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Nephrotic Syndrome - Infrequently Relapsing

MedGen UID:
926141
•Concept ID:
C4288609
•
Disease or Syndrome

Definition

Nephrotic syndrome in which there is a relapse occurring less than twice in the first six months, or less than four times in a year. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome - Infrequently Relapsing

Professional guidelines

PubMed

Management strategy for idiopathic nehprotic syndrome in children.
Chiu MC
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008 Jan;33(1):1-7. PMID: 18245896
Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.
Neuhaus TJ, Fay J, Dillon MJ, Trompeter RS, Barratt TM
Arch Dis Child 1994 Dec;71(6):522-6. doi: 10.1136/adc.71.6.522. PMID: 7726612Free PMC Article
Management of nephrotic syndrome in childhood.
Melvin T, Bennett W
Drugs 1991 Jul;42(1):30-51. doi: 10.2165/00003495-199142010-00003. PMID: 1718684

Recent clinical studies

Etiology

Thyroid Hormone Level in Children with Nephrotic Syndrome.
Das K, Ali MA, Akter MM, Kabir MR, Sadika S, Momo FR, Dipu MR, Avik AD, Paul A, Noshin N
Mymensingh Med J 2023 Oct;32(4):1005-1008. PMID: 37777893
Factors Associated With Hypertension and Cardiovascular Parameters in Children With Infrequently Relapsing Nephrotic Syndrome.
Fathima T M, Saha A, Chopra S, Raj A, Bhatt DD, Yadav M
Indian Pediatr 2023 Jun 15;60(6):475-480. Epub 2023 Apr 20 PMID: 37211892
Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Clinical efficacy of mycophenolate mofetil versus levamisole therapy in frequently relapsing and steroid dependent childhood nephrotic syndrome - A retrospective comparative analysis.
Sharma S, Kalra S, Shukla S, Sharma P
Nephrology (Carlton) 2022 Sep;27(9):758-762. Epub 2022 Jun 26 doi: 10.1111/nep.14067. PMID: 35619554
Remission and Relapses in Children with Steroid Sensitive Nephrotic Syndrome in Umuahia, South East Nigeria.
Ibeneme CA, Onuh EF, Ezuruike EO
West Afr J Med 2020 Oct;37(5):548-554. PMID: 33058131

Diagnosis

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Clinical efficacy of mycophenolate mofetil versus levamisole therapy in frequently relapsing and steroid dependent childhood nephrotic syndrome - A retrospective comparative analysis.
Sharma S, Kalra S, Shukla S, Sharma P
Nephrology (Carlton) 2022 Sep;27(9):758-762. Epub 2022 Jun 26 doi: 10.1111/nep.14067. PMID: 35619554
Remission and Relapses in Children with Steroid Sensitive Nephrotic Syndrome in Umuahia, South East Nigeria.
Ibeneme CA, Onuh EF, Ezuruike EO
West Afr J Med 2020 Oct;37(5):548-554. PMID: 33058131
Hypertension and its severity in children with steroid sensitive nephrotic syndrome during remission.
Keshri S, Sharma S, Agrawal N, Bansal S, Guilliani BP, Aggrawal KC
Clin Exp Nephrol 2018 Oct;22(5):1157-1162. Epub 2018 Mar 22 doi: 10.1007/s10157-018-1565-3. PMID: 29569147

Therapy

Risk Factors for Relapse in Childhood Nephrotic Syndrome.
Musharraf M, Majumder BK, Chowdhury RB, Mondal AR, Albani SA, Mostakim MA
Mymensingh Med J 2023 Oct;32(4):1091-1095. PMID: 37777906
Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Clinical efficacy of mycophenolate mofetil versus levamisole therapy in frequently relapsing and steroid dependent childhood nephrotic syndrome - A retrospective comparative analysis.
Sharma S, Kalra S, Shukla S, Sharma P
Nephrology (Carlton) 2022 Sep;27(9):758-762. Epub 2022 Jun 26 doi: 10.1111/nep.14067. PMID: 35619554
Short-Duration Prednisolone in Children with Nephrotic Syndrome Relapse: A Noninferiority Randomized Controlled Trial.
Kainth D, Hari P, Sinha A, Pandey S, Bagga A
Clin J Am Soc Nephrol 2021 Feb 8;16(2):225-232. Epub 2021 Jan 21 doi: 10.2215/CJN.06140420. PMID: 33478976Free PMC Article
Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome.
Chen HX, Cheng Q, Li F, He QN, Cao Y, Yi ZW, Wu XC
World J Pediatr 2020 Apr;16(2):159-167. Epub 2019 May 2 doi: 10.1007/s12519-019-00257-z. PMID: 31049814

Prognosis

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Clinical efficacy of mycophenolate mofetil versus levamisole therapy in frequently relapsing and steroid dependent childhood nephrotic syndrome - A retrospective comparative analysis.
Sharma S, Kalra S, Shukla S, Sharma P
Nephrology (Carlton) 2022 Sep;27(9):758-762. Epub 2022 Jun 26 doi: 10.1111/nep.14067. PMID: 35619554
Remission and Relapses in Children with Steroid Sensitive Nephrotic Syndrome in Umuahia, South East Nigeria.
Ibeneme CA, Onuh EF, Ezuruike EO
West Afr J Med 2020 Oct;37(5):548-554. PMID: 33058131
Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome.
Colucci M, Carsetti R, Rosado MM, Cascioli S, Bruschi M, Candiano G, Corpetti G, Giardino L, Serafinelli J, Giannone C, Ghiggeri GM, Rastaldi MP, Sitia R, Emma F, Vivarelli M
Kidney Int 2019 Oct;96(4):971-982. Epub 2019 May 7 doi: 10.1016/j.kint.2019.04.006. PMID: 31285081
Endothelial dysfuntion in children with idiopathic nephrotic syndrome.
Sharma B, Saha A, Dubey NK, Kapoor K, Anubhuti, Batra VV, Upadhayay AD
Atherosclerosis 2014 Apr;233(2):704-706. Epub 2014 Feb 11 doi: 10.1016/j.atherosclerosis.2014.01.055. PMID: 24583419

Clinical prediction guides

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Factors Associated With Hypertension and Cardiovascular Parameters in Children With Infrequently Relapsing Nephrotic Syndrome.
Fathima T M, Saha A, Chopra S, Raj A, Bhatt DD, Yadav M
Indian Pediatr 2023 Jun 15;60(6):475-480. Epub 2023 Apr 20 PMID: 37211892
Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome.
Chen HX, Cheng Q, Li F, He QN, Cao Y, Yi ZW, Wu XC
World J Pediatr 2020 Apr;16(2):159-167. Epub 2019 May 2 doi: 10.1007/s12519-019-00257-z. PMID: 31049814
Bone mineral density in children with relapsing nephrotic syndrome: A hospital-based study.
Jesmin T, Al Mamun A, Rahman MA, Santa SM, Huque SS, Begum A, Roy RR, Rahman MH, Uddin GM
Saudi J Kidney Dis Transpl 2019 Nov-Dec;30(6):1415-1422. doi: 10.4103/1319-2442.275486. PMID: 31929289
Prediction of Risk Factors of Frequent Relapse Idiopathic Nephrotic Syndrome.
Jahan I, Hanif M, Ali MA, Hoque MM
Mymensingh Med J 2015 Oct;24(4):735-42. PMID: 26620012

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