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Chondrogenic neoplasm

MedGen UID:
96904
•Concept ID:
C0476147
•
Neoplastic Process
Synonyms: Cartilaginous Neoplasm; cartilaginous neoplasm; Cartilaginous Tumor; cartilaginous tumor; cartilaginous tumour; Chondrogenic Neoplasm; chondrogenic neoplasm; Chondrogenic Tumor; chondrogenic tumor; chondrogenic tumour; Chondromatous Neoplasm; chondromatous neoplasm; Chondromatous Tumor; chondromatous tumor; chondromatous tumour; Neoplasm of Cartilage; neoplasm of cartilage; Neoplasm of the Cartilage; neoplasm of the cartilage; Tumor of Cartilage; tumor of cartilage; Tumor of the Cartilage; tumor of the cartilage; tumour of cartilage; tumour of the cartilage
 
Monarch Initiative: MONDO:0024469

Definition

A benign, intermediate, or malignant cartilaginous matrix-producing neoplasm. Representative examples include osteochondroma, chondroblastoma, and chondrosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondrogenic neoplasm

Professional guidelines

PubMed

Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review).
Cui X, Shang S, Lv X, Zhao J, Qi Y, Liu Z
Mol Med Rep 2019 Jun;19(6):5053-5062. Epub 2019 Apr 30 doi: 10.3892/mmr.2019.10209. PMID: 31059090Free PMC Article
Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.
Omlor GW, Lohnherr V, Lange J, Gantz S, Mechtersheimer G, Merle C, Raiss P, Fellenberg J, Lehner B
BMC Musculoskelet Disord 2019 Mar 28;20(1):134. doi: 10.1186/s12891-019-2502-7. PMID: 30922289Free PMC Article
The biology and management of cartilaginous tumors: a role for targeting isocitrate dehydrogenase.
Tinoco G, Wilky BA, Paz-Mejia A, Rosenberg A, Trent JC
Am Soc Clin Oncol Educ Book 2015:e648-55. doi: 10.14694/EdBook_AM.2015.35.e648. PMID: 25993236

Recent clinical studies

Etiology

Intra-Articular Tumors.
Sbaraglia M, Gambarotti M, Businello G, Righi A, Fassan M, Dei Tos AP
Surg Pathol Clin 2021 Dec;14(4):665-677. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.008. PMID: 34742486

Diagnosis

Intramuscular, extraskeletal mesenchymal chondrosarcoma.
Jain M, Puri V, Madan NK
Indian J Med Sci 2011 Dec;65(12):552-6. PMID: 23548257
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton.
Müller S, Söder S, Oliveira AM, Inwards CY, Aigner T
Mod Pathol 2005 Aug;18(8):1088-94. doi: 10.1038/modpathol.3800391. PMID: 15731776

Prognosis

Intramuscular, extraskeletal mesenchymal chondrosarcoma.
Jain M, Puri V, Madan NK
Indian J Med Sci 2011 Dec;65(12):552-6. PMID: 23548257
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation.
Nussbeck W, Neureiter D, Söder S, Inwards C, Aigner T
Pathology 2004 Jun;36(3):230-3. doi: 10.1080/00313020410001716669. PMID: 15203726

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