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Alcoholic liver diseases

MedGen UID:
9793
•Concept ID:
C0023896
•
Disease or Syndrome
Synonyms: Alcoholic Liver Disease; Alcoholic Liver Diseases; Liver Disease, Alcoholic; Liver Diseases, Alcoholic
SNOMED CT: ALD - Alcoholic liver disease (41309000); Alcoholic liver disease (41309000)
 
Monarch Initiative: MONDO:0043693

Definition

A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis. [from NCI]

Professional guidelines

PubMed

Glutathione in the treatment of liver diseases: insights from clinical practice.
Sacco R, Eggenhoffner R, Giacomelli L
Minerva Gastroenterol Dietol 2016 Dec;62(4):316-324. Epub 2016 Sep 7 PMID: 27603810
Alcoholic liver disease: treatment.
Suk KT, Kim MY, Baik SK
World J Gastroenterol 2014 Sep 28;20(36):12934-44. doi: 10.3748/wjg.v20.i36.12934. PMID: 25278689Free PMC Article
Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.
Orman ES, Odena G, Bataller R
J Gastroenterol Hepatol 2013 Aug;28 Suppl 1(0 1):77-84. doi: 10.1111/jgh.12030. PMID: 23855300Free PMC Article

Recent clinical studies

Etiology

Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcohol, liver disease and the gut microbiota.
Bajaj JS
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):235-246. doi: 10.1038/s41575-018-0099-1. PMID: 30643227
ACG Clinical Guideline: Alcoholic Liver Disease.
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Pathogenesis of Alcoholic Liver Disease.
Dunn W, Shah VH
Clin Liver Dis 2016 Aug;20(3):445-56. Epub 2016 Mar 28 doi: 10.1016/j.cld.2016.02.004. PMID: 27373608Free PMC Article
Alcoholic disease: liver and beyond.
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Diagnosis

Pathophysiological Aspects of Alcohol Metabolism in the Liver.
Hyun J, Han J, Lee C, Yoon M, Jung Y
Int J Mol Sci 2021 May 27;22(11) doi: 10.3390/ijms22115717. PMID: 34071962Free PMC Article
Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
ACG Clinical Guideline: Alcoholic Liver Disease.
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Alcoholic disease: liver and beyond.
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Therapy

Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease.
Wu X, Fan X, Miyata T, Kim A, Cajigas-Du Ross CK, Ray S, Huang E, Taiwo M, Arya R, Wu J, Nagy LE
Annu Rev Pathol 2023 Jan 24;18:411-438. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-030435. PMID: 36270295Free PMC Article
Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcoholic liver disease: mechanisms of injury and targeted treatment.
Louvet A, Mathurin P
Nat Rev Gastroenterol Hepatol 2015 Apr;12(4):231-42. Epub 2015 Mar 17 doi: 10.1038/nrgastro.2015.35. PMID: 25782093
Alcoholic liver disease: pathogenesis and new therapeutic targets.
Gao B, Bataller R
Gastroenterology 2011 Nov;141(5):1572-85. Epub 2011 Sep 12 doi: 10.1053/j.gastro.2011.09.002. PMID: 21920463Free PMC Article

Prognosis

Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases.
Crabb DW, Im GY, Szabo G, Mellinger JL, Lucey MR
Hepatology 2020 Jan;71(1):306-333. doi: 10.1002/hep.30866. PMID: 31314133
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Liver transplantation and alcoholic liver disease: History, controversies, and considerations.
Marroni CA, Fleck AM Jr, Fernandes SA, Galant LH, Mucenic M, de Mattos Meine MH, Mariante-Neto G, Brandão ABM
World J Gastroenterol 2018 Jul 14;24(26):2785-2805. doi: 10.3748/wjg.v24.i26.2785. PMID: 30018475Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Gut-liver axis in alcoholic liver disease.
Szabo G
Gastroenterology 2015 Jan;148(1):30-6. Epub 2014 Nov 11 doi: 10.1053/j.gastro.2014.10.042. PMID: 25447847Free PMC Article

Clinical prediction guides

ACG Clinical Guideline: Alcohol-Associated Liver Disease.
Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, Shah VH
Am J Gastroenterol 2024 Jan 1;119(1):30-54. Epub 2023 Sep 1 doi: 10.14309/ajg.0000000000002572. PMID: 38174913Free PMC Article
Alcohol-related hepatitis: A review article.
Chaudhry H, Sohal A, Iqbal H, Roytman M
World J Gastroenterol 2023 May 7;29(17):2551-2570. doi: 10.3748/wjg.v29.i17.2551. PMID: 37213401Free PMC Article
Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article

Recent systematic reviews

Prevalence of alcohol-associated liver disease: a systematic review and meta-analysis.
Amonker S, Houshmand A, Hinkson A, Rowe I, Parker R
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 26 doi: 10.1097/HC9.0000000000000133. PMID: 37102767Free PMC Article
Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis.
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD.
Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM
Hepatology 2020 Nov;72(5):1605-1616. Epub 2020 Oct 27 doi: 10.1002/hep.31173. PMID: 32043613
WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases.
Rambaldi A, Gluud C
Cochrane Database Syst Rev 2015 Nov 11;2015(11):CD002235. doi: 10.1002/14651858.CD002235.pub3. PMID: 26560497Free PMC Article

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