U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Astrocytoma, IDH-mutant, grade 3

MedGen UID:
927513
Concept ID:
C4289981
Neoplastic Process
Synonyms: Anaplastic Astrocytoma, IDH-Mutant; Astrocytoma, IDH-Mutant, Grade 3; astrocytoma, IDH-mutant, grade 3; Astrocytoma, IDH-Mutant, Grade III
 
Monarch Initiative: MONDO:0956995

Definition

IDH-mutant astrocytoma characterized by the presence of increased mitotic activity and anaplastic features. [from NCI]

Professional guidelines

PubMed

Segura PP, Quintela NV, García MM, Del Barco Berrón S, Sarrió RG, Gómez JG, Castaño AG, Martín LMN, Rubio OG, Losada EP
Clin Transl Oncol 2023 Sep;25(9):2634-2646. Epub 2023 Aug 4 doi: 10.1007/s12094-023-03245-y. PMID: 37540408Free PMC Article

Recent clinical studies

Etiology

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Schaff LR, Kushnirsky M, Lin AL, Nandakumar S, Grommes C, Miller AM, Gavrilovic IT, Nolan C, Pentsova E, Mellinghoff IK, Kaley TJ
Neurology 2022 Oct 24;99(17):750-755. doi: 10.1212/WNL.0000000000201203. PMID: 35948444Free PMC Article
Yang X, Xing Z, She D, Lin Y, Zhang H, Su Y, Cao D
BMC Med Imaging 2022 May 29;22(1):105. doi: 10.1186/s12880-022-00832-3. PMID: 35644621Free PMC Article
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. PMID: 26824661Free PMC Article

Diagnosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S
J Natl Compr Canc Netw 2023 Jan;21(1):12-20. doi: 10.6004/jnccn.2023.0002. PMID: 36634606
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Dono A, Ballester LY, Primdahl D, Esquenazi Y, Bhatia A
Curr Oncol Rep 2021 Jan 25;23(2):20. doi: 10.1007/s11912-020-01006-6. PMID: 33492489

Therapy

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Weller J, Katzendobler S, Blobner J, Thiele F, Becker H, Quach S, Egensperger R, Niyazi M, Suchorska B, Thon N, Weller M, Tonn JC
J Neurooncol 2022 Oct;160(1):149-158. Epub 2022 Sep 16 doi: 10.1007/s11060-022-04128-y. PMID: 36112301Free PMC Article
Schaff LR, Kushnirsky M, Lin AL, Nandakumar S, Grommes C, Miller AM, Gavrilovic IT, Nolan C, Pentsova E, Mellinghoff IK, Kaley TJ
Neurology 2022 Oct 24;99(17):750-755. doi: 10.1212/WNL.0000000000201203. PMID: 35948444Free PMC Article
Jo J, Schiff D
Curr Treat Options Oncol 2022 Sep;23(9):1219-1232. Epub 2022 Aug 1 doi: 10.1007/s11864-022-01000-z. PMID: 35913658
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

Prognosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Yang X, Xing Z, She D, Lin Y, Zhang H, Su Y, Cao D
BMC Med Imaging 2022 May 29;22(1):105. doi: 10.1186/s12880-022-00832-3. PMID: 35644621Free PMC Article
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK
Mod Pathol 2021 Jul;34(7):1245-1260. Epub 2021 Mar 10 doi: 10.1038/s41379-021-00778-x. PMID: 33692446

Clinical prediction guides

Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Schaff LR, Kushnirsky M, Lin AL, Nandakumar S, Grommes C, Miller AM, Gavrilovic IT, Nolan C, Pentsova E, Mellinghoff IK, Kaley TJ
Neurology 2022 Oct 24;99(17):750-755. doi: 10.1212/WNL.0000000000201203. PMID: 35948444Free PMC Article
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK
Mod Pathol 2021 Jul;34(7):1245-1260. Epub 2021 Mar 10 doi: 10.1038/s41379-021-00778-x. PMID: 33692446
Röhrich M, Loktev A, Wefers AK, Altmann A, Paech D, Adeberg S, Windisch P, Hielscher T, Flechsig P, Floca R, Leitz D, Schuster JP, Huber PE, Debus J, von Deimling A, Lindner T, Haberkorn U
Eur J Nucl Med Mol Imaging 2019 Nov;46(12):2569-2580. Epub 2019 Aug 6 doi: 10.1007/s00259-019-04444-y. PMID: 31388723

Recent systematic reviews

Tesileanu CMS, Vallentgoed WR, French PJ, van den Bent MJ
Eur J Cancer 2022 Nov;175:214-223. Epub 2022 Sep 21 doi: 10.1016/j.ejca.2022.08.016. PMID: 36152406
Halasz LM, Attia A, Bradfield L, Brat DJ, Kirkpatrick JP, Laack NN, Lalani N, Lebow ES, Liu AK, Niemeier HM, Palmer JD, Peters KB, Sheehan J, Thomas RP, Vora SA, Wahl DR, Weiss SE, Yeboa DN, Zhong J, Shih HA
Pract Radiat Oncol 2022 Sep-Oct;12(5):370-386. Epub 2022 May 31 doi: 10.1016/j.prro.2022.05.004. PMID: 35902341
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...