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Pulmonary vascular resistance

MedGen UID:
96817
Concept ID:
C0456261
Finding
Synonyms: Pulmonary Vascular Resistance; Resistance, Pulmonary Vascular; Vascular Resistance, Pulmonary
SNOMED CT: PVR - Pulmonary vascular resistance (276901002); Pulmonary vascular resistance (276901002)

Definition

The resistance to blood flow offered by the pulmonary vasculature, which is normally one sixth of SVR. The major determinant of PVR is pulmonary vessel constriction, most often caused by hypoxia and/or hypercarbia. Prolonged elevated PVR can cause right heart failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary vascular resistance

Professional guidelines

PubMed

Ruopp NF, Cockrill BA
JAMA 2022 Apr 12;327(14):1379-1391. doi: 10.1001/jama.2022.4402. PMID: 35412560
Singh Y, Lakshminrusimha S
Clin Perinatol 2021 Aug;48(3):595-618. doi: 10.1016/j.clp.2021.05.009. PMID: 34353582Free PMC Article
Beshay S, Sahay S, Humbert M
Respir Med 2020 Sep;171:106099. Epub 2020 Aug 19 doi: 10.1016/j.rmed.2020.106099. PMID: 32829182

Recent clinical studies

Etiology

Jaïs X, Brenot P, Bouvaist H, Jevnikar M, Canuet M, Chabanne C, Chaouat A, Cottin V, De Groote P, Favrolt N, Horeau-Langlard D, Magro P, Savale L, Prévot G, Renard S, Sitbon O, Parent F, Trésorier R, Tromeur C, Piedvache C, Grimaldi L, Fadel E, Montani D, Humbert M, Simonneau G
Lancet Respir Med 2022 Oct;10(10):961-971. Epub 2022 Aug 1 doi: 10.1016/S2213-2600(22)00214-4. PMID: 35926542
Omote K, Sorimachi H, Obokata M, Reddy YNV, Verbrugge FH, Omar M, DuBrock HM, Redfield MM, Borlaug BA
Eur Heart J 2022 Sep 21;43(36):3417-3431. doi: 10.1093/eurheartj/ehac184. PMID: 35796488Free PMC Article
Luna-López R, Ruiz Martín A, Escribano Subías P
Med Clin (Barc) 2022 Jun 24;158(12):622-629. Epub 2022 Mar 9 doi: 10.1016/j.medcli.2022.01.003. PMID: 35279313
Anjum H, Surani S
Medicina (Kaunas) 2021 Mar 11;57(3) doi: 10.3390/medicina57030259. PMID: 33799910Free PMC Article
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641

Diagnosis

Luna-López R, Ruiz Martín A, Escribano Subías P
Med Clin (Barc) 2022 Jun 24;158(12):622-629. Epub 2022 Mar 9 doi: 10.1016/j.medcli.2022.01.003. PMID: 35279313
Beshay S, Sahay S, Humbert M
Respir Med 2020 Sep;171:106099. Epub 2020 Aug 19 doi: 10.1016/j.rmed.2020.106099. PMID: 32829182
Pascall E, Tulloh RM
Future Cardiol 2018 Jul;14(4):343-353. Epub 2018 May 24 doi: 10.2217/fca-2017-0065. PMID: 29792339Free PMC Article
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641
Duggan M, Kavanagh BP
Anesthesiology 2005 Apr;102(4):838-54. doi: 10.1097/00000542-200504000-00021. PMID: 15791115

Therapy

Hoeper MM, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, McLaughlin VV, Preston IR, Souza R, Waxman AB, Grünig E, Kopeć G, Meyer G, Olsson KM, Rosenkranz S, Xu Y, Miller B, Fowler M, Butler J, Koglin J, de Oliveira Pena J, Humbert M; STELLAR Trial Investigators
N Engl J Med 2023 Apr 20;388(16):1478-1490. Epub 2023 Mar 6 doi: 10.1056/NEJMoa2213558. PMID: 36877098
Zhang H, Wei Y, Zhang C, Yang Z, Kan J, Gu H, Fan F, Gu H, Wang Q, Xie D, Zhang G, Guo X, Yin Y, Jin B, Zhou H, Yang Z, Wang Z, Xin Y, Zhang C, Meng L, Wang X, Sun J, Zhao C, Zhang J, Yan X, Chen F, Yao C, Stone GW, Chen SL
JACC Cardiovasc Interv 2022 Dec 12;15(23):2412-2423. Epub 2022 Sep 18 doi: 10.1016/j.jcin.2022.09.013. PMID: 36121246
Jaïs X, Brenot P, Bouvaist H, Jevnikar M, Canuet M, Chabanne C, Chaouat A, Cottin V, De Groote P, Favrolt N, Horeau-Langlard D, Magro P, Savale L, Prévot G, Renard S, Sitbon O, Parent F, Trésorier R, Tromeur C, Piedvache C, Grimaldi L, Fadel E, Montani D, Humbert M, Simonneau G
Lancet Respir Med 2022 Oct;10(10):961-971. Epub 2022 Aug 1 doi: 10.1016/S2213-2600(22)00214-4. PMID: 35926542
Humbert M, McLaughlin V, Gibbs JSR, Gomberg-Maitland M, Hoeper MM, Preston IR, Souza R, Waxman A, Escribano Subias P, Feldman J, Meyer G, Montani D, Olsson KM, Manimaran S, Barnes J, Linde PG, de Oliveira Pena J, Badesch DB; PULSAR Trial Investigators
N Engl J Med 2021 Apr 1;384(13):1204-1215. doi: 10.1056/NEJMoa2024277. PMID: 33789009
Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ; PATENT-1 Study Group
N Engl J Med 2013 Jul 25;369(4):330-40. doi: 10.1056/NEJMoa1209655. PMID: 23883378

Prognosis

Jaïs X, Brenot P, Bouvaist H, Jevnikar M, Canuet M, Chabanne C, Chaouat A, Cottin V, De Groote P, Favrolt N, Horeau-Langlard D, Magro P, Savale L, Prévot G, Renard S, Sitbon O, Parent F, Trésorier R, Tromeur C, Piedvache C, Grimaldi L, Fadel E, Montani D, Humbert M, Simonneau G
Lancet Respir Med 2022 Oct;10(10):961-971. Epub 2022 Aug 1 doi: 10.1016/S2213-2600(22)00214-4. PMID: 35926542
Suzuki S, Asano R, Aoki T, Nakayama S, Ueda J, Tsuji A, Noguchi T, Ogo T
Open Heart 2022 Jun;9(1) doi: 10.1136/openhrt-2022-002054. PMID: 35675988Free PMC Article
Beshay S, Sahay S, Humbert M
Respir Med 2020 Sep;171:106099. Epub 2020 Aug 19 doi: 10.1016/j.rmed.2020.106099. PMID: 32829182
Ivy DD, Abman SH, Barst RJ, Berger RM, Bonnet D, Fleming TR, Haworth SG, Raj JU, Rosenzweig EB, Schulze Neick I, Steinhorn RH, Beghetti M
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D117-26. doi: 10.1016/j.jacc.2013.10.028. PMID: 24355636
Razuin R, Effat O, Shahidan MN, Shama DV, Miswan MF
Malays J Pathol 2013 Jun;35(1):87-90. PMID: 23817399

Clinical prediction guides

Jaïs X, Brenot P, Bouvaist H, Jevnikar M, Canuet M, Chabanne C, Chaouat A, Cottin V, De Groote P, Favrolt N, Horeau-Langlard D, Magro P, Savale L, Prévot G, Renard S, Sitbon O, Parent F, Trésorier R, Tromeur C, Piedvache C, Grimaldi L, Fadel E, Montani D, Humbert M, Simonneau G
Lancet Respir Med 2022 Oct;10(10):961-971. Epub 2022 Aug 1 doi: 10.1016/S2213-2600(22)00214-4. PMID: 35926542
DuBrock HM, Cartin-Ceba R, Channick RN, Kawut SM, Krowka MJ
Chest 2021 Jan;159(1):328-336. Epub 2020 Aug 13 doi: 10.1016/j.chest.2020.07.081. PMID: 32798521Free PMC Article
Kwan WC, Shavelle DM, Laughrun DR
Clin Cardiol 2019 Mar;42(3):334-338. Epub 2019 Feb 27 doi: 10.1002/clc.23151. PMID: 30614019Free PMC Article
Wright LM, Dwyer N, Celermajer D, Kritharides L, Marwick TH
JACC Cardiovasc Imaging 2016 Jun;9(6):733-46. doi: 10.1016/j.jcmg.2016.02.022. PMID: 27282440
Naeije R, D'Alto M, Forfia PR
Prog Cardiovasc Dis 2015 Mar-Apr;57(5):463-72. Epub 2014 Dec 19 doi: 10.1016/j.pcad.2014.12.003. PMID: 25534670

Recent systematic reviews

Yasuhara J, Watanabe K, Watanabe A, Shirasu T, Matsuzaki Y, Watanabe H, Takagi H, Sumitomo N, Kuno T
Cardiol Young 2023 Nov;33(11):2297-2311. Epub 2023 Feb 1 doi: 10.1017/S1047951123000124. PMID: 36721907
Kennedy MK, Kennedy SA, Tan KT, de Perrot M, Bassett P, McInnis MC, Thenganatt J, Donahoe L, Granton J, Mafeld S
Cardiovasc Intervent Radiol 2023 Jan;46(1):5-18. Epub 2022 Dec 6 doi: 10.1007/s00270-022-03323-8. PMID: 36474104
Wang L, Zhu L, Wu Y, Li Q, Liu H
Ann Palliat Med 2021 Oct;10(10):11117-11128. doi: 10.21037/apm-21-2656. PMID: 34763472
Price LC, Martinez G, Brame A, Pickworth T, Samaranayake C, Alexander D, Garfield B, Aw TC, McCabe C, Mukherjee B, Harries C, Kempny A, Gatzoulis M, Marino P, Kiely DG, Condliffe R, Howard L, Davies R, Coghlan G, Schreiber BE, Lordan J, Taboada D, Gaine S, Johnson M, Church C, Kemp SV, Wong D, Curry A, Levett D, Price S, Ledot S, Reed A, Dimopoulos K, Wort SJ
Br J Anaesth 2021 Apr;126(4):774-790. Epub 2021 Feb 19 doi: 10.1016/j.bja.2021.01.005. PMID: 33612249
Rahnavardi M, Yan TD, Cao C, Vallely MP, Bannon PG, Wilson MK
Ann Thorac Cardiovasc Surg 2011;17(5):435-45. Epub 2011 Jul 13 doi: 10.5761/atcs.oa.10.01653. PMID: 21881372

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