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Candidiasis, familial, 6(CANDF6)

MedGen UID:
462755
•Concept ID:
C3151405
•
Disease or Syndrome
Synonyms: CANDF6; Candidiasis, familial, 6, autosomal dominant
 
Gene (location): IL17F (6p12.2)
 
Monarch Initiative: MONDO:0013503
OMIM®: 613956

Definition

Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene. [from MONDO]

Clinical features

From HPO
Chronic mucocutaneous candidiasis
MedGen UID:
2426
•Concept ID:
C0006845
•
Disease or Syndrome
Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Inflammatory invasion on human vaginal mucosa correlated with combined drug treatment and recurrence in recurrent vulvovaginal candidiasis.
He X, Tang Q, Zhan F, Mao Y, Ye F, Weng Z, Jiang X, Swidsinski A
J Obstet Gynaecol Res 2023 May;49(5):1443-1451. Epub 2023 Feb 11 doi: 10.1111/jog.15577. PMID: 36772906
Survey of healthcare providers' testing practices for vulvovaginal candidiasis and treatment outcomes-United States, 2021.
Benedict K, Moret R, Molinari NAM, Jackson BR
PLoS One 2022;17(12):e0278630. Epub 2022 Dec 30 doi: 10.1371/journal.pone.0278630. PMID: 36584109Free PMC Article
A Risk Assessment Tool for Identifying Pregnant and Postpartum Women Who May Benefit From Preexposure Prophylaxis.
Pintye J, Drake AL, Kinuthia J, Unger JA, Matemo D, Heffron RA, Barnabas RV, Kohler P, McClelland RS, John-Stewart G
Clin Infect Dis 2017 Mar 15;64(6):751-758. doi: 10.1093/cid/ciw850. PMID: 28034882Free PMC Article

Recent clinical studies

Etiology

Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Recurrent vaginal candidiasis.
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
New and old immunodeficiencies.
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Diagnosis

Correlation between postpartum pelvic floor dysfunction and vaginal microecological imbalance in late pregnancy.
Cheng C, Guo B, Li R, Wu W, Mi C, Li X
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Nov 28;47(11):1608-1614. doi: 10.11817/j.issn.1672-7347.2022.220100. PMID: 36481640Free PMC Article
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Resistant pathogens, fungi, and viruses.
Guidry CA, Mansfield SA, Sawyer RG, Cook CH
Surg Clin North Am 2014 Dec;94(6):1195-218. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.010. PMID: 25440119Free PMC Article
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Therapy

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Recurrent vulvovaginal candidiasis.
Belayneh M, Sehn E, Korownyk C
Can Fam Physician 2017 Jun;63(6):455. PMID: 28615397Free PMC Article
Resistant pathogens, fungi, and viruses.
Guidry CA, Mansfield SA, Sawyer RG, Cook CH
Surg Clin North Am 2014 Dec;94(6):1195-218. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.010. PMID: 25440119Free PMC Article
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Prognosis

Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Oral Candida Predicts Streptococcus mutans Emergence in Underserved US Infants.
Alkhars N, Zeng Y, Alomeir N, Al Jallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J
J Dent Res 2022 Jan;101(1):54-62. Epub 2021 May 21 doi: 10.1177/00220345211012385. PMID: 34018817Free PMC Article
Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry.
Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2018 May-Jun;6(3):996-1001. Epub 2017 Sep 19 doi: 10.1016/j.jaip.2017.06.041. PMID: 28939137Free PMC Article
Recurrent vaginal candidiasis.
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267

Clinical prediction guides

Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Oral Candida Predicts Streptococcus mutans Emergence in Underserved US Infants.
Alkhars N, Zeng Y, Alomeir N, Al Jallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J
J Dent Res 2022 Jan;101(1):54-62. Epub 2021 May 21 doi: 10.1177/00220345211012385. PMID: 34018817Free PMC Article
Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern.
Bitew A, Abebaw Y
BMC Womens Health 2018 Jun 15;18(1):94. doi: 10.1186/s12905-018-0607-z. PMID: 29902998Free PMC Article
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
New and old immunodeficiencies.
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870

Recent systematic reviews

Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Kahwati LC, Clark R, Berkman N, Urrutia R, Patel SV, Zeng J, Viswanathan M
JAMA 2020 Apr 7;323(13):1293-1309. doi: 10.1001/jama.2020.0233. PMID: 32259235

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