U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anal melanoma

MedGen UID:
91151
•Concept ID:
C0349538
•
Neoplastic Process
Synonyms: Anal Malignant Melanoma; anal malignant melanoma; Anal Melanoma; anal melanoma; anus melanoma; anus melanoma (disease); Cancer anal melanoma; malignant anus melanoma; Malignant melanoma of anus; Malignant Melanoma of Anus; malignant melanoma of anus; Malignant Melanoma of the Anus; malignant melanoma of the anus; melanoma (disease) of anus; Melanoma of Anus; melanoma of anus; Melanoma of the Anus; melanoma of the anus
SNOMED CT: Cancer anal melanoma (276821000); Malignant melanoma of anus (276821000)
 
Monarch Initiative: MONDO:0006081

Definition

A melanoma arising from the anus. Clinical presentation includes rectal bleeding, tenesmus, pain, and change in bowel habit. The prognosis is usually poor. [from NCI]

Professional guidelines

PubMed

Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment.
Longo WE, Vernava AM 3rd, Wade TP, Coplin MA, Virgo KS, Johnson FE
Am Surg 1995 Jun;61(6):495-500. PMID: 7762897

Recent clinical studies

Etiology

Impact of adjuvant therapies following surgery for anal melanoma.
Wong DL, Glazer ES, Tsao M, Deneve JL, Fleming MD, Shibata D
Am J Surg 2022 Jun;223(6):1132-1143. Epub 2021 Nov 11 doi: 10.1016/j.amjsurg.2021.10.041. PMID: 34801225
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Anal melanoma: Outcomes of current surgical approaches.
Kaya S, Kement M, Altuntas YE, Altin O, Seker A, Mazmanoglu S, Kaptanoglu L, Bildik N, Kucuk HF
Niger J Clin Pract 2018 Dec;21(12):1622-1626. doi: 10.4103/njcp.njcp_254_18. PMID: 30560827
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967

Diagnosis

Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Anal melanoma: Outcomes of current surgical approaches.
Kaya S, Kement M, Altuntas YE, Altin O, Seker A, Mazmanoglu S, Kaptanoglu L, Bildik N, Kucuk HF
Niger J Clin Pract 2018 Dec;21(12):1622-1626. doi: 10.4103/njcp.njcp_254_18. PMID: 30560827
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005

Therapy

Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005
Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.
Falch C, Mueller S, Kirschniak A, Braun M, Koenigsrainer A, Klumpp B
World J Surg Oncol 2016 Jul 15;14(1):185. doi: 10.1186/s12957-016-0938-x. PMID: 27422527Free PMC Article
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Pregnancy and maternal outcomes in women with prior or current gastrointestinal malignancies.
Al-Ibrahim A, Parrish J, Dunn E, Swallow C, Maxwell C
J Obstet Gynaecol Can 2014 Jan;36(1):34-41. doi: 10.1016/S1701-2163(15)30681-2. PMID: 24444285
Melanoma of the anal canal: a case series.
Homsi J, Garrett C
Dis Colon Rectum 2007 Jul;50(7):1004-10. doi: 10.1007/s10350-007-0242-5. PMID: 17468984

Prognosis

Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study.
Zheng Y, Cong C, Su C, Sun Y, Xing L
Int J Clin Oncol 2020 Nov;25(11):1951-1959. Epub 2020 Aug 1 doi: 10.1007/s10147-020-01759-x. PMID: 32740718
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005

Clinical prediction guides

Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Successful Restoration of Fecal Continence Using Sacral Nerve Stimulation Following Chemoradiation and Transanal Excision of an Anal Melanoma With Partial Internal Anal Sphincter Resection: A Case Report.
Tolopka TC, Messick CA
Neuromodulation 2017 Dec;20(8):783-786. Epub 2017 Feb 1 doi: 10.1111/ner.12562. PMID: 28150422
Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis.
Chen H, Cai Y, Liu Y, He J, Hu Y, Xiao Q, Hu W, Ding K
Medicine (Baltimore) 2016 Feb;95(7):e2770. doi: 10.1097/MD.0000000000002770. PMID: 26886623Free PMC Article
Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry.
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Anal versus rectal melanoma: does site of origin predict outcome?
Bello DM, Smyth E, Perez D, Khan S, Temple LK, Ariyan CE, Weiser MR, Carvajal RD
Dis Colon Rectum 2013 Feb;56(2):150-7. doi: 10.1097/DCR.0b013e31827901dd. PMID: 23303142Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...