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Benign neoplasm of large intestine

MedGen UID:
91125
•Concept ID:
C0347272
•
Neoplastic Process
Synonyms: Benign Colorectal Neoplasm; benign colorectal neoplasm; Benign Colorectal Neoplasms; benign colorectal neoplasms; Benign Colorectal Tumor; benign colorectal tumor; Benign Colorectal Tumors; benign colorectal tumors; benign colorectal tumour; benign colorectal tumours; Benign Large Bowel Neoplasm; benign large bowel neoplasm; Benign Large Bowel Tumor; benign large bowel tumor; benign large bowel tumour; Benign Large Intestine Neoplasm; benign large intestine neoplasm; Benign Large Intestine Tumor; benign large intestine tumor; benign large intestine tumour; Benign Neoplasm of Large Bowel; benign neoplasm of large bowel; Benign Neoplasm of Large Intestine; benign neoplasm of large intestine; Benign Neoplasm of the Large Bowel; benign neoplasm of the large bowel; Benign Neoplasm of the Large Intestine; benign neoplasm of the large intestine; Benign Tumor of Large Bowel; benign tumor of large bowel; Benign tumor of large intestine; Benign Tumor of Large Intestine; benign tumor of large intestine; Benign Tumor of the Large Bowel; benign tumor of the large bowel; Benign Tumor of the Large Intestine; benign tumor of the large intestine; benign tumour of large bowel; benign tumour of large intestine; benign tumour of the large bowel; benign tumour of the large intestine; Colorectal Neoplasms, Benign; colorectal neoplasms, benign; Colorectal Tumors, Benign; colorectal tumors, benign; large intestine benign neoplasm; Neoplasms, Colorectal, Benign; neoplasms, colorectal, benign; Tumors, Colorectal, Benign; tumors, colorectal, benign
SNOMED CT: Benign tumor of large intestine (92170008); Benign neoplasm of large intestine (92170008)
 
Monarch Initiative: MONDO:0021444

Definition

A neoplasm that arises from the colon or rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Cystic lesions of the retrorectal space.
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Colorectal polyps in childhood.
Thakkar K, Fishman DS, Gilger MA
Curr Opin Pediatr 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f. PMID: 22890064
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344

Diagnosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
GISTs of the large intestine: review of the literature.
Syllaios A, Schizas D, Davakis S, Koutras A, Vailas M, Machairas N, Mpaili E, Felekouras E
J BUON 2020 Jan-Feb;25(1):15-22. PMID: 32277610
Attenuated adenomatous polyposis of the large bowel: Present and future.
Roncucci L, Pedroni M, Mariani F
World J Gastroenterol 2017 Jun 21;23(23):4135-4139. doi: 10.3748/wjg.v23.i23.4135. PMID: 28694653Free PMC Article
Colonoscopy.
Kaminski MF, Zagorowicz E
Gastrointest Endosc 2014 Sep;80(3):400-3. doi: 10.1016/j.gie.2014.07.005. PMID: 25127944
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours.
Dawod M, Gordoa TA, Cives M, De Mestier L, Crona J, Spada F, Oberg K, Pavel M, Lamarca A
Curr Treat Options Oncol 2021 Jun 29;22(8):73. doi: 10.1007/s11864-021-00863-y. PMID: 34185197
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Definition of the Rectum: An International, Expert-based Delphi Consensus.
DʼSouza N, de Neree Tot Babberich MPM, d'Hoore A, Tiret E, Xynos E, Beets-Tan RGH, Nagtegaal ID, Blomqvist L, Holm T, Glimelius B, Lacy A, Cervantes A, Glynne-Jones R, West NP, Perez RO, Quadros C, Lee KY, Madiba TE, Wexner SD, Garcia-Aguilar J, Sahani D, Moran B, Tekkis P, Rutten HJ, Tanis PJ, Wiggers T, Brown G
Ann Surg 2019 Dec;270(6):955-959. doi: 10.1097/SLA.0000000000003251. PMID: 30973385
Colorectal polyps in childhood.
Thakkar K, Fishman DS, Gilger MA
Curr Opin Pediatr 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f. PMID: 22890064

Prognosis

GISTs of the large intestine: review of the literature.
Syllaios A, Schizas D, Davakis S, Koutras A, Vailas M, Machairas N, Mpaili E, Felekouras E
J BUON 2020 Jan-Feb;25(1):15-22. PMID: 32277610
Review of computed tomographic colonography from a surgeon's perspective.
Bellows C, Gagliardi G, Bacigalupo L
J Gastrointestin Liver Dis 2015 Jun;24(2):215-23. doi: 10.15403/jgld.2014.1121.242.blws. PMID: 26114182
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344
An overview of adenocarcinoma of the small intestine.
Neugut AI, Marvin MR, Rella VA, Chabot JA
Oncology (Williston Park) 1997 Apr;11(4):529-36; discussion 545, 549-50. PMID: 9130275
Neoplastic obstruction of the small and large intestine.
Greenlee HB, Aranha GV, DeOrio AJ
Curr Probl Cancer 1979 Aug;4(2):1-49. doi: 10.1016/s0147-0272(79)80036-7. PMID: 391493

Clinical prediction guides

The Frontiers of Appendiceal Controversies: Mucinous Neoplasms and Pseudomyxoma Peritonei.
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review.
Murthy SK, Feuerstein JD, Nguyen GC, Velayos FS
Gastroenterology 2021 Sep;161(3):1043-1051.e4. doi: 10.1053/j.gastro.2021.05.063. PMID: 34416977
Attenuated adenomatous polyposis of the large bowel: Present and future.
Roncucci L, Pedroni M, Mariani F
World J Gastroenterol 2017 Jun 21;23(23):4135-4139. doi: 10.3748/wjg.v23.i23.4135. PMID: 28694653Free PMC Article
What influences preneoplastic colorectal lesion recurrence?
De Maio G, Zama E, Rengucci C, Calistri D
Oncotarget 2017 Feb 14;8(7):12406-12416. doi: 10.18632/oncotarget.13628. PMID: 27902488Free PMC Article
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.
Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA, Holt RA
Genome Res 2012 Feb;22(2):299-306. Epub 2011 Oct 18 doi: 10.1101/gr.126516.111. PMID: 22009989Free PMC Article

Recent systematic reviews

Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis.
Xiang J, Yan H, Li J, Wang X, Chen H, Zheng X
World J Surg Oncol 2019 Feb 13;17(1):31. doi: 10.1186/s12957-019-1573-0. PMID: 30760274Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

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