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Cusp Thickening Severity

MedGen UID:
927244
•Concept ID:
C4289712
•
Finding

Definition

The qualitative measurement of the severity of a thickening cardiac valve cusp. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCusp Thickening Severity

Recent clinical studies

Etiology

Histopathological maladaptive changes in the explanted human mitral leaflets correlate with changes in echocardiographic leaflet morphology and the severity of ischaemic mitral regurgitation.
Avila-Vanzzini N, Lancellotti P, Fernandez Calix LA, De León López W, Berrios-Bárcenas E, Aranda-Fraustro A, Jordan-Rios A, Herrera-Bello H, Rivera-Lara P, Arias-Godínez JA, Vannan MA
Eur Heart J Cardiovasc Imaging 2023 Feb 17;24(3):392-400. doi: 10.1093/ehjci/jeac050. PMID: 35348652
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Intraoperative transoesophageal echocardiographic diagnosis and successful management of mycotic aortitis and pseudoaneurysm.
Tan CO, Weinberg L, Pillai P, Fernandes J
BMJ Case Rep 2013 Nov 22;2013:200675. doi: 10.1136/bcr-2013-200675. PMID: 24273009Free PMC Article
Modes of failure in explanted mitroflow pericardial valves.
Butany J, Feng T, Luk A, Law K, Suri R, Nair V
Ann Thorac Surg 2011 Nov;92(5):1621-7. Epub 2011 Sep 23 doi: 10.1016/j.athoracsur.2011.06.092. PMID: 21944438

Diagnosis

Progression of Aortic Regurgitation After Different Repair Techniques for Congenital Aortic Valve Stenosis.
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Intraoperative transoesophageal echocardiographic diagnosis and successful management of mycotic aortitis and pseudoaneurysm.
Tan CO, Weinberg L, Pillai P, Fernandes J
BMJ Case Rep 2013 Nov 22;2013:200675. doi: 10.1136/bcr-2013-200675. PMID: 24273009Free PMC Article
Doppler and echocardiographic features of normal and dysfunctioning bioprosthetic valves.
Alam M, Rosman HS, Lakier JB, Kemp S, Khaja F, Hautamaki K, Magilligan DJ Jr, Stein PD
J Am Coll Cardiol 1987 Oct;10(4):851-8. doi: 10.1016/s0735-1097(87)80280-2. PMID: 3309005
Aortitis in ankylosing spondylitis: early detection of aortic root abnormalities with two dimensional echocardiography.
Tucker CR, Fowles RE, Calin A, Popp RL
Am J Cardiol 1982 Mar;49(4):680-6. doi: 10.1016/0002-9149(82)91946-4. PMID: 7064818
Aortic stenosis: echocardiographic cusp separation and surgical description of aortic valve in 22 patients.
Chang S, Clements S, Chang J
Am J Cardiol 1977 Apr;39(4):499-504. doi: 10.1016/s0002-9149(77)80157-4. PMID: 848433

Therapy

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Native-valve Enterococcus hirae endocarditis: a case report and review of the literature.
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Progression of Aortic Regurgitation After Different Repair Techniques for Congenital Aortic Valve Stenosis.
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Whipple's disease and the heart.
Khairy P, Graham AF
Can J Cardiol 1996 Sep;12(9):831-4. PMID: 8842137

Prognosis

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Native-valve Enterococcus hirae endocarditis: a case report and review of the literature.
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Intraoperative transoesophageal echocardiographic diagnosis and successful management of mycotic aortitis and pseudoaneurysm.
Tan CO, Weinberg L, Pillai P, Fernandes J
BMJ Case Rep 2013 Nov 22;2013:200675. doi: 10.1136/bcr-2013-200675. PMID: 24273009Free PMC Article
Echocardiographic and clinical characteristics of aortic regurgitation because of systemic vasculitis.
Song JK, Jeong YH, Kang DH, Song JM, Song H, Choo SJ, Lee JW, Song MG
J Am Soc Echocardiogr 2003 Aug;16(8):850-7. doi: 10.1067/S0894-7317(03)00406-1. PMID: 12878994

Clinical prediction guides

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Modes of failure in explanted mitroflow pericardial valves.
Butany J, Feng T, Luk A, Law K, Suri R, Nair V
Ann Thorac Surg 2011 Nov;92(5):1621-7. Epub 2011 Sep 23 doi: 10.1016/j.athoracsur.2011.06.092. PMID: 21944438
Transesophageal echocardiographic features of normal and dysfunctioning bioprosthetic valves.
Alam M, Serwin JB, Rosman HS, Polanco GA, Sun I, Silverman NA
Am Heart J 1991 Apr;121(4 Pt 1):1149-55. doi: 10.1016/0002-8703(91)90676-9. PMID: 2008838

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