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Thiourea tasting(THIOT)

MedGen UID:
358312
•Concept ID:
C1868397
•
Finding
Synonym: THIOT
 
Gene (location): TAS2R38 (7q34)
 
OMIM®: 171200

Professional guidelines

PubMed

Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype.
Nolden AA, McGeary JE, Hayes JE
Chem Senses 2020 May 29;45(5):383-390. doi: 10.1093/chemse/bjaa028. PMID: 32382729Free PMC Article
Multiplex minisequencing screening for PTC genotype associated with bitter taste perception.
Sagong B, Bae JW, Rhyu MR, Kim UK, Ye MK
Mol Biol Rep 2014 Mar;41(3):1563-7. Epub 2014 Jan 12 doi: 10.1007/s11033-013-3002-8. PMID: 24413990
TAS2R38 genotypes and phenylthiocarbamide bitter taste perception in a population of young adults.
Khataan NH, Stewart L, Brenner DM, Cornelis MC, El-Sohemy A
J Nutrigenet Nutrigenomics 2009;2(4-5):251-6. Epub 2010 May 19 doi: 10.1159/000297217. PMID: 20484932

Recent clinical studies

Etiology

Genetic variation in taste perception: does it have a role in healthy eating?
Feeney E, O'Brien S, Scannell A, Markey A, Gibney ER
Proc Nutr Soc 2011 Feb;70(1):135-43. Epub 2010 Nov 22 doi: 10.1017/S0029665110003976. PMID: 21092367
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.
Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D
Science 2003 Feb 21;299(5610):1221-5. doi: 10.1126/science.1080190. PMID: 12595690
The influence of genetic taste markers on food acceptance.
Drewnowski A, Rock CL
Am J Clin Nutr 1995 Sep;62(3):506-11. doi: 10.1093/ajcn/62.3.506. PMID: 7661111
Blood groups and diseases.
Mourant AE
Haematologia (Budap) 1974;8(1-4):183-94. PMID: 4618230
Recent progress in pharmacogenetics.
Vesell ES
Adv Pharmacol Chemother 1969;7:1-52. PMID: 4195046

Diagnosis

Variations in the TAS2R38 gene among college students in Hubei.
Wang X, Wang L, Xia M, Teng F, Chen X, Huang R, Zhou J, Xiao J, Zhai L
Hereditas 2022 Dec 19;159(1):46. doi: 10.1186/s41065-022-00260-x. PMID: 36529808Free PMC Article
Validation of the Waterless Empirical Taste Test (WETT(®)).
Doty RL, Wylie C, Potter M
Behav Res Methods 2021 Apr;53(2):864-873. doi: 10.3758/s13428-020-01463-8. PMID: 32885386
Human taste genetics.
Drayna D
Annu Rev Genomics Hum Genet 2005;6:217-35. doi: 10.1146/annurev.genom.6.080604.162340. PMID: 16124860
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.
Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D
Science 2003 Feb 21;299(5610):1221-5. doi: 10.1126/science.1080190. PMID: 12595690
The influence of genetic taste markers on food acceptance.
Drewnowski A, Rock CL
Am J Clin Nutr 1995 Sep;62(3):506-11. doi: 10.1093/ajcn/62.3.506. PMID: 7661111

Therapy

Medical histories.
Dance A
Nature 2016 Sep 8;537(7619):S52-3. doi: 10.1038/537S52a. PMID: 27602739
Variation in the Ability to Taste Bitter Thiourea Compounds: Implications for Food Acceptance, Dietary Intake, and Obesity Risk in Children.
Keller KL, Adise S
Annu Rev Nutr 2016 Jul 17;36:157-82. Epub 2016 Apr 6 doi: 10.1146/annurev-nutr-071715-050916. PMID: 27070900
Taste genetics and gastrointestinal symptoms experienced in chronic kidney disease.
Manley KJ
Eur J Clin Nutr 2015 Jul;69(7):781-5. Epub 2015 May 27 doi: 10.1038/ejcn.2015.80. PMID: 26014268
Polyphenols: factors influencing their sensory properties and their effects on food and beverage preferences.
Lesschaeve I, Noble AC
Am J Clin Nutr 2005 Jan;81(1 Suppl):330S-335S. doi: 10.1093/ajcn/81.1.330S. PMID: 15640499
Krukenberg's spindles.
Wilensky JT, Buerk KM, Podos SM
Am J Ophthalmol 1975 Feb;79(2):220-5. doi: 10.1016/0002-9394(75)90075-6. PMID: 46720

Prognosis

Using the Integrated Genome Viewer to reveal amplicon-derived polymorphism enriched at the phenylthiocarbamide locus in the teaching lab.
Brenner ED, Scheid PE, DeGrazia J, Geltzeiler AR, Katari MS
Biochem Mol Biol Educ 2021 May;49(3):361-371. Epub 2021 Jan 11 doi: 10.1002/bmb.21479. PMID: 33426769
Does phenotypic expression of bitter taste receptor T2R38 show association with COVID-19 severity?
Barham HP, Taha MA, Hall CA
Int Forum Allergy Rhinol 2020 Nov;10(11):1255-1257. Epub 2020 Sep 29 doi: 10.1002/alr.22692. PMID: 32856411Free PMC Article
TAS2R38 genotypes and phenylthiocarbamide bitter taste perception in a population of young adults.
Khataan NH, Stewart L, Brenner DM, Cornelis MC, El-Sohemy A
J Nutrigenet Nutrigenomics 2009;2(4-5):251-6. Epub 2010 May 19 doi: 10.1159/000297217. PMID: 20484932
Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection.
Tepper BJ, White EA, Koelliker Y, Lanzara C, d'Adamo P, Gasparini P
Ann N Y Acad Sci 2009 Jul;1170:126-39. doi: 10.1111/j.1749-6632.2009.03916.x. PMID: 19686122
Krukenberg's spindles.
Wilensky JT, Buerk KM, Podos SM
Am J Ophthalmol 1975 Feb;79(2):220-5. doi: 10.1016/0002-9394(75)90075-6. PMID: 46720

Clinical prediction guides

Using the Integrated Genome Viewer to reveal amplicon-derived polymorphism enriched at the phenylthiocarbamide locus in the teaching lab.
Brenner ED, Scheid PE, DeGrazia J, Geltzeiler AR, Katari MS
Biochem Mol Biol Educ 2021 May;49(3):361-371. Epub 2021 Jan 11 doi: 10.1002/bmb.21479. PMID: 33426769
Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis.
Rowan NR, Soler ZM, Othieno F, Storck KA, Smith TL, Schlosser RJ
Int Forum Allergy Rhinol 2018 Sep;8(9):1013-1020. Epub 2018 Jul 4 doi: 10.1002/alr.22138. PMID: 29972727Free PMC Article
3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).
Tan J, Abrol R, Trzaskowski B, Goddard WA 3rd
J Chem Inf Model 2012 Jul 23;52(7):1875-85. Epub 2012 Jul 13 doi: 10.1021/ci300133a. PMID: 22656649
Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection.
Tepper BJ, White EA, Koelliker Y, Lanzara C, d'Adamo P, Gasparini P
Ann N Y Acad Sci 2009 Jul;1170:126-39. doi: 10.1111/j.1749-6632.2009.03916.x. PMID: 19686122
Krukenberg's spindles.
Wilensky JT, Buerk KM, Podos SM
Am J Ophthalmol 1975 Feb;79(2):220-5. doi: 10.1016/0002-9394(75)90075-6. PMID: 46720

Recent systematic reviews

Gustatory dysfunction is related to Parkinson's disease: A systematic review and meta-analysis.
Kwak IY, Kim KS, Min HJ
Int Forum Allergy Rhinol 2023 Oct;13(10):1949-1957. Epub 2023 Mar 30 doi: 10.1002/alr.23158. PMID: 36934313

Supplemental Content

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    Clinical resources

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    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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