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Primary Peritoneal High Grade Serous Adenocarcinoma

MedGen UID:
925904
•Concept ID:
C4288372
•
Neoplastic Process
Synonym: Primary Peritoneal High-Grade Serous Adenocarcinoma

Definition

A serous adenocarcinoma that arises from the lining of the peritoneum. It is characterized by high grade histopathologic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Peritoneal High Grade Serous Adenocarcinoma

Professional guidelines

PubMed

BRCA testing in women with high-grade serous ovarian cancer: gynecologic oncologist-initiated testing compared with genetics referral.
Piedimonte S, Power J, Foulkes WD, Weber E, Palma L, Schiavi A, Ambrosio E, Konci R, Gilbert L, Jardon K, Baret L, Zeng X
Int J Gynecol Cancer 2020 Nov;30(11):1757-1761. Epub 2020 Aug 5 doi: 10.1136/ijgc-2020-001261. PMID: 32759180
First-Line Management of Advanced High-Grade Serous Ovarian Cancer.
Mahmood RD, Morgan RD, Edmondson RJ, Clamp AR, Jayson GC
Curr Oncol Rep 2020 Jun 4;22(6):64. doi: 10.1007/s11912-020-00933-8. PMID: 32494876Free PMC Article
Primary site assignment in tubo-ovarian high-grade serous carcinoma: Consensus statement on unifying practice worldwide.
Singh N, Gilks CB, Hirschowitz L, Kehoe S, McNeish IA, Miller D, Naik R, Wilkinson N, McCluggage WG
Gynecol Oncol 2016 May;141(2):195-198. Epub 2016 Jan 28 doi: 10.1016/j.ygyno.2015.10.022. PMID: 26827965

Recent clinical studies

Etiology

Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma.
Nik NN, Vang R, Shih IeM, Kurman RJ
Annu Rev Pathol 2014;9:27-45. Epub 2013 Aug 5 doi: 10.1146/annurev-pathol-020712-163949. PMID: 23937438
Low-grade serous primary peritoneal carcinoma.
Schmeler KM, Sun CC, Malpica A, Deavers MT, Bodurka DC, Gershenson DM
Gynecol Oncol 2011 Jun 1;121(3):482-6. Epub 2011 Mar 11 doi: 10.1016/j.ygyno.2011.02.017. PMID: 21397305

Diagnosis

Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology.
Brown Y, Hua S, Tanwar PS
Matrix Biol 2023 Apr;118:16-46. Epub 2023 Feb 11 doi: 10.1016/j.matbio.2023.02.004. PMID: 36781087
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Assignment of primary site in high-grade serous tubal, ovarian and peritoneal carcinoma: a proposal.
Singh N, Gilks CB, Wilkinson N, McCluggage WG
Histopathology 2014 Aug;65(2):149-54. Epub 2014 May 20 doi: 10.1111/his.12419. PMID: 24660659
Low-grade serous primary peritoneal carcinoma.
Schmeler KM, Sun CC, Malpica A, Deavers MT, Bodurka DC, Gershenson DM
Gynecol Oncol 2011 Jun 1;121(3):482-6. Epub 2011 Mar 11 doi: 10.1016/j.ygyno.2011.02.017. PMID: 21397305
Primary peritoneal serous borderline tumors.
Hutton RL, Dalton SR
Arch Pathol Lab Med 2007 Jan;131(1):138-44. doi: 10.5858/2007-131-138-PPSBT. PMID: 17227115

Therapy

LRP1B-a prognostic marker in tubo-ovarian high-grade serous carcinoma.
Kolb S, Hoffmann I, Monjé N, Dragomir MP, Jank P, Bischoff P, Keunecke C, Pohl J, Kunze CA, Marchenko S, Schmitt WD, Kulbe H, Sers C, Sehouli J, Braicu EI, Denkert C, Darb-Esfahani S, Horst D, Sinn BV, Taube ET
Hum Pathol 2023 Nov;141:158-168. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.001. PMID: 37742945
HIPEC in Ovarian Cancer: When and to Whom?
Ates O, Aksel B, Akkus MH, Oner I, Yuksel C, Dogan M
J Coll Physicians Surg Pak 2023 Sep;33(9):1001-1005. doi: 10.29271/jcpsp.2023.09.1001. PMID: 37691361
Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
First-Line Management of Advanced High-Grade Serous Ovarian Cancer.
Mahmood RD, Morgan RD, Edmondson RJ, Clamp AR, Jayson GC
Curr Oncol Rep 2020 Jun 4;22(6):64. doi: 10.1007/s11912-020-00933-8. PMID: 32494876Free PMC Article

Prognosis

LRP1B-a prognostic marker in tubo-ovarian high-grade serous carcinoma.
Kolb S, Hoffmann I, Monjé N, Dragomir MP, Jank P, Bischoff P, Keunecke C, Pohl J, Kunze CA, Marchenko S, Schmitt WD, Kulbe H, Sers C, Sehouli J, Braicu EI, Denkert C, Darb-Esfahani S, Horst D, Sinn BV, Taube ET
Hum Pathol 2023 Nov;141:158-168. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.001. PMID: 37742945
Clinicopathological prognostic parameters in patients with tubo-ovarian carcinoma effusions.
Davidson B, Elstrand MB
Cytopathology 2022 Jul;33(4):479-492. Epub 2022 Apr 27 doi: 10.1111/cyt.13126. PMID: 35398934Free PMC Article
New therapeutic opportunities for women with low-grade serous ovarian cancer.
Moujaber T, Balleine RL, Gao B, Madsen I, Harnett PR, DeFazio A
Endocr Relat Cancer 2021 Nov 11;29(1):R1-R16. doi: 10.1530/ERC-21-0191. PMID: 34636747
Long-term survival of high-grade primary peritoneal papillary serous adenocarcinoma: a case report and literature review.
Yuan J, He L, Han B, Li Y
World J Surg Oncol 2017 Apr 11;15(1):76. doi: 10.1186/s12957-017-1134-3. PMID: 28399919Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181

Clinical prediction guides

Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Clinicopathological prognostic parameters in patients with tubo-ovarian carcinoma effusions.
Davidson B, Elstrand MB
Cytopathology 2022 Jul;33(4):479-492. Epub 2022 Apr 27 doi: 10.1111/cyt.13126. PMID: 35398934Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Precursor lesions and prognostic factors in primary peritoneal serous carcinoma.
Lee S, Nelson G, Duan Q, Magliocco AM, Duggan MA
Int J Gynecol Pathol 2013 Nov;32(6):547-55. doi: 10.1097/PGP.0b013e31827f3fa8. PMID: 24071870

Recent systematic reviews

Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article

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