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Diffuse Midline Glioma, H3 K27M-Mutant

MedGen UID:
927220
Concept ID:
C4289688
Neoplastic Process
Synonyms: Diffuse midline glioma, H3 K27M-mutant; Diffuse midline glioma, point mutation K27M in histone H3
SNOMED CT: Diffuse midline glioma, point mutation K27M in histone H3 (733862004); Diffuse midline glioma, H3 K27M-mutant (733862004)

Definition

A diffuse midline glioma characterized by the presence of histone H3 K27M mutation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Midline Glioma, H3 K27M-Mutant

Professional guidelines

PubMed

van den Bent M, Saratsis AM, Geurts M, Franceschi E
Neuro Oncol 2024 May 3;26(Supplement_2):S110-S124. doi: 10.1093/neuonc/noad220. PMID: 38102230Free PMC Article
Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM
Neuro Oncol 2021 Mar 25;23(3):376-386. doi: 10.1093/neuonc/noaa249. PMID: 33130903Free PMC Article

Recent clinical studies

Etiology

Zheng L, Gong J, Yu T, Zou Y, Zhang M, Nie L, Chen X, Yue Q, Liu Y, Mao Q, Zhou Q, Chen N
Am J Surg Pathol 2022 Jun 1;46(6):863-871. Epub 2022 Apr 13 doi: 10.1097/PAS.0000000000001897. PMID: 35416795Free PMC Article
Banan R, Akbarian A, Samii M, Samii A, Bertalanffy H, Lehmann U, Hartmann C, Brüning R
PLoS One 2021;16(8):e0249647. Epub 2021 Aug 4 doi: 10.1371/journal.pone.0249647. PMID: 34347774Free PMC Article
Stephens S, Tollesson G, Robertson T, Campbell R
J Clin Neurosci 2019 Sep;67:288-293. Epub 2019 Jun 29 doi: 10.1016/j.jocn.2019.06.043. PMID: 31266714
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA
Acta Neuropathol 2015 Dec;130(6):815-27. Epub 2015 Sep 23 doi: 10.1007/s00401-015-1478-0. PMID: 26399631Free PMC Article

Diagnosis

Wang YZ, Zhang YW, Liu WH, Chai RC, Cao R, Wang B, An SY, Jiang WJ, Xu YL, Yang J, Jia WQ
Neurosurgery 2021 Jul 15;89(2):300-307. doi: 10.1093/neuros/nyab174. PMID: 34015818
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Alzoubi H, Maraqa B, Hasasna N, Giangaspero F, Antonelli M, Gianno F, Arcella A, Al-Hussaini M
Clin Neuropathol 2021 Mar-Apr;40(2):108-117. doi: 10.5414/NP301331. PMID: 33191898
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW
Acta Neuropathol 2016 Jun;131(6):803-20. Epub 2016 May 9 doi: 10.1007/s00401-016-1545-1. PMID: 27157931

Therapy

Cooney TM, Lubanszky E, Prasad R, Hawkins C, Mueller S
J Neurooncol 2020 Oct;150(1):27-34. Epub 2020 Aug 17 doi: 10.1007/s11060-020-03553-1. PMID: 32804378
Stephens S, Tollesson G, Robertson T, Campbell R
J Clin Neurosci 2019 Sep;67:288-293. Epub 2019 Jun 29 doi: 10.1016/j.jocn.2019.06.043. PMID: 31266714

Prognosis

Wang YZ, Zhang YW, Liu WH, Chai RC, Cao R, Wang B, An SY, Jiang WJ, Xu YL, Yang J, Jia WQ
Neurosurgery 2021 Jul 15;89(2):300-307. doi: 10.1093/neuros/nyab174. PMID: 34015818
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Alzoubi H, Maraqa B, Hasasna N, Giangaspero F, Antonelli M, Gianno F, Arcella A, Al-Hussaini M
Clin Neuropathol 2021 Mar-Apr;40(2):108-117. doi: 10.5414/NP301331. PMID: 33191898
Vaubel RA, Tian S, Remonde D, Schroeder MA, Mladek AC, Kitange GJ, Caron A, Kollmeyer TM, Grove R, Peng S, Carlson BL, Ma DJ, Sarkar G, Evers L, Decker PA, Yan H, Dhruv HD, Berens ME, Wang Q, Marin BM, Klee EW, Califano A, LaChance DH, Eckel-Passow JE, Verhaak RG, Sulman EP, Burns TC, Meyer FB, O'Neill BP, Tran NL, Giannini C, Jenkins RB, Parney IF, Sarkaria JN
Clin Cancer Res 2020 Mar 1;26(5):1094-1104. Epub 2019 Dec 18 doi: 10.1158/1078-0432.CCR-19-0909. PMID: 31852831Free PMC Article
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742

Clinical prediction guides

Wang YZ, Zhang YW, Liu WH, Chai RC, Cao R, Wang B, An SY, Jiang WJ, Xu YL, Yang J, Jia WQ
Neurosurgery 2021 Jul 15;89(2):300-307. doi: 10.1093/neuros/nyab174. PMID: 34015818
Sumi K, Shijo K, Igarashi T, Yamamuro S, Sasano M, Oshima H, Ishige T, Honma T, Yagasaki H, Yoshino A
World Neurosurg 2020 Sep;141:91-100. Epub 2020 Jun 4 doi: 10.1016/j.wneu.2020.05.240. PMID: 32505657
Karremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M, Bison B, Claviez A, van Vuurden DG, von Bueren AO, Gessi M, Kühnle I, Hans VH, Benesch M, Sturm D, Kortmann RD, Waha A, Pietsch T, Kramm CM
Neuro Oncol 2018 Jan 10;20(1):123-131. doi: 10.1093/neuonc/nox149. PMID: 29016894Free PMC Article
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA
Acta Neuropathol 2015 Dec;130(6):815-27. Epub 2015 Sep 23 doi: 10.1007/s00401-015-1478-0. PMID: 26399631Free PMC Article

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