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Spinal instability

MedGen UID:
96082
•Concept ID:
C0410648
•
Disease or Syndrome
SNOMED CT: Spinal instability (240220009)
 
HPO: HP:0005881

Conditions with this feature

Microcephaly-cervical spine fusion anomalies syndrome
MedGen UID:
208663
•Concept ID:
C0796066
•
Disease or Syndrome
A very rare disorder, features include microcephaly, facial dysmorphism (beaked nose, low-set ears, downslanting palpebral fissures, micrognathia), mild intellectual deficit, short stature, and cervical spine fusion anomalies producing spinal cord compression.
See: Condition Record
Microcephaly-cervical spine fusion anomalies syndrome

Professional guidelines

PubMed

Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Spondylodiscitis: Diagnosis and Treatment Options.
Herren C, Jung N, Pishnamaz M, Breuninger M, Siewe J, Sobottke R
Dtsch Arztebl Int 2017 Dec 25;114(51-52):875-882. doi: 10.3238/arztebl.2017.0875. PMID: 29321098Free PMC Article
Diagnosis and Treatment Options of Spinal Metastases.
Barragán-Campos HM, Jiménez-Zarazúa O, Mondragón JD
Rev Invest Clin 2015 May-Jun;67(3):140-57. PMID: 26202738

Recent clinical studies

Etiology

Instability and impending instability in patients with vertebral metastatic disease.
Leone A, Cianfoni A, Zecchi V, Cortese MC, Rumi N, Colosimo C
Skeletal Radiol 2019 Feb;48(2):195-207. Epub 2018 Aug 1 doi: 10.1007/s00256-018-3032-3. PMID: 30069584
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Spondylodiscitis: Diagnosis and Treatment Options.
Herren C, Jung N, Pishnamaz M, Breuninger M, Siewe J, Sobottke R
Dtsch Arztebl Int 2017 Dec 25;114(51-52):875-882. doi: 10.3238/arztebl.2017.0875. PMID: 29321098Free PMC Article
Spinal stenosis.
Melancia JL, Francisco AF, Antunes JL
Handb Clin Neurol 2014;119:541-9. doi: 10.1016/B978-0-7020-4086-3.00035-7. PMID: 24365318
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

Diagnosis

Spondylodiscitis: Diagnosis and Treatment Options.
Herren C, Jung N, Pishnamaz M, Breuninger M, Siewe J, Sobottke R
Dtsch Arztebl Int 2017 Dec 25;114(51-52):875-882. doi: 10.3238/arztebl.2017.0875. PMID: 29321098Free PMC Article
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521
Neurotraumatology.
Perry EC 3rd, Ahmed HM, Origitano TC
Handb Clin Neurol 2014;121:1751-72. doi: 10.1016/B978-0-7020-4088-7.00113-9. PMID: 24365445
Spinal stenosis.
Melancia JL, Francisco AF, Antunes JL
Handb Clin Neurol 2014;119:541-9. doi: 10.1016/B978-0-7020-4086-3.00035-7. PMID: 24365318
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

Therapy

Endoscopic treatment of spondylodiscitis: systematic review.
Abreu PGP, Lourenço JA, Romero C, D Almeida GN, Pappamikail L, Lopes MF, Brito M, Teles P, Correia JP
Eur Spine J 2022 Jul;31(7):1765-1774. Epub 2022 Feb 24 doi: 10.1007/s00586-022-07142-w. PMID: 35211807
Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial.
Sahgal A, Myrehaug SD, Siva S, Masucci GL, Maralani PJ, Brundage M, Butler J, Chow E, Fehlings MG, Foote M, Gabos Z, Greenspoon J, Kerba M, Lee Y, Liu M, Liu SK, Thibault I, Wong RK, Hum M, Ding K, Parulekar WR; trial investigators
Lancet Oncol 2021 Jul;22(7):1023-1033. Epub 2021 Jun 11 doi: 10.1016/S1470-2045(21)00196-0. PMID: 34126044
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Pyogenic spondylodiscitis: an overview.
Skaf GS, Domloj NT, Fehlings MG, Bouclaous CH, Sabbagh AS, Kanafani ZA, Kanj SS
J Infect Public Health 2010;3(1):5-16. Epub 2010 Feb 19 doi: 10.1016/j.jiph.2010.01.001. PMID: 20701886
External spinal orthotics.
Sypert GW
Neurosurgery 1987 Apr;20(4):642-9. doi: 10.1227/00006123-198704000-00026. PMID: 3295581

Prognosis

Instability and impending instability in patients with vertebral metastatic disease.
Leone A, Cianfoni A, Zecchi V, Cortese MC, Rumi N, Colosimo C
Skeletal Radiol 2019 Feb;48(2):195-207. Epub 2018 Aug 1 doi: 10.1007/s00256-018-3032-3. PMID: 30069584
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Spine Conditions: Lumbar Spinal Stenosis.
Trigg SD, Devilbiss Z
FP Essent 2017 Oct;461:21-25. PMID: 29019641
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

Clinical prediction guides

Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial.
Sahgal A, Myrehaug SD, Siva S, Masucci GL, Maralani PJ, Brundage M, Butler J, Chow E, Fehlings MG, Foote M, Gabos Z, Greenspoon J, Kerba M, Lee Y, Liu M, Liu SK, Thibault I, Wong RK, Hum M, Ding K, Parulekar WR; trial investigators
Lancet Oncol 2021 Jul;22(7):1023-1033. Epub 2021 Jun 11 doi: 10.1016/S1470-2045(21)00196-0. PMID: 34126044
Spine Oncology: Imaging and Intervention.
Gibbs WN, Nael K, Doshi AH, Tanenbaum LN
Radiol Clin North Am 2019 Mar;57(2):377-395. Epub 2018 Dec 10 doi: 10.1016/j.rcl.2018.10.002. PMID: 30709476
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Spinal neoplastic instability: biomechanics and current management options.
Filis AK, Aghayev KV, Doulgeris JJ, Gonzalez-Blohm SA, Vrionis FD
Cancer Control 2014 Apr;21(2):144-50. doi: 10.1177/107327481402100207. PMID: 24667401
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

Recent systematic reviews

Postoperative spinal deformity and instability after cervical spinal cord tumor resection in adults: A systematic review and meta-analysis.
Noh SH, Takahashi T, Inoue T, Park SM, Hanakita J, Minami M, Kanematsu R, Shimauchi-Ohtaki H, Ha Y
J Clin Neurosci 2022 Jun;100:148-154. Epub 2022 Apr 23 doi: 10.1016/j.jocn.2022.04.005. PMID: 35472680
Endoscopic treatment of spondylodiscitis: systematic review.
Abreu PGP, Lourenço JA, Romero C, D Almeida GN, Pappamikail L, Lopes MF, Brito M, Teles P, Correia JP
Eur Spine J 2022 Jul;31(7):1765-1774. Epub 2022 Feb 24 doi: 10.1007/s00586-022-07142-w. PMID: 35211807
The Spinal Instability Neoplastic Score: Impact on Oncologic Decision-Making.
Versteeg AL, Verlaan JJ, Sahgal A, Mendel E, Quraishi NA, Fourney DR, Fisher CG
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S231-S237. doi: 10.1097/BRS.0000000000001822. PMID: 27488297
Positioning and spinal bracing for pain relief in metastatic spinal cord compression in adults.
Lee SH, Grant R, Kennedy C, Kilbride L
Cochrane Database Syst Rev 2015 Sep 24;2015(9):CD007609. doi: 10.1002/14651858.CD007609.pub3. PMID: 26400848Free PMC Article
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

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