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Rex2 reduced expression 2 [ Mus musculus (house mouse) ]

Gene ID: 100043034, updated on 8-Feb-2024

Summary

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Official Symbol
Rex2provided by MGI
Official Full Name
reduced expression 2provided by MGI
Primary source
MGI:MGI:1328322
See related
Ensembl:ENSMUSG00000067919 AllianceGenome:MGI:1328322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm13138
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in blastocyst; early embryo; and limb. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Rex2 in Genome Data Viewer
Location:
4 E1; 4 78.42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (147058071..147145256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (146973610..147060799)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene Neighboring gene predicted gene 13149 Neighboring gene STARR-seq mESC enhancer starr_12046 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146352913-146353213 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146354424-146354725 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146356350-146356650 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146358253-146358554 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146359517-146359818 Neighboring gene predicted gene, 46895 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146416384-146416684 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene RIKEN cDNA 4933438K21 gene Neighboring gene predicted gene 13160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Faria TN, et al. Mol Cell Endocrinol, 1998 Aug 25. PMID 9806360
  2. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC76572

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reduced expression 2
Names
novel KRAB box domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177767.1 → NP_001171238.1  reduced expression 2

    Status: VALIDATED

    Source sequence(s)
    AL954334
    Consensus CDS
    CCDS51374.1
    UniProtKB/TrEMBL
    A2AWF2
    Related
    ENSMUSP00000075179.6, ENSMUST00000075775.6
    Conserved Domains (3) summary
    COG5048
    Location:277 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 67
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    147058071..147145256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253012.2 → XP_030108872.1  reduced expression 2 isoform X1

    UniProtKB/TrEMBL
    A2AWF2
    Conserved Domains (3) summary
    COG5048
    Location:277 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 67
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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