apr 24 doi: 10.1177/19458924231170464. PMID: 37093753
Gigantic paranasal sinuses osteomas: clinical features, management considerations, and long-term outcomes.
Giotakis E, Sofokleous V, Delides A, Razou A, Pallis G, Karakasi A, Maragoudakis P
Eur Arch Otorhinolaryngol 2021 May;278(5):1429-1441. Epub 2020 Oct 16 doi: 10.1007/s00405-020-06420-x. PMID: 33064177

Recent clinical studies

Etiology

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Frontoethmoidal mucocele presenting with ocular manifestations.
Roncone DP
Clin Exp Optom 2020 Sep;103(5):610-617. Epub 2019 Nov 26 doi: 10.1111/cxo.13006. PMID: 31773805
Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions.
Thompson LDR, Fanburg-Smith JC
Head Neck Pathol 2016 Mar;10(1):95-108. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0697-6. PMID: 26830398Free PMC Article
Sinonasal schneiderian papilloma.
Yoskovitch A, Braverman I, Nachtigal D, Frenkiel S, Rochon L, Black MJ
J Otolaryngol 1998 Jun;27(3):122-6. PMID: 9664239
Inverted papilloma.
Weissler MC, Montgomery WW, Turner PA, Montgomery SK, Joseph MP
Ann Otol Rhinol Laryngol 1986 May-Jun;95(3 Pt 1):215-21. doi: 10.1177/000348948609500301. PMID: 3717844

Diagnosis

Sinonasal Ameloblastoma.
Barrena BG, Phillips BJ, Moran KJ, Betz SJ
Head Neck Pathol 2019 Jun;13(2):247-250. Epub 2018 May 30 doi: 10.1007/s12105-018-0933-3. PMID: 29846904Free PMC Article
Maxillary sinus schwannoma.
Alim BM, Jomah M, Al-Thobaiti M
BMJ Case Rep 2018 May 30;2018 doi: 10.1136/bcr-2017-223946. PMID: 29848526Free PMC Article
Paranasal sinus osteomas.
Çelenk F, Baysal E, Karata ZA, Durucu C, Mumbuç S, Kanlıkama M
J Craniofac Surg 2012 Sep;23(5):e433-7. doi: 10.1097/SCS.0b013e31825e4b5b. PMID: 22976695
Imaging of sinonasal tumours.
Eggesbø HB
Cancer Imaging 2012 May 7;12:136-52. doi: 10.1102/1470-7330.2012.0015. PMID: 22571851Free PMC Article
Paranasal sinus imaging.
Maroldi R, Ravanelli M, Borghesi A, Farina D
Eur J Radiol 2008 Jun;66(3):372-86. Epub 2008 Mar 28 doi: 10.1016/j.ejrad.2008.01.059. PMID: 18375083

Therapy

Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review.
Li H, Wang H, Wang D
Braz J Otorhinolaryngol 2022 Nov-Dec;88 Suppl 5(Suppl 5):S171-S178. Epub 2022 Feb 15 doi: 10.1016/j.bjorl.2022.02.001. PMID: 35256287Free PMC Article
Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective.
Homma A, Nakamaru Y, Lund VJ, Hanna EY, Kowalski LP, Toledo RN, Mäkitie AA, Rodrigo JP, Rinaldo A, Snyderman CH, Ferlito A
Auris Nasus Larynx 2021 Feb;48(1):41-49. Epub 2020 Dec 4 doi: 10.1016/j.anl.2020.11.018. PMID: 33280972
Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery.
Rotsides JM, Franco A, Albader A, Casiano RR, Lieberman SM
Ann Otol Rhinol Laryngol 2019 Oct;128(10):932-937. Epub 2019 May 14 doi: 10.1177/0003489419848454. PMID: 31088142
Sinonasal and ventral skull base inflammatory pseudotumor: a systematic review.
Desai SV, Spinazzi EF, Fang CH, Huang G, Tomovic S, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Apr;125(4):813-21. Epub 2014 Nov 6 doi: 10.1002/lary.24993. PMID: 25376630
Radiation therapy: posterior segment complications.
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:114-23. Epub 2013 Aug 26 doi: 10.1159/000351088. PMID: 23989132

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Sinonasal Ameloblastoma.
Barrena BG, Phillips BJ, Moran KJ, Betz SJ
Head Neck Pathol 2019 Jun;13(2):247-250. Epub 2018 May 30 doi: 10.1007/s12105-018-0933-3. PMID: 29846904Free PMC Article
Imaging and resectability issues of sinonasal tumors.
Singh N, Eskander A, Huang SH, Curtin H, Bartlett E, Vescan A, Kraus D, O'Sullivan B, Gentili F, Gullane P, Yu E
Expert Rev Anticancer Ther 2013 Mar;13(3):297-312. doi: 10.1586/era.13.5. PMID: 23477517
Imaging of sinonasal tumours.
Eggesbø HB
Cancer Imaging 2012 May 7;12:136-52. doi: 10.1102/1470-7330.2012.0015. PMID: 22571851Free PMC Article
Benign cysts and tumors of the paranasal sinuses.
Pierse JE, Stern A
Oral Maxillofac Surg Clin North Am 2012 May;24(2):249-64, ix. Epub 2012 Feb 14 doi: 10.1016/j.coms.2012.01.007. PMID: 22341510

Clinical prediction guides

Gigantic paranasal sinuses osteomas: clinical features, management considerations, and long-term outcomes.
Giotakis E, Sofokleous V, Delides A, Razou A, Pallis G, Karakasi A, Maragoudakis P
Eur Arch Otorhinolaryngol 2021 May;278(5):1429-1441. Epub 2020 Oct 16 doi: 10.1007/s00405-020-06420-x. PMID: 33064177
The Management of the Paranasal Sinus Osteomas.
Arslan HH, Tasli H, Cebeci S, Gerek M
J Craniofac Surg 2017 May;28(3):741-745. doi: 10.1097/SCS.0000000000003397. PMID: 28468156
Paranasal sinus osteomas: Diagnosis and treatment.
Chahed H, Hachicha H, Bachraoui R, Marrakchi J, Mediouni A, Zainine R, Ben Amor M, Beltaief N, Besbes G
Rev Stomatol Chir Maxillofac Chir Orale 2016 Nov;117(5):306-310. Epub 2016 Aug 3 doi: 10.1016/j.revsto.2016.04.007. PMID: 27496644
Unilateral sinonasal symptoms.
Habesoglu TE, Habesoglu M, Surmeli M, Uresin T, Egeli E
J Craniofac Surg 2010 Nov;21(6):2019-22. doi: 10.1097/SCS.0b013e3181f5389a. PMID: 21119491
Schneiderian papillomas and carcinomas: a review.
Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

Recent systematic reviews

Diagnosis, Treatment and Follow-Up of Sinonasal Leiomyomas: A Systematic Review.
Runge A, Randhawa A, Mayo-Patiño M, Santer M, Hartl R, Dejaco D, Eloy JA
Am J Rhinol Allergy 2023 Sep;37(5):586-592. Epub 2023 Apr 24 doi: 10.1177/19458924231170464. PMID: 37093753
Extra Nodal Rosai-Dorfman Disease Originating in the Nasal and Paranasal Complex and Gnathic Bones: A Systematic Analysis of Seven Cases and Review of Literature.
Ojha J, Rawal YB, Hornick JL, Magliocca K, Montgomery DR, Foss RD, Torske KR, Accurso B
Head Neck Pathol 2020 Jun;14(2):442-453. Epub 2019 Jul 31 doi: 10.1007/s12105-019-01056-8. PMID: 31368076Free PMC Article
Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.
Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD
Am J Rhinol Allergy 2018 May;32(3):167-174. Epub 2018 Apr 12 doi: 10.1177/1945892418765004. PMID: 29649889
Isolated sphenoid sinus opacifications: a systematic review and meta-analysis.
Moss WJ, Finegersh A, Jafari A, Panuganti B, Coffey CS, DeConde A, Husseman J
Int Forum Allergy Rhinol 2017 Dec;7(12):1201-1206. Epub 2017 Oct 12 doi: 10.1002/alr.22023. PMID: 29024448
Sinonasal and ventral skull base inflammatory pseudotumor: a systematic review.
Desai SV, Spinazzi EF, Fang CH, Huang G, Tomovic S, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Apr;125(4):813-21. Epub 2014 Nov 6 doi: 10.1002/lary.24993. PMID: 25376630

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