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R3hdml R3H domain containing-like [ Mus musculus (house mouse) ]

Gene ID: 100043899, updated on 12-May-2024

Summary

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Official Symbol
R3hdmlprovided by MGI
Official Full Name
R3H domain containing-likeprovided by MGI
Primary source
MGI:MGI:3650937
See related
Ensembl:ENSMUSG00000078949 AllianceGenome:MGI:3650937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable peptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 1.6), kidney adult (RPKM 1.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See R3hdml in Genome Data Viewer
Location:
2 H3; 2 84.31 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163333364..163344532)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163491439..163502621)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ganglioside-induced differentiation-associated protein 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_06310 Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4516 Neighboring gene fat storage-inducing transmembrane protein 2 Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06311 Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881 Neighboring gene Crx opposite strand transcript 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. R3hdml regulates satellite cell proliferation and differentiation. Sakamoto K, et al. EMBO Rep, 2019 Nov 5. PMID 31524320, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidase inhibitor R3HDML
Names
cysteine-rich secretory protein R3HDML
novel SCP-like extracellular protein domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099331.2 → NP_001092801.1  peptidase inhibitor R3HDML precursor

    See identical proteins and their annotated locations for NP_001092801.1

    Status: VALIDATED

    Source sequence(s)
    AL591488
    Consensus CDS
    CCDS38316.1
    UniProtKB/Swiss-Prot
    A2A5I3
    Related
    ENSMUSP00000105043.3, ENSMUST00000109416.3
    Conserved Domains (1) summary
    cd18815
    Location:63 → 208
    CAP_R3HDML; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163333364..163344532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498522.5 → XP_006498585.1  peptidase inhibitor R3HDML isoform X1

    See identical proteins and their annotated locations for XP_006498585.1

    UniProtKB/Swiss-Prot
    A2A5I3
    Conserved Domains (1) summary
    cd18815
    Location:63 → 208
    CAP_R3HDML; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML

  2. XM_006498524.4 → XP_006498587.1  peptidase inhibitor R3HDML isoform X2

    Conserved Domains (1) summary
    cl00133
    Location:1 → 95
    CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A5I3.1 GenPept UniProtKB/Swiss-Prot:A2A5I3

Gene LinkOut

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