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Liver kidney microsome type 1 antibody positivity

MedGen UID:
927586
•Concept ID:
C4293677
•
Laboratory or Test Result
Synonyms: Anti-liver kidney microsomal type 1 antibody positivity; Anti-LKM-1 positive; Anti-LKM1 antibody positivity; Anti-type I liver-kidney microsomal antibody positivity
 
HPO: HP:0030908

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver kidney microsome type 1 antibody positivity

Professional guidelines

PubMed

Diagnostic criteria of autoimmune hepatitis.
Liberal R, Grant CR, Longhi MS, Mieli-Vergani G, Vergani D
Autoimmun Rev 2014 Apr-May;13(4-5):435-40. Epub 2014 Jan 10 doi: 10.1016/j.autrev.2013.11.009. PMID: 24418295
Role of international criteria in the diagnosis of autoimmune hepatitis.
Abdollahi MR, Somi MH, Faraji E
World J Gastroenterol 2013 Jun 21;19(23):3629-33. doi: 10.3748/wjg.v19.i23.3629. PMID: 23801865Free PMC Article
Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: a nationwide, multicenter study.
Kim BH, Kim YJ, Jeong SH, Tak WY, Ahn SH, Lee YJ, Jung EU, Lee JI, Yeon JE, Hwang JS, Um SH, Seo YS, Kim YS, Song BC, Kim JH, Jung YK, Park CK, Kim KA, Min HJ, Cho EY, Lee ES, Kwon SY, Chae HB, Kim DJ, Shin SR
J Gastroenterol Hepatol 2013 Jan;28(1):128-34. doi: 10.1111/j.1440-1746.2012.07292.x. PMID: 23033899

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