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Familial or sporadic hemiplegic migraine

MedGen UID:
977550
•Concept ID:
CN295307
•
Disease or Syndrome
Synonyms: familial or sporadic hemiplegic migraine; hemiplegic migraine; Hemiplegic Migraine
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
•Concept ID:
C0443147
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Autosomal dominant inheritance (Orphanet)
 
Related genes: SCN1A, CACNA1A, ATP1A2
 
Monarch Initiative: MONDO:0018925
Orphanet: ORPHA569

Definition

A rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. There are two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM). [from ORDO]

Professional guidelines

PubMed

Treatment of hemiplegic migraine with triptans.
Artto V, Nissilä M, Wessman M, Palotie A, Färkkilä M, Kallela M
Eur J Neurol 2007 Sep;14(9):1053-6. doi: 10.1111/j.1468-1331.2007.01900.x. PMID: 17718700

Recent clinical studies

Etiology

Family Adjustment to Hereditary Cancer Syndromes: A Systematic Review.
Gomes P, Pietrabissa G, Silva ER, Silva J, Matos PM, Costa ME, Bertuzzi V, Silva E, Neves MC, Sales CMD
Int J Environ Res Public Health 2022 Jan 30;19(3) doi: 10.3390/ijerph19031603. PMID: 35162625Free PMC Article
Familial associations between autoimmune hepatitis and primary biliary cholangitis and other autoimmune diseases.
Thomsen H, Li X, Sundquist K, Sundquist J, Försti A, Hemminki K
PLoS One 2020;15(10):e0240794. Epub 2020 Oct 20 doi: 10.1371/journal.pone.0240794. PMID: 33079961Free PMC Article
Molecular factors in migraine.
Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J
Oncotarget 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. PMID: 27191890Free PMC Article
Sporadic hemiplegic migraine.
Thomsen LL, Olesen J
Cephalalgia 2004 Dec;24(12):1016-23. doi: 10.1111/j.1468-2982.2004.00788.x. PMID: 15566415
Sporadic hemiplegic migraine.
Black DF
Curr Pain Headache Rep 2004 Jun;8(3):223-8. doi: 10.1007/s11916-004-0056-2. PMID: 15115642

Diagnosis

Hemiplegic migraine.
de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Hemiplegic Migraine.
Nandyala A, Shah T, Ailani J
Curr Neurol Neurosci Rep 2023 Jul;23(7):381-387. Epub 2023 May 29 doi: 10.1007/s11910-023-01277-z. PMID: 37247170
Diagnostic and therapeutic aspects of hemiplegic migraine.
Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
SCN1A-related phenotypes: Epilepsy and beyond.
Scheffer IE, Nabbout R
Epilepsia 2019 Dec;60 Suppl 3:S17-S24. doi: 10.1111/epi.16386. PMID: 31904117
Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.
Karst JS, Van Hecke AV
Clin Child Fam Psychol Rev 2012 Sep;15(3):247-77. doi: 10.1007/s10567-012-0119-6. PMID: 22869324

Therapy

Diagnostic and therapeutic aspects of hemiplegic migraine.
Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
Early intervention program for very low birth weight preterm infants and their parents: a study protocol.
Silveira RC, Mendes EW, Fuentefria RN, Valentini NC, Procianoy RS
BMC Pediatr 2018 Aug 9;18(1):268. doi: 10.1186/s12887-018-1240-6. PMID: 30092772Free PMC Article
Heart failure family-based education: a systematic review.
Srisuk N, Cameron J, Ski CF, Thompson DR
Patient Educ Couns 2016 Mar;99(3):326-338. Epub 2015 Oct 22 doi: 10.1016/j.pec.2015.10.009. PMID: 26519992
Management of sporadic and familial hemiplegic migraine.
Russell MB
Expert Rev Neurother 2010 Mar;10(3):381-7. doi: 10.1586/ern.09.127. PMID: 20187861
Eliminating bias in randomized controlled trials: importance of allocation concealment and masking.
Viera AJ, Bangdiwala SI
Fam Med 2007 Feb;39(2):132-7. PMID: 17273956

Prognosis

Hemiplegic migraine.
de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Familial aggregation of early-onset haematological malignancies.
Rönkkö R, Hirvonen E, Malila N, Kilpivaara O, Wartiovaara-Kautto U, Pitkäniemi J
Br J Haematol 2021 Jun;193(6):1134-1141. Epub 2021 May 18 doi: 10.1111/bjh.17477. PMID: 34002362
Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2.
Antonaci F, Ravaglia S, Grieco GS, Gagliardi S, Cereda C, Costa A
J Headache Pain 2021 Mar 12;22(1):12. doi: 10.1186/s10194-021-01221-x. PMID: 33711927Free PMC Article
Trajectories of childhood adversity and mortality in early adulthood: a population-based cohort study.
Rod NH, Bengtsson J, Budtz-Jørgensen E, Clipet-Jensen C, Taylor-Robinson D, Andersen AN, Dich N, Rieckmann A
Lancet 2020 Aug 15;396(10249):489-497. doi: 10.1016/S0140-6736(20)30621-8. PMID: 32798491
Early-life mortality clustering in families: A literature review.
van Dijk IK
Popul Stud (Camb) 2019 Mar;73(1):79-99. Epub 2018 May 4 doi: 10.1080/00324728.2018.1448434. PMID: 29726744

Clinical prediction guides

Hemiplegic migraine.
de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2.
Antonaci F, Ravaglia S, Grieco GS, Gagliardi S, Cereda C, Costa A
J Headache Pain 2021 Mar 12;22(1):12. doi: 10.1186/s10194-021-01221-x. PMID: 33711927Free PMC Article
Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation.
Pelzer N, Haan J, Stam AH, Vijfhuizen LS, Koelewijn SC, Smagge A, de Vries B, Ferrari MD, van den Maagdenberg AMJM, Terwindt GM
Neurology 2018 Feb 13;90(7):e575-e582. Epub 2018 Jan 17 doi: 10.1212/WNL.0000000000004966. PMID: 29343472
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications.
Prontera P, Sarchielli P, Caproni S, Bedetti C, Cupini LM, Calabresi P, Costa C
Cephalalgia 2018 Feb;38(2):361-373. Epub 2017 Jan 6 doi: 10.1177/0333102416686347. PMID: 28058944
Molecular factors in migraine.
Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J
Oncotarget 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. PMID: 27191890Free PMC Article

Recent systematic reviews

Delirium-related distress in the ICU: A qualitative meta-synthesis of patient and family perspectives and experiences.
Boehm LM, Jones AC, Selim AA, Virdun C, Garrard CF, Walden RL, Wesley Ely E, Hosie A
Int J Nurs Stud 2021 Oct;122:104030. Epub 2021 Jul 3 doi: 10.1016/j.ijnurstu.2021.104030. PMID: 34343884Free PMC Article
The Benefits and Burdens of Pediatric Palliative Care and End-of-Life Research: A Systematic Review.
Weaver MS, Mooney-Doyle K, Kelly KP, Montgomery K, Newman AR, Fortney CA, Bell CJ, Spruit JL, Kurtz Uveges M, Wiener L, Schmidt CM, Madrigal VN, Hinds PS
J Palliat Med 2019 Aug;22(8):915-926. Epub 2019 Mar 5 doi: 10.1089/jpm.2018.0483. PMID: 30835596Free PMC Article
Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU.
Davidson JE, Aslakson RA, Long AC, Puntillo KA, Kross EK, Hart J, Cox CE, Wunsch H, Wickline MA, Nunnally ME, Netzer G, Kentish-Barnes N, Sprung CL, Hartog CS, Coombs M, Gerritsen RT, Hopkins RO, Franck LS, Skrobik Y, Kon AA, Scruth EA, Harvey MA, Lewis-Newby M, White DB, Swoboda SM, Cooke CR, Levy MM, Azoulay E, Curtis JR
Crit Care Med 2017 Jan;45(1):103-128. doi: 10.1097/CCM.0000000000002169. PMID: 27984278
Surrogacy: outcomes for surrogate mothers, children and the resulting families-a systematic review.
Söderström-Anttila V, Wennerholm UB, Loft A, Pinborg A, Aittomäki K, Romundstad LB, Bergh C
Hum Reprod Update 2016 Mar-Apr;22(2):260-76. Epub 2015 Oct 9 doi: 10.1093/humupd/dmv046. PMID: 26454266
Education in children's sleep hygiene: which approaches are effective? A systematic review.
Halal CS, Nunes ML
J Pediatr (Rio J) 2014 Sep-Oct;90(5):449-56. Epub 2014 Jun 25 doi: 10.1016/j.jped.2014.05.001. PMID: 24973469

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