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Endometrial Metaplasia

MedGen UID:
923195
•Concept ID:
C1396635
•
Disease or Syndrome

Definition

A morphologic finding indicating the alteration of the mature endometrial glandular epithelium to another that differs from that of normal endometrioid glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Metaplasia

Professional guidelines

PubMed

Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients.
Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, Luo X
Arch Gynecol Obstet 2022 Oct;306(4):1135-1146. Epub 2022 Mar 4 doi: 10.1007/s00404-021-06382-3. PMID: 35246715Free PMC Article

Recent clinical studies

Etiology

Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients.
Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, Luo X
Arch Gynecol Obstet 2022 Oct;306(4):1135-1146. Epub 2022 Mar 4 doi: 10.1007/s00404-021-06382-3. PMID: 35246715Free PMC Article
Morular endometrial metaplasia: review of the literature and proposal of the management.
Litta P, Codroma A, D'Agostino G, Breda E
Eur J Gynaecol Oncol 2013;34(3):243-7. PMID: 23967555
Nonneoplastic findings in loop electrical excision procedure specimens from patients with persistent atypical squamous cells of uncertain significance in two consecutive pap smears.
Pinto AP, Tuon FF, Tizzot EL, Torres LF, Collaço LM
Diagn Cytopathol 2002 Aug;27(2):123-7. doi: 10.1002/dc.10133. PMID: 12203882
Immunohistochemical detection of p53 and bcl-2 proteins in neoplastic and non-neoplastic endocervical glandular lesions.
McCluggage G, McBride H, Maxwell P, Bharucha H
Int J Gynecol Pathol 1997 Jan;16(1):22-7. doi: 10.1097/00004347-199701000-00004. PMID: 8986528
Endometrial metaplasia associated with endometrial adenocarcinoma.
Andersen WA, Taylor PT Jr, Fechner RE, Pinkerton JA
Am J Obstet Gynecol 1987 Sep;157(3):597-604. doi: 10.1016/s0002-9378(87)80013-3. PMID: 3631161

Diagnosis

Endometrial metaplasia: correlation of histological and cytological specimens obtained from 103 cases undergoing hysterectomy for endometrial carcinoma.
Toomine Y, Watanabe S, Ohishi Y, Tamiya S, Sugishima S, Kobayashi H, Oda Y, Kaku T
Cytopathology 2014 Apr;25(2):78-85. Epub 2013 Mar 20 doi: 10.1111/cyt.12055. PMID: 23517058
Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia.
Cameron RI, Maxwell P, Jenkins D, McCluggage WG
Histopathology 2002 Oct;41(4):313-21. doi: 10.1046/j.1365-2559.2002.01465.x. PMID: 12383213
p53 immunoreactivity in endometrial metaplasia with dysfunctional uterine bleeding.
Quddus MR, Sung CJ, Zheng W, Lauchlan SC
Histopathology 1999 Jul;35(1):44-9. doi: 10.1046/j.1365-2559.1999.00684.x. PMID: 10383713
The prevalence of tubo-endometrial metaplasia and adenomatoid proliferation.
al-Nafussi A, Rahilly M
Histopathology 1993 Feb;22(2):177-9. doi: 10.1111/j.1365-2559.1993.tb00099.x. PMID: 8454263
Endometrial metaplasia associated with endometrial adenocarcinoma.
Andersen WA, Taylor PT Jr, Fechner RE, Pinkerton JA
Am J Obstet Gynecol 1987 Sep;157(3):597-604. doi: 10.1016/s0002-9378(87)80013-3. PMID: 3631161

Therapy

Endometrial tubal metaplasia in a young puerperal woman after breast cancer.
Di Benedetto L, Giovanale V, Caserta D
Int J Clin Exp Pathol 2015;8(6):7610-3. Epub 2015 Jun 1 PMID: 26261678Free PMC Article

Prognosis

p53 immunoreactivity in endometrial metaplasia with dysfunctional uterine bleeding.
Quddus MR, Sung CJ, Zheng W, Lauchlan SC
Histopathology 1999 Jul;35(1):44-9. doi: 10.1046/j.1365-2559.1999.00684.x. PMID: 10383713
Endometrial carcinoma associated with hyperplasia.
Kaku T, Tsukamoto N, Hachisuga T, Tsuruchi N, Sakai K, Hirakawa T, Amada S, Saito T, Kamura T, Nakano H
Gynecol Oncol 1996 Jan;60(1):22-5. doi: 10.1006/gyno.1996.0005. PMID: 8557221
Endometrial metaplasia associated with endometrial carcinoma.
Kaku T, Tsukamoto N, Tsuruchi N, Sugihara K, Kamura T, Nakano H
Obstet Gynecol 1992 Nov;80(5):812-6. PMID: 1407921

Clinical prediction guides

Precursor Lesions of Cervical Clear Cell Carcinoma: Evidence For Origin From Tubo-Endometrial Metaplasia.
Talia KL, Arora R, McCluggage WG
Int J Gynecol Pathol 2022 Mar 1;41(2):105-112. doi: 10.1097/PGP.0000000000000785. PMID: 33770055
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729

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