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Endometrial Dedifferentiated Carcinoma

MedGen UID:
927121
•Concept ID:
C4289589
•
Neoplastic Process

Definition

A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma. [from NCI]

Professional guidelines

PubMed

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
Treatment and outcomes in undifferentiated and dedifferentiated endometrial carcinoma.
Hamilton SN, Tinker AV, Kwon J, Lim P, Kong I, Sihra S, Koebel M, Lee CH
J Gynecol Oncol 2022 May;33(3):e25. Epub 2022 Jan 24 doi: 10.3802/jgo.2022.33.e25. PMID: 35128856Free PMC Article
Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.
Rabban JT, Gilks CB, Malpica A, Matias-Guiu X, Mittal K, Mutter GL, Oliva E, Parkash V, Ronnett BM, Staats P, Stewart CJR, McCluggage WG
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S25-S39. doi: 10.1097/PGP.0000000000000512. PMID: 30550482Free PMC Article

Recent clinical studies

Diagnosis

Molecular Evaluation of Endometrial Dedifferentiated Carcinoma, Endometrioid Carcinoma, Carcinosarcoma, and Serous Carcinoma Using a Custom-Made Small Cancer Panel.
Kobayashi Y, Kitazono I, Akahane T, Yanazume S, Kamio M, Togami S, Nohara S, Sakamoto I, Yokoyama S, Tabata K, Kobayashi H, Tanimoto A
Pathol Oncol Res 2021;27:1610013. Epub 2021 Dec 23 doi: 10.3389/pore.2021.1610013. PMID: 35002543Free PMC Article
Dedifferentiated carcinoma with clear cell carcinoma of the endometrium: A case report.
Lee SE, Park HY, Shim SH, Kim WY
Pathol Int 2017 Sep;67(9):472-476. Epub 2017 Jun 30 doi: 10.1111/pin.12557. PMID: 28667682

Prognosis

A novel case of endometrial dedifferentiated adenocarcinoma associated with MLH1 promotor hypermethylation and microsatellite instability.
Liu X, Liu X, Wang X, Wu R, Zhang K, Liu B, Liu Q, Shao Y, Tang R, You J, Pei F
Pathol Res Pract 2018 Nov;214(11):1904-1908. Epub 2018 Aug 20 doi: 10.1016/j.prp.2018.08.015. PMID: 30173944

Clinical prediction guides

Molecular Evaluation of Endometrial Dedifferentiated Carcinoma, Endometrioid Carcinoma, Carcinosarcoma, and Serous Carcinoma Using a Custom-Made Small Cancer Panel.
Kobayashi Y, Kitazono I, Akahane T, Yanazume S, Kamio M, Togami S, Nohara S, Sakamoto I, Yokoyama S, Tabata K, Kobayashi H, Tanimoto A
Pathol Oncol Res 2021;27:1610013. Epub 2021 Dec 23 doi: 10.3389/pore.2021.1610013. PMID: 35002543Free PMC Article
A novel case of endometrial dedifferentiated adenocarcinoma associated with MLH1 promotor hypermethylation and microsatellite instability.
Liu X, Liu X, Wang X, Wu R, Zhang K, Liu B, Liu Q, Shao Y, Tang R, You J, Pei F
Pathol Res Pract 2018 Nov;214(11):1904-1908. Epub 2018 Aug 20 doi: 10.1016/j.prp.2018.08.015. PMID: 30173944
Dedifferentiated carcinoma with clear cell carcinoma of the endometrium: A case report.
Lee SE, Park HY, Shim SH, Kim WY
Pathol Int 2017 Sep;67(9):472-476. Epub 2017 Jun 30 doi: 10.1111/pin.12557. PMID: 28667682

Supplemental Content

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