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Atypical Meningioma

MedGen UID:
96558
•Concept ID:
C0431122
•
Neoplastic Process
Synonym: Atypical meningioma
SNOMED CT: Atypical meningioma (128914005)

Definition

A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Meningioma

Professional guidelines

PubMed

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388
Atypical meningoma: current management dilemmas and prospective clinical trials.
Jenkinson MD, Weber DC, Haylock BJ, Mallucci CL, Zakaria R, Javadpour M
J Neurooncol 2015 Jan;121(1):1-7. Epub 2014 Sep 26 doi: 10.1007/s11060-014-1620-1. PMID: 25258253

Recent clinical studies

Etiology

Differentiating atypical meningioma from anaplastic meningioma using diffusion weighted imaging.
Han T, Zhang J, Liu X, Zhang B, Deng L, Lin X, Jing M, Zhou J
Clin Imaging 2022 Feb;82:237-243. Epub 2021 Dec 11 doi: 10.1016/j.clinimag.2021.12.004. PMID: 34915318
Atypical meningioma: patterns of postradiotherapy recurrences.
Schuring-Pereira M, Hagenbeek R, Mast M, Nandoe Tewarie R, van Santvoort JPC, van Duinen S, Wiggenraad R
Br J Neurosurg 2021 Oct;35(5):591-596. Epub 2021 Jun 1 doi: 10.1080/02688697.2021.1922606. PMID: 34074192
Current experimental therapies for atypical and malignant meningiomas.
Corona AM, Di L, Shah AH, Crespo R, Eichberg DG, Lu VM, Luther EM, Komotar RJ, Ivan ME
J Neurooncol 2021 Jun;153(2):203-210. Epub 2021 May 5 doi: 10.1007/s11060-021-03759-x. PMID: 33950341
Pathology of meningiomas.
Solomon DA, Pekmezci M
Handb Clin Neurol 2020;169:87-99. doi: 10.1016/B978-0-12-804280-9.00005-6. PMID: 32553300
Bevacizumab in refractory higher-grade and atypical meningioma: the current state of affairs.
Dasanu CA, Alvarez-Argote J, Limonadi FM, Codreanu I
Expert Opin Biol Ther 2019 Feb;19(2):99-104. Epub 2018 Dec 17 doi: 10.1080/14712598.2019.1559292. PMID: 30556741

Diagnosis

Differentiating atypical meningioma from anaplastic meningioma using diffusion weighted imaging.
Han T, Zhang J, Liu X, Zhang B, Deng L, Lin X, Jing M, Zhou J
Clin Imaging 2022 Feb;82:237-243. Epub 2021 Dec 11 doi: 10.1016/j.clinimag.2021.12.004. PMID: 34915318
The histopathological diagnosis of atypical meningioma: glass slide versus whole slide imaging for grading assessment.
Ammendola S, Bariani E, Eccher A, Capitanio A, Ghimenton C, Pantanowitz L, Parwani A, Girolami I, Scarpa A, Barresi V
Virchows Arch 2021 Apr;478(4):747-756. Epub 2020 Dec 10 doi: 10.1007/s00428-020-02988-1. PMID: 33305338Free PMC Article
Atypical meningiomas.
Chen R, Aghi MK
Handb Clin Neurol 2020;170:233-244. doi: 10.1016/B978-0-12-822198-3.00043-4. PMID: 32586495
Differentiating microcystic meningioma from atypical meningioma using diffusion-weighted imaging.
Xiaoai K, Qing Z, Lei H, Junlin Z
Neuroradiology 2020 May;62(5):601-607. Epub 2020 Jan 29 doi: 10.1007/s00234-020-02374-3. PMID: 31996968
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW
Acta Neuropathol 2016 Jun;131(6):803-20. Epub 2016 May 9 doi: 10.1007/s00401-016-1545-1. PMID: 27157931

Therapy

Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Atypical meningioma: patterns of postradiotherapy recurrences.
Schuring-Pereira M, Hagenbeek R, Mast M, Nandoe Tewarie R, van Santvoort JPC, van Duinen S, Wiggenraad R
Br J Neurosurg 2021 Oct;35(5):591-596. Epub 2021 Jun 1 doi: 10.1080/02688697.2021.1922606. PMID: 34074192
Pharmacotherapeutic options for atypical meningiomas.
Ahsan SA, Chendeb K, Profyris C, Teo C, Sughrue ME
Expert Opin Pharmacother 2019 Oct;20(15):1831-1836. Epub 2019 Jul 19 doi: 10.1080/14656566.2019.1643840. PMID: 31322413
Bevacizumab in refractory higher-grade and atypical meningioma: the current state of affairs.
Dasanu CA, Alvarez-Argote J, Limonadi FM, Codreanu I
Expert Opin Biol Ther 2019 Feb;19(2):99-104. Epub 2018 Dec 17 doi: 10.1080/14712598.2019.1559292. PMID: 30556741
Salvage therapy outcomes for atypical meningioma.
Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE
J Neurooncol 2018 Jun;138(2):425-433. Epub 2018 Feb 26 doi: 10.1007/s11060-018-2813-9. PMID: 29480505

Prognosis

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Atypical meningioma: patterns of postradiotherapy recurrences.
Schuring-Pereira M, Hagenbeek R, Mast M, Nandoe Tewarie R, van Santvoort JPC, van Duinen S, Wiggenraad R
Br J Neurosurg 2021 Oct;35(5):591-596. Epub 2021 Jun 1 doi: 10.1080/02688697.2021.1922606. PMID: 34074192
Current experimental therapies for atypical and malignant meningiomas.
Corona AM, Di L, Shah AH, Crespo R, Eichberg DG, Lu VM, Luther EM, Komotar RJ, Ivan ME
J Neurooncol 2021 Jun;153(2):203-210. Epub 2021 May 5 doi: 10.1007/s11060-021-03759-x. PMID: 33950341
Differentiating microcystic meningioma from atypical meningioma using diffusion-weighted imaging.
Xiaoai K, Qing Z, Lei H, Junlin Z
Neuroradiology 2020 May;62(5):601-607. Epub 2020 Jan 29 doi: 10.1007/s00234-020-02374-3. PMID: 31996968
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388

Clinical prediction guides

Atypical meningioma: Histopathological, genetic, and epigenetic features to predict recurrence risk.
Marastoni E, Barresi V
Histol Histopathol 2024 Mar;39(3):293-302. Epub 2023 Oct 20 doi: 10.14670/HH-18-670. PMID: 37921468
Discrimination between microcystic meningioma and atypical meningioma using whole-lesion apparent diffusion coefficient histogram analysis.
Liu X, Huang X, Han T, Li S, Xue C, Deng J, Zhou Q, Sun Q, Zhou J
Clin Radiol 2022 Nov;77(11):864-869. Epub 2022 Aug 25 doi: 10.1016/j.crad.2022.07.004. PMID: 36030110
Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Mitotic Index and Progression-Free Survival in Atypical Meningiomas.
Domingo RA, Tripathi S, Vivas-Buitrago T, Lu VM, Chaichana KL, Quiñones-Hinojosa A
World Neurosurg 2020 Oct;142:191-196. Epub 2020 Jun 29 doi: 10.1016/j.wneu.2020.06.189. PMID: 32615290
Differentiating microcystic meningioma from atypical meningioma using diffusion-weighted imaging.
Xiaoai K, Qing Z, Lei H, Junlin Z
Neuroradiology 2020 May;62(5):601-607. Epub 2020 Jan 29 doi: 10.1007/s00234-020-02374-3. PMID: 31996968

Recent systematic reviews

Should adjuvant radiotherapy be used in atypical meningioma (WHO grade 2) following gross total resection? A systematic review and Meta-analysis.
Wujanto C, Chan TY, Soon YY, Vellayappan B
Acta Oncol 2022 Sep;61(9):1075-1083. Epub 2022 Sep 2 doi: 10.1080/0284186X.2022.2116994. PMID: 36052871
Adjuvant radiotherapy versus observation following gross total resection for atypical meningioma: a systematic review and meta-analysis.
Chun SW, Kim KM, Kim MS, Kang H, Dho YS, Seo Y, Kim JW, Kim YH, Park CK
Radiat Oncol 2021 Feb 17;16(1):34. doi: 10.1186/s13014-021-01759-9. PMID: 33596974Free PMC Article
Association of Race with Survival in Intracranial World Health Organization Grade II and III Meningioma in the United States: Systematic Literature Review.
Elder T, Ejikeme T, Felton P, Raghavan A, Wright J, Wright CH, Zhou X, Duncan K, Sajatovic M, Hodges T
World Neurosurg 2020 Jun;138:e361-e369. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.02.120. PMID: 32142947
A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas.
Coggins WS, Pham NK, Nguyen AV, Branch DW, Guillet JY, Korst G, Lall RR
World Neurosurg 2019 Dec;132:282-291. Epub 2019 Aug 30 doi: 10.1016/j.wneu.2019.08.149. PMID: 31476452
Adjuvant radiotherapy for atypical and malignant meningiomas: a systematic review.
Kaur G, Sayegh ET, Larson A, Bloch O, Madden M, Sun MZ, Barani IJ, James CD, Parsa AT
Neuro Oncol 2014 May;16(5):628-36. Epub 2014 Apr 2 doi: 10.1093/neuonc/nou025. PMID: 24696499Free PMC Article

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