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Mediastinitis

MedGen UID:
9921
•Concept ID:
C0025064
•
Disease or Syndrome
Synonyms: Inflammation, Mediastinum; Inflammations, Mediastinum; Mediastinitides; Mediastinum Inflammation; Mediastinum Inflammations
SNOMED CT: Inflammatory disorder of mediastinum (373409004); Mediastinitis (373409004)
 
Monarch Initiative: MONDO:0004492

Definition

An inflammatory process affecting the mediastinum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinitis

Professional guidelines

PubMed

Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week.
Simard T, Sarma D, Miranda WR, Jain CC, Anderson JH, Collins JD, El Sabbagh A, Jhand A, Peikert T, Reeder GS, Munger TM, Packer DL, Holmes DR
J Am Coll Cardiol 2023 Jun 20;81(24):2361-2373. doi: 10.1016/j.jacc.2023.04.016. PMID: 37316116
Deep Sternal Wound Infection: Diagnosis, Treatment and Prevention.
Phoon PHY, Hwang NC
J Cardiothorac Vasc Anesth 2020 Jun;34(6):1602-1613. Epub 2019 Sep 18 doi: 10.1053/j.jvca.2019.09.019. PMID: 31623967
Treatment of histoplasmosis.
Mocherla S, Wheat LJ
Semin Respir Infect 2001 Jun;16(2):141-8. doi: 10.1053/srin.2001.24244. PMID: 11521246

Recent clinical studies

Etiology

Mediastinitis in the intensive care unit patient: a narrative review.
Pastene B, Cassir N, Tankel J, Einav S, Fournier PE, Thomas P, Leone M
Clin Microbiol Infect 2020 Jan;26(1):26-34. Epub 2019 Jul 12 doi: 10.1016/j.cmi.2019.07.005. PMID: 31306791
Catheter based treatments for fibrosing mediastinitis.
Fender EA, Widmer RJ, Knavel Koepsel EM, Welby JP, Kern R, Peikert T, Bjarnason H, Holmes DR Jr
Catheter Cardiovasc Interv 2019 Nov 15;94(6):878-885. Epub 2019 Feb 21 doi: 10.1002/ccd.28152. PMID: 30790443
Sternal reconstruction after post-sternotomy mediastinitis.
Kaul P
J Cardiothorac Surg 2017 Nov 2;12(1):94. doi: 10.1186/s13019-017-0656-7. PMID: 29096673Free PMC Article
Postoperative sterno-mediastinitis.
Robicsek F
Am Surg 2000 Feb;66(2):184-92. PMID: 10695750
Sternal wound infections.
Vaska PL
AACN Clin Issues Crit Care Nurs 1993 Aug;4(3):475-83. PMID: 8136226

Diagnosis

Acute mediastinitis, mediastinal granuloma, and chronic fibrosing mediastinitis: A review.
Lin J, Jimenez CA
Semin Diagn Pathol 2022 Mar;39(2):113-119. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.008. PMID: 34176697
Sternal reconstruction after post-sternotomy mediastinitis.
Kaul P
J Cardiothorac Surg 2017 Nov 2;12(1):94. doi: 10.1186/s13019-017-0656-7. PMID: 29096673Free PMC Article
Infections of the mediastinum.
Athanassiadi KA
Thorac Surg Clin 2009 Feb;19(1):37-45, vi. doi: 10.1016/j.thorsurg.2008.09.012. PMID: 19288819
Fibrosing mediastinitis.
Rossi SE, McAdams HP, Rosado-de-Christenson ML, Franks TJ, Galvin JR
Radiographics 2001 May-Jun;21(3):737-57. doi: 10.1148/radiographics.21.3.g01ma17737. PMID: 11353121
Postoperative sterno-mediastinitis.
Robicsek F
Am Surg 2000 Feb;66(2):184-92. PMID: 10695750

Therapy

Gram-negative bacteria as a cause of mediastinitis after cardiac surgery.
Peghin M, Pompei E, Vendramin I, Tascini C
Curr Opin Infect Dis 2021 Dec 1;34(6):710-717. doi: 10.1097/QCO.0000000000000785. PMID: 34654045
Mediastinitis in the intensive care unit patient: a narrative review.
Pastene B, Cassir N, Tankel J, Einav S, Fournier PE, Thomas P, Leone M
Clin Microbiol Infect 2020 Jan;26(1):26-34. Epub 2019 Jul 12 doi: 10.1016/j.cmi.2019.07.005. PMID: 31306791
Sternal reconstruction after post-sternotomy mediastinitis.
Kaul P
J Cardiothorac Surg 2017 Nov 2;12(1):94. doi: 10.1186/s13019-017-0656-7. PMID: 29096673Free PMC Article
Infections of the mediastinum.
Athanassiadi KA
Thorac Surg Clin 2009 Feb;19(1):37-45, vi. doi: 10.1016/j.thorsurg.2008.09.012. PMID: 19288819
Syphilitic mediastinitis.
LEATHER HM
Lancet 1953 Jul 18;265(6777):116-8. doi: 10.1016/s0140-6736(53)90056-7. PMID: 13070553

Prognosis

Surgical versus nonsurgical interventions for flail chest.
Cataneo AJ, Cataneo DC, de Oliveira FH, Arruda KA, El Dib R, de Oliveira Carvalho PE
Cochrane Database Syst Rev 2015 Jul 29;2015(7):CD009919. doi: 10.1002/14651858.CD009919.pub2. PMID: 26222250Free PMC Article
Invited commentary.
Hofstetter W
Ann Thorac Surg 2009 Sep;88(3):973. doi: 10.1016/j.athoracsur.2009.06.016. PMID: 19699930
Transhiatal esophagectomy.
Lin J, Iannettoni MD
Surg Clin North Am 2005 Jun;85(3):593-610. doi: 10.1016/j.suc.2005.01.009. PMID: 15927654
Fatal descending necrotising mediastinitis.
Bulut M, Balci V, Akköse S, Armağan E
Emerg Med J 2004 Jan;21(1):122-3. doi: 10.1136/emj.2003.002865. PMID: 14734401Free PMC Article
Thoracic infection after trauma.
Richardson JD, Carrillo E
Chest Surg Clin N Am 1997 May;7(2):401-27. PMID: 9156300

Clinical prediction guides

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome.
Hariri G, Genoud M, Bruckert V, Chosidow S, Guérot E, Kimmoun A, Nesseler N, Besnier E, Daviaud F, Lagier D, Imbault J, Grimaldi D, Bouglé A, Mongardon N
Crit Care 2023 Jan 6;27(1):6. doi: 10.1186/s13054-022-04277-6. PMID: 36609390Free PMC Article
Clamshell in a Heartbeat.
Vreeswijk SJM, Mommers LPW, Bergmans DCJJ, van Wageningen B
Air Med J 2020 Nov-Dec;39(6):509-511. Epub 2020 Aug 18 doi: 10.1016/j.amj.2020.08.001. PMID: 33228905
Minimally invasive Ozaki technique.
Rosseĭkin EV, Kobzev EE, Bazylev VV
Angiol Sosud Khir 2019;25(3):142-155. doi: 10.33529/ANGI02019319. PMID: 31503259
Mediastinitis following pediatric cardiac surgery.
Mangukia CV, Agarwal S, Satyarthy S, Datt V, Satsangi D
J Card Surg 2014 Jan;29(1):74-82. Epub 2013 Nov 25 doi: 10.1111/jocs.12243. PMID: 24267786
Descending mediastinitis.
Vural FS, Girdwood RW, Patel AR, Zigiriadis E
Asian Cardiovasc Thorac Ann 2012 Jun;20(3):304-7. doi: 10.1177/0218492311434088. PMID: 22718719

Recent systematic reviews

Pulmonary Vein Stenosis-Balloon Angioplasty Versus Stenting: A Systematic Review and Meta-Analysis.
Almakadma AH, Sarma D, Hassett L, Miranda W, Alkhouli M, Reeder GS, Munger TM, Packer DL, Simard T, Holmes DR Jr
JACC Clin Electrophysiol 2022 Oct;8(10):1323-1333. Epub 2022 Sep 16 doi: 10.1016/j.jacep.2022.08.008. PMID: 36117046
Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description.
Prado-Calleros HM, Jiménez-Fuentes E, Jiménez-Escobar I
Head Neck 2016 Apr;38 Suppl 1:E2275-83. Epub 2016 Feb 1 doi: 10.1002/hed.24183. PMID: 26829352
Surgical versus nonsurgical interventions for flail chest.
Cataneo AJ, Cataneo DC, de Oliveira FH, Arruda KA, El Dib R, de Oliveira Carvalho PE
Cochrane Database Syst Rev 2015 Jul 29;2015(7):CD009919. doi: 10.1002/14651858.CD009919.pub2. PMID: 26222250Free PMC Article
Systematic review on treatment of Zenker's diverticulum.
Verdonck J, Morton RP
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3095-107. Epub 2014 Sep 7 doi: 10.1007/s00405-014-3267-0. PMID: 25194579
Mediastinitis and blood transfusion in cardiac surgery: a systematic review.
Ang LB, Veloria EN, Evanina EY, Smaldone A
Heart Lung 2012 May;41(3):255-63. Epub 2011 Oct 1 doi: 10.1016/j.hrtlng.2011.07.012. PMID: 21963297

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